Aserin capsules

Aserin

  • Active Ingredient: Sertraline
  • 100 mg, 50 mg, 25 mg
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What is Aserin?

The active ingredient of Aserin brand is sertraline. Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. Sertraline tablets, USP for oral administration are supplied as scored tablets containing Sertraline hydrochloride equivalent to 25 mg, 50 mg and 100 mg of Sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, opadry green (titanium dioxide, hypromellose 3cP, hypromellose 6cP, Macrogol/Peg 400, polysorbate 80, D&C Yellow #10 Aluminum Lake, and FD&C Blue # 2/Indigo Carmine Aluminum Lake for 25 mg tablet), opadry light blue (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, FD&C Blue #2/Indigo Carmine Aluminum Lake and polysorbate 80 for 50 mg tablet), opadry yellow (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, polysorbate 80, Iron Oxide Yellow, Iron oxide Red for 100 mg tablet) and sodium starch glycolate.

Used for

Aserin is used to treat diseases such as: Anxiety and Stress, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Dissociative Identity Disorder, Dysautonomia, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Panic Disorder, Persistent Depressive Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Social Anxiety Disorder, Somatoform Pain Disorder, Transverse Myelitis, Trichotillomania, Vulvodynia.

Side Effect

Possible side effects of Aserin include: difficulty with breathing; chest pain or discomfort; clay-colored stools; vomiting of blood; lack of energy; high fever.

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Storage And Handling

ZOLOFT 25 mg tablets: light green, film-coated, capsular-shaped tablets engraved on one side with “ZOLOFT” and on the other side scored and engraved with “25 mg”

NDC 0049-4960-30 Bottles of 30 NDC 0049-4960-50 Bottles of 50

ZOLOFT 50 mg tablets: light blue, film-coated, capsular-shaped tablets engraved on one side with “ZOLOFT” and on the other side scored and engraved with “50 mg”

NDC 0049-4900-30 Bottles of 30 NDC 0049-4900-66 Bottles of 100 NDC 0049-4900-73 Bottles of 500 NDC 0049-4900-94 Bottles of 5000 NDC 0049-4900-41 Unit Dose Packages of 100

ZOLOFT 100 mg tablets: light yellow, film-coated, capsular-shaped, tablets engraved on one side with “ZOLOFT” and on the other side scored and engraved with “100 mg”

NDC 0049-4910-30 Bottles of 30 NDC 0049-4910-66 Bottles of 100 NDC 0049-4910-73 Bottles of 500 NDC 0049-4910-94 Bottles of 5000 NDC 0049-4910-41 Unit Dose Packages of 100

ZOLOFT oral solution: clear, colorless solution with a menthol scent containing Aserin hydrochloride equivalent to 20 mg of Aserin per mL and 12% alcohol

NDC 0049-4940-23 Bottles containing 60 mL, each with an accompanying calibrated dropper that has 25 mg and 50 mg graduation marks.

What other drugs will affect Aserin?

Taking Aserin with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with Aserin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Alcohol interaction

Drinking alcohol while you take Aserin can increase your risk of sleepiness. It can also affect your ability to make decisions, think clearly, or react quickly. If you drink alcohol, talk to your doctor.

What is Aserin (Zoloft)?

Aserin is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Aserin affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms.

Aserin may also be used for purposes not listed in this medication guide.

RESULTS AND CONCLUSION

Following treatment with Aserin , mianserin, phenelzine or deprenyl there were some regionally specific alterations in the number of binding sites, but the effects were modest in size (10-20%) and no common effects were seen. Small increases in binding were seen in 4 brain regions for each of the MAO inhibitors (2 hippocampal areas - CA1 and dentate gyrus were affected by both drugs) whereas decreases were seen in 3 brain areas for the serotonin uptake inhibitor Aserin (CA1 region of hippocampus, lateral amygdaloid nucleus and parietal cortex) and in 1 area following the α 2 adrenergic antagonist mianserin (dentate gyrus). In contrast, following administration of the serotonin uptake inhibitor citalopram or the norepinephrine uptake inhibitor protriptyline no effect on binding was seen in any brain region examined. We conclude that repeated administration of antidepressant drugs does not produce consistent effects on serotonin uptake sites.

Contraindications

Do not use disulfiram concomitantly with oral solution due to alcohol in preparation

Concomitant pimozide: Risk of long QT syndrome

Coadministration with serotonergic drugs

  • Do not use MAOIs concomitantly or within 14 days before initiating Aserin or within 14 days after discontinuing Aserin
  • Reactions to concomitant administration with MAO inhibitors include tremor, myoclonus, diaphoresis, nausea, vomiting, flushing, dizziness, hyperthermia with features resembling neurolepticmalignantsyndrome, seizures, rigidity, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma
  • Starting Aserin in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome
  • If linezolid or IV methylene blue must be administered, discontinue SSRI immediately and monitor for CNStoxicity; may resume 24 hours after last linezolid or methylene blue dose, or after 2 weeks of monitoring (5 weeks for fluoxetine), whichever comes first

On this page

  1. About Aserin
  2. Key facts
  3. Who can and can't take Aserin
  4. How and when to take it
  5. Side effects
  6. How to cope with side effects
  7. Pregnancy and breastfeeding
  8. Cautions with other medicines
  9. Common questions

2 Effects of Aserin on Alcohol Consumption

Aserin is another SSRI that has been clinically shown to reduce alcohol consumption. Studies have investigated the effects of Aserin in alcohol-dependent patients with and without lifetime histories of depression. The findings revealed that there was no antidepressive effect of Aserin; however, Aserin was effective in reducing alcohol intake in subjects without a lifetime history of depression. 275 It has also been revealed that Aserin treatment reduced alcohol intake in type A alcoholics but not in type B. 285 Further studies indicate that type A alcoholics demonstrated a consistent benefit from Aserin that lasted for at least 6 months after the completion of pharmacotherapy. 248 In contrast, Aserin has not been found to be efficacious in type B alcoholics during treatment or after. Aserin was actually shown to increase alcohol intake in type B alcoholics 6 months after withdrawal from the medication. It is suggested that there might be a deficit in 5-HT synthesis in the brains of type B alcoholics, 248 resulting in a neuroadaptative upregulation of some 5-HT receptors. Thus, treating type B alcoholics with SSRIs may induce neuronal overstimulation because of increased 5-HT at the synaptic cleft and resulting in increased alcohol intake. 93,286

Other uses for this medicine

Aserin is also used sometimes to treat headaches and sexual problems. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Q: I've been prescribed Zoloft (generic version) for depression. I'm also 33 weeks pregnant. Is it safe for me to take this drug for the rest of my pregnancy?

A: Zoloft (Aserin) is a pregnancy category C medicine, meaning that the medication could potentially cause harm to your unborn child. This is especially true during the third trimester of pregnancy. A health care provider may still prescribe a pregnancy category C medicine to a pregnant woman if he or she believes that the benefits to the woman outweigh the possible risks to the unborn child. There have been reports of fetuses being exposed to Zoloft during the third trimester of pregnancy, developing complications that require hospitalization, respiratory support, and/or tube feeding. Also, babies exposed to Zoloft late during pregnancy are at increased risk for developing persistent pulmonary hypertension of the newborn (PPHN). PPHN is associated with significant complications and even death. Women who take SSRIs, including Zoloft, after week 20 of pregnancy have a sixfold increase of delivering a baby with PPHN. It's possible that your physician may recommend reducing your dosage, or weaning you off Zoloft during the third trimester of pregnancy. You really should have a discussion with the physician about taking this medication throughout the entire pregnancy. Lori Poulin, PharmD

What is the most important information I should know about Aserin (Zoloft)?

You should not use Aserin if you also take pimozide, or if you are being treated with methylene blue injection.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Anxiety medications can be life-changing for people with generalized anxiety, panic disorder and obsessive compulsive disorder. But they come with serious tradeoffs. Benzodiazepines are unquestionably effective for anxiety but have adverse neurological effects like memory impairment.

In the last two decades, SSRIs like Zoloft (Aserin) have been repurposes as treatments for anxiety. While hypnotics work immediately, one caveat of SSRIs is that they can take up to 6 weeks to work. Moreover, SSRIs don't work for every body and in some cases may exacerbate social anxiety. For example, Frick and colleagues argue that individuals with social phobia have too much serotonin, not too little.

Genetic differences may play a role in whether SSRIs are effective for anxiety. Polymorphisms affecting the serotonin transporter impact patients' ability to tolerate serotonergic agents.

Aserin

Aserin has a half-life of 26 hours. Based on about 110 mother– child pairs, the average relative dose for a fully breastfed child is almost 2% ( Merlob 2004 , Weissman 2004 , Hendrick 2001A ). In 1997, Stowe analyzed 148 milk samples from 12 mothers. The highest concentrations for Aserin were around 173μg/l; for desmethylAserin, which has a significantly lower psychopharmacological action, it was 294μg/l. Maternal dosages ranged from 25 to 200mg daily. There were traces of Aserin in the serum of some children, and in three of them a level of about 10μg/l desmethylAserin was measured ( Merlob 2004 , Weissman 2004 , Hendrick 2001A ). In other infants either no substance was found or the levels were near or below the level of quantifiability ( Wisner 2006 , Berle 2004 ). In only one breastfed baby were serum levels equal to 50% of the maternal values found ( Wisner 1998 ). The authors of the study could not understand this, and suggested direct administration of the medication to the baby as the cause. None of the babies was remarkable. Decreasing serum values of desmethylAserin with age were observed among 30 breastfed children ( Hendrick 2001A ). A maternal dosage of above 100mg/day was significantly correlated with the detection of Aserin in the infant's serum. Breastfed infants showed little or no change in platelet 5-hydroxytryptamine (5-HT) levels after exposure through breastfeeding. According to the authors of this study, the observations suggest that peripheral or central 5-HT transport in these infants is not affected by Aserin therapy of their mothers.

Aserin, paroxetin, citalopram, and fluvoxamin are the drugs of choice among SSRIs for breastfeeding mothers. In case of fluoxetin or escitalopram therapy, special attention should be paid to potential side effects in the breastfed child. In general, monotherapy should be the goal. If symptoms appear that are potentially associated with SSRI therapy, a pediatrician and a teratology information center should be contacted to decide individually upon measuring drug values in the infant's serum, supplementary formula feeding, weaning, and/or changing therapy. As with all psychoactive drugs, there is insufficient experience on the long-term effects on breastfed children as a result of ongoing therapy to their mothers.

7. Pregnancy and breastfeeding

It's important for you and your baby that you stay well during your pregnancy.

If you become pregnant while taking Aserin, speak to your doctor. Do not stop taking your medicine unless your doctor tells you to.

Aserin has been linked to a very small increased risk of problems for your unborn baby.

But if your depression isn't treated during pregnancy, this can also increase the chance of problems.

You may take Aserin during pregnancy if you need it to remain well. Your doctor can explain the risks and the benefits, and will help you decide which treatment is best for you and your baby.

For more information about how Aserin can affect you and your baby during pregnancy, read the leaflet about the best use of medicines in pregnancy (BUMPS).

6. How to cope with s >

What to do about:

  • feeling sick - try taking Aserin with or after food. It may also help if you avoid rich or spicy food.
  • headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking Aserin. Talk to your doctor if they last longer than a week or are severe.
  • being unable to sleep - take Aserin first thing in the morning
  • feeling sleepy - take Aserin in the evening and cut down the amount of alcohol you drink. Do not drive or use tools or machinery if you're feeling sleepy. If this doesn't help, talk to your doctor.
  • diarrhoea - drink plenty of water or other fluids to avoid dehydration. Signs of dehydration include peeing less than usual and having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • dry mouth - chew sugar-free gum or sugar-free sweets
  • dizziness - if Aserin makes you feel dizzy, stop what you're doing and sit or lie down until you feel better
  • feeling tired or weak- if Aserin makes you feel tired or weak, stop what you're doing and sit or lie down until you feel better. Do not drive or use tools or machinery if you're feeling tired. Do not drink alcohol as it'll make you feel worse. If these symptoms don't go away after a week or two, ask your pharmacist or doctor for advice.


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