Calixta tablets


  • Active Ingredient: Mirtazapine
  • 30 mg, 15 mg
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What is Calixta?

The active ingredient of Calixta brand is mirtazapine. Mirtazapine is an antidepressant. Mirtazapine affects chemicals in the brain that may be unbalanced in people with depression.

Used for

Calixta is used to treat diseases such as: Anxiety, Depression, Hot Flashes, Insomnia, Major Depressive Disorder, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder.

Side Effect

Possible side effects of Calixta include: Constipation; increased need to urinate; convulsions (seizures); Decreased or increased movement; nausea; menstrual pain; drowsiness.

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Concomitant administration of diazepam (15 mg) had a minimal effect on plasma levels of Calixta (15 mg) in 12 healthy subjects. However, the impairment of motor skills produced by REMERON has been shown to be additive with those caused by diazepam. Accordingly, patients should be advised to avoid diazepam and other similar drugs while taking REMERON.

Calixta interacts with several different drugs. Drug interactions can prevent the medication from working in the usual way, and they can lead to dangerous side effects.

To help avoid these, a person should discuss all their medications, including both over the counter and prescription drugs, with their healthcare provider before starting Calixta. They should also make them aware of any vitamins or other supplements that they are taking.

Certain medications increase the risk of a person developing serotonin syndrome. A person should not take any of the following when taking Calixta:

  • monoamine oxidase inhibitors (MAOIs)
  • intravenous methylene blue
  • an antibiotic called linezolid (Zyvox)

Other medications can cause or increase the risk of side effects, including the following:

  • lithium, triptan, and serotonergic medications may increase a person's risk of developing serotonin syndrome
  • benzodiazepines may promote drowsiness
  • warfarin may increase the risk of heavy bleeding

Calixta Side Effects

While Calixta is seen as more tolerable than SSRIs, common side effects from Calixta include drowsiness, dizziness, strange dreams, vision changes, dry mouth, constipation, increased appetite and/or weight gain .

If any of these side effects persist or worsen, tell your doctor or pharmacist.

One study observed a significant increase in weight gain in the first week of therapy .

Calixta has shown in rare cases to cause liver damage . If you experience serious side effects while taking this medication, seek medical help urgently

Drugs you shouldn’t take

Taking certain drugs with Calixta may cause serious side effects. You shouldn’t take these medications while taking Calixta.These drugs include:

  • Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, and tranylcypromine. Taking these drugs with Calixta can increase your risk of serotonin syndrome. If you need to take an MAOI, you must wait 14 days after you stop taking Calixta before you start taking the MAOI. The same rule applies if you switch from taking an MAOI to Calixta. If you’re switching from one of these drugs to the other, seek medical help right away if you have symptoms of serotonin syndrome.
  • Linezolid and intravenous methylene blue. Taking these drugs with Calixta can increase your risk of serotonin syndrome.

Associated With Discontinuation Of Treatment

Approximately 16% of the 453 patients who received REMERON (Calixta) Tablets in US 6-week controlled clinical trials discontinued treatment due to an adverse experience, compared to 7% of the 361 placebo-treated patients in those studies. The most common events ( ≥ 1%) associated with discontinuation and considered to be drug related (i.e., those events associated with dropout at a rate at least twice that of placebo) are included in Table 2.

Table 2: Common Adverse Events Associated With Discontinuation of Treatment in 6-Week US REMERON Trials

FDA warning: Suic >
  • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Calixta may cause an increase in suicidal thoughts or actions. This risk is higher in children, teenagers, and young adults. It’s also higher within the first few months of treatment and during dosage changes. You and your family members, caregivers, and doctor should watch for any new or sudden changes in your mood, behaviors, thoughts, or feelings. Call your doctor right away if you notice any of these changes.

What if I forget to take it?

If you take Calixta once a day and miss a dose, skip it and take the next dose at the normal time. Do not take a double dose to make up for a forgotten dose.

If you take Calixta twice a day and forget:

your morning dose – take it together with your evening dose

your evening dose – do not take it with the next morning dose. Instead skip the missed dose, and then continue the next day with your normal morning and evening doses

both doses – skip the missed doses. Continue the next day with your normal morning and evening doses. Do not take an extra dose to make up for a missed dose

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

Rated Calixta (Remeron) for Depression Report

Terrible experience with this drug . Had ocd and anxiety for 30 horrendous years . Have tried most of the drugs I can think of, during a particular difficult period my consultant had the brilliant idea! Put me on something new . Please please be careful of this as we all know our GPs cannot supervise 24/7. I became agitated agrresive my mood plummeted my depression increased. My doctor doubled the dose and gave me diazepam. Taking this medication has set me back years in my humble opinion with regard to my ocd it was as bad as when I first started. I have made the decision to stop taking this medication from immediate effect it was making me feel suicdal The only thing in its favour was that it made me sleep and god forgive if I missed one ! Please be careful with this drug it’s powerful and has cost me dearly ! Good luck to all of you and I hope you get better.


Before taking this medication, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history or family history of psychiatric disorders (e.g., bipolar/manic-depressive disorder), history or family history of suicide attempts, liver disease, kidney disease, seizures, high blood cholesterol or triglyceride levels, heart disease (e.g., recent heart attack, angina), stroke, severe loss of body fluids (dehydration), low blood pressure, personal or family history of glaucoma (angle-closure type).

Calixta may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Calixta, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Calixta safely.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition where you must restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist regarding the safe use of this medicine.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and QT prolongation (see above).

This medication should be used only when clearly needed during pregnancy. If this medication is used during the last 3 months of pregnancy, infrequently your newborn may develop symptoms including feeding or breathing difficulties, seizures, muscle stiffness, jitteriness or constant crying. Report any such symptoms to your doctor promptly. However, since untreated mental/mood disorders (such as depression) can be a serious condition, do not stop taking this medication unless your doctor directs you to do so. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk. Consult your doctor before breast-feeding.

More common side effects

The more common side effects of Calixta can include:

  • sleepiness
  • increased appetite
  • weight gain
  • dry mouth
  • constipation
  • dizziness
  • strange dreams

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Drugs that reduce the amount of Calixta in your body

These drugs can reduce the levels of Calixta in your body. If you need to take these drugs with Calixta, your doctor may increase your Calixta dosage.

  • Phenytoin
  • Carbamazepine

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Discontinuation symptoms

A person should not stop taking Calixta suddenly. Abruptly stopping this medication can lead to the following symptoms:

  • dizziness
  • tingling or prickling sensations
  • anxiety
  • agitation
  • confusion
  • fatigue
  • nausea or vomiting
  • headaches

People who are stopping their use of the drug should work with their healthcare provider to come off it gradually.

Rated Calixta (Remeron) for Depression Report

after trying citalopram for a few unsuccessful weeks my doctor put me on to Calixta. in fairness, this drug did lift my mood, calmed some of my darker thoughts and in general i was less anxious and within 20 mins of taking this drug i would be in a deep sleep. however, (something my doctor never mentioned to me) was the side effect of weight gain. from what i can grasp of other reviews, the increased appetite and as a result weight gaining side effects of this drug are totally different for each person. from these reviews and other information i have read it seems to be people of a lower weight that are more effect by the weight gain side effect. i ate a lot of food before i started this drug despite only being 8 stone however over time i noticed i couldn’t stop eating.. carbs were my biggest killer, it seems crazy to say but it was like having an addiction to food. bread and butter, crisps, chips. anything and everything. i was blind to this as it helped my depresison and insomnia however 8 months in it started to hit me, i’d gained 3 stone and nearly all of it was on my belly. i cut myself off from the drug cold turkey because i honestly felt ready but i would advice anyone

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