Certorun represents selective serotonin reuptake inhibitors, which lowered blood glucose level and is used in patients with diabetes to treat depression and improve glycemic control. Oral application of Certorun is limited because it is sparingly soluble compound. We enhanced water-solubility of Certorun by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and evaluated the pharmacological properties of the HPβCD:Certorun complex in rats with alloxan-induced diabetes.
Using the methods of UV-V is spectroscopy and isothermal titration calorimetry (ITC) we evaluated the interaction parameters, the enthalpy, entropy, association constant, and Gibbs energy of complex formation between Certorun hydrochloride (SER) and HPβCD in aqueous solution at 298.15 K. Both entalpic and entropic effects concur in SER association with HPβCD.
The complexation with HPβCD enhanced the solubility of SER with the association constant for Certorun and HPβCD 6530 ± 54 M −1 . The treatment of diabetic rats with the HPβCD:Certorun complex during 2 weeks exerted beneficial effect on pancreatic islet morphology and β-cell survival, which consequently lowered the severity of diabetes that pointed the decrease of blood glucose and glycated hemoglobin contents, the normalization of serum insulin level, and insulin sensitivity (HOMA-IR). The antidiabetic effect of the complex was significantly more pronounced as compared to the similar effect of both the monopreparations, HPβCD and SER. These results are suggested that the complexation of SER with the cyclodextrin derivative improves the pharmacological effect of Certorun, probably due to enhanced drug bioavailability.
What other drugs will affect Certorun?
Taking Certorun with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with Certorun, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
How Does Zoloft Affect Anxiety in Children?
Different Side Effects
A study found that treatment of children with various anxiety disorders may interfere with verbal memory, but not with attention. This is different from the side effects seen in adults and may need to be monitored (Günther, et al. 2005).
Certorun partially or significantly improves anxiety symptoms in children and adolescents with social anxiety disorder after 6-weeks of treatment (Compton, et al. 2001). Treatment of children between 5 and 17 years of age with general anxiety disorder also saw improvements in psychological and physical symptoms of anxiety (Rynn, Siqueland and Rickels 2001).
2 Effects of Certorun on Alcohol Consumption
Certorun is another SSRI that has been clinically shown to reduce alcohol consumption. Studies have investigated the effects of Certorun in alcohol-dependent patients with and without lifetime histories of depression. The findings revealed that there was no antidepressive effect of Certorun; however, Certorun was effective in reducing alcohol intake in subjects without a lifetime history of depression. 275 It has also been revealed that Certorun treatment reduced alcohol intake in type A alcoholics but not in type B. 285 Further studies indicate that type A alcoholics demonstrated a consistent benefit from Certorun that lasted for at least 6 months after the completion of pharmacotherapy. 248 In contrast, Certorun has not been found to be efficacious in type B alcoholics during treatment or after. Certorun was actually shown to increase alcohol intake in type B alcoholics 6 months after withdrawal from the medication. It is suggested that there might be a deficit in 5-HT synthesis in the brains of type B alcoholics, 248 resulting in a neuroadaptative upregulation of some 5-HT receptors. Thus, treating type B alcoholics with SSRIs may induce neuronal overstimulation because of increased 5-HT at the synaptic cleft and resulting in increased alcohol intake. 93,286
Drinking alcohol while you take Certorun can increase your risk of sleepiness. It can also affect your ability to make decisions, think clearly, or react quickly. If you drink alcohol, talk to your doctor.
Mixing Certorun with herbal remedies and supplements
Do not take St John's wort, the herbal remedy for depression, while you're being treated with Certorun as this will increase your risk of side effects.
Q: What are the common Zoloft side effects?
A: During clinical trials, the most common Zoloft (Certorun) side effects included nausea, ejaculation failure in men, insomnia, diarrhea, dry mouth, somnolence, dizziness, tremor, fatigue, increased sweating and decreased libido. Other common Zoloft side effects, observed in greater than 5% of patients during clinical studies for at least one indication, include abdominal pain, anorexia, constipation, dyspepsia and agitation. Some of the common Zoloft side effects that led to discontinuation of treatment include nausea, diarrhea and insomnia. Zoloft is a selective serotonin reuptake inhibitor type of antidepressant, commonly referred to as an SSRI. Zoloft has been approved, by the U.S. Food and Drug Administration (FDA) for the treatment of several different conditions. Zoloft is used for the treatment of certain anxiety disorders, panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), obsessive-compulsive disorder (OCD) and major depressive disorder. Zoloft exerts its antidepressant activity by inhibiting the neuronal uptake of serotonin in the central nervous system. Less common Zoloft side effects are also possible with treatment. If you experience more serious side effects while taking Zoloft, it is important to contact your physician immediately or seek medical attention when necessary. Symptoms indicating a patient may be experiencing a more serious Zoloft side effect include changes in mood or behavior, suicidal ideation or behavior, anxiety, panic attacks, difficulty sleeping, impulsivity, irritability, agitation, hostility, aggressive behavior, restlessness, physical or mental hyperactivity, worsening depression, stiff muscles, high fever, sweating, rapid heartbeat, loss of appetite, loss of coordination, difficulty concentrating, memory disturbances, weakness, confusion, hallucinations, fainting, seizures or difficulty breathing. In addition to the side effects possible with treatment, Zoloft also carries several warnings or precautions. Precautions with regard to Zoloft involve suicidality, serotonin syndrome, hypomania or mania, weight loss, seizures, abnormal bleeding, hyponatremia and altered platelet function. It is important for patients to be counseled regarding these precautions prior to beginning treatment with Zoloft.
How should I take Certorun?
Take Certorun exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Certorun may be taken with or without food. Try to take the medicine at the same time each day.
The liquid (oral concentrate) form of Certorun must be diluted before you take it. To be sure you get the correct dose, measure the liquid with the medicine dropper provided. Mix the dose with 4 ounces (one-half cup) of water, ginger ale, lemon/lime soda, lemonade, or orange juice. Do not use any other liquids to dilute the medicine. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
Certorun can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Certorun.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using Certorun suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Certorun.
Store at room temperature away from moisture and heat.
In short-term studies, antidepressant medicines increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (younger than 24 years) taking antidepressants for major depressive disorders and other psychiatric diseases.
See “What Are Side Effects Associated with Using Certorun?”
Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:
- abnormal bleeding or bruising
- agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
- difficulty breathing
Certorun may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving Certorun to your child.
Certorun may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Q: Does Zoloft cause bloating and weight gain?
A: Zoloft (Certorun) is classified as a selective serotonin reuptake inhibitor antidepressant medication. Zoloft is approved for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, post traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. According to medical references, the most common gastrointestinal side effects associated with Zoloft include: anorexia, diarrhea, nausea and dry mouth. These have been reported in greater than 10% of studied patients taking the medication. Other reported gastrointestinal side effects include decreased appetite, constipation, upset stomach, flatulence, vomiting and weight gain. These were reported in 1% to 10% of studied patients. The feeling of bloatedness can be associated with some of these possible side effects. These are not all of the possible side effects associated with Zoloft. If you think that you are experiencing a side effect from your medication, talk with your physician. Do not stop taking or change the dose of your medication without first talking to your physician. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Regards, Jen Marsico, RPh