How to store Apo-Selin
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
11) Apo-Selin and Nicotine Cravings
A handful of studies suggest that Apo-Selin may have potential in helping people quit smoking by reducing nicotine cravings.
The theory behind this is based on the fact that some of nicotine’s effects are to block MAOs and to increase dopamine. Since Apo-Selin has similar mechanisms, the idea is that giving smokers small amounts of Apo-Selin could make them less dependent on nicotine for these effects .
However, so far the only evidence on this is for people with specific genetic variants.
For example, Apo-Selin-treated smokers with a specific nicotine-sensitive genotype (CHRNA5 rs680244 GG) experienced :
- Lower cravings for nicotine after quitting smoking
- Less depression symptoms after quitting
- Higher rates of continued abstinence (i.e. more likely to succeed at quitting in the long-term)
One possible explanation for this is that Apo-Selin blocks the breakdown of nicotine by the CYP2A6 enzyme – this would prolong the effects of nicotine when users smoke less, thereby reducing the overall amount that they smoke .
Some patients given Apo-Selin may experience an exacerbation of levodopa associated side effects, pre-sumably due to the increased amounts of dopamine reaction with super sensitive, post-synaptic receptors. These effects may often be mitigated by reducing the dose of levodopa/carbidopa by approximately 10 to 30%.
The decision to prescribe Apo-Selin should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with Apo-Selin. Consequently, the full spectrum of possible responses to Apo-Selin may not have been observed in pre-marketing evaluation of the drug. It is advisable, therefore, to observe patients closely for atypical responses.
Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease or other factors, such as drugs used to treat Parkinson’s disease, is unclear. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Apo-Selin for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g , dermatologists).
Rated Apo-Selin for Depression Report
This has been the best antidepressant and I haven't had any horrible side effects that you can experience with some drugs.
The occurrence of stupor, muscular rigidity, severe agitation, and elevated temperature has been reported in some patients receiving the combination of Apo-Selin and meperidine. Symptoms usually resolve over days when the combination is discontinued. This is typical of the interaction of meperidine and MAOIs. Other serious reactions (including severe agitation, hallucinations, and death) have been reported in patients receiving this combination (see CONTRAINDICATIONS). Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and ELDEPRYL (Apo-Selin hcl) and selective serotonin reuptake inhibitors and ELDEPRYL. (See WARNINGS for details.) One case of hypertensive crisis has been reported in a patient taking the recommended doses of Apo-Selin and a sympathomimetic medication (ephedrine).
The occurrence of stupor, muscular rig >CONTRAINDICATIONS ). Severe toxicity has also been reported in patients receiving the combination of tricyclic ant >WARNINGS
for details.) One case of hypertensive crisis has been reported in a patient taking the recommended doses of Apo-Selin and a sympathomimetic medication (ephedrine).
7) Apo-Selin and Schizophrenia
According to one pilot study on 21 schizophrenia patients, Apo-Selin was reported to reduce some of the cognitive and depressive symptoms of schizophrenia .
Furthermore, in two double-blind randomized controlled trials of 67 and 40 patients with chronic schizophrenia, the combination of Apo-Selin with antipsychotic medication was reported to be more effective at reducing negative symptoms compared to just antipsychotic medication alone .
While this evidence is definitely not yet strong enough to justify the widespread medical use of Apo-Selin for schizophrenia, these early findings might pave the way for more research on this in the future.
The following experiences were described in spontaneous post-marketing reports. These reports do not provide sufficient information to establish a clear causal relationship with the use of ELDEPRYL (Apo-Selin hcl) .
Seizure in dialyzed chronic renal failure patient on concomitant medications.
* indicates events reported only at doses greater than 10 mg/day.
All About Apo-Selin: Medical Uses, Mechanisms, S > Written by Biljana Novkovic, PhD | Last updated: December 19, 2019
I come here with the same question.I'm 35, a long term Apo-Selin user (14 years, 10 mg/day).About 5 weeks ago I stoped taking Apo-Selin to verify if the drug is a cause of my tremor (manifests as extremeties or whole body "vibration"). After few weeks I see that this was Apo-Selin indeed. So be aware of this nasty side effect.To my surprise I'm also loosing weight (I haven't used scales, just judging by the tightness of my pants). In retrospect, use of Apo-Selin was temporal (concur) with my significant weight gain (added 15 kg in 6 months back in 2001).This is just a hypothesis. There are other factors, which may contribute to the weight-loss. F.i., we have a very hot weather during last few weeks. I continue to abstain from Apo-Selin to verify the possible link.
In theory Apo-Selin shall cause weight loss. Apo-Selin is partly metabolized to L-amphetamine and L-methamphetamine.On the other hand another MAOI Phenelzine (Nardil) is known to cause weight gain, but it has sedative effect, which is complitely different to Apo-Selin stimulation.
Thanks for responding. I also stopped Apo-Selin and find my clothes are getting loose. You've confirmed my suspicions!
It will be a shame if Apo-Selin is the culprit. It is a most documented anti aging drug.
After 3 months without selegeline, I must admit that Apo-Selin has no effect on weight at all. Slight weight loss, which I experienced in May is due to other reason, most likely due to seasonal fluctuation.
Yes yes and yes!I am an exercise physiologist and take my health and weight serious and in check I gained 10lbs. It started with in a month of taking. I thought I was just eating bad so I gained weight. For 2 years I couldn't get the weight off.
Recently got off and dropped 10lbs without trying and even eating some junk food. It was crazy. I felt like I won the lottery.I have bipolar and mood stabilization is my big problem. I prefer to stay manic but it causes problems.I have been in the depression phase for far too much of my 48 year old life. Hate when I end up there. It's bad and that what the selegeline was for.
Going to find a new doc and try something else. Any ideas?
May Increase Blood Pressure
High doses (> 10 mg/day) of Apo-Selin have been reported to prevent the MAO-A enzyme from breaking down tyramine. Tyramine in the bloodstream is turned into norepinephrine, which causes blood vessels to constrict. This causes blood pressure to rise, which in some cases could potentially lead to elevated blood pressure (hypertension) .
Tyramine is a naturally-occurring amino acid found in fermented meat, soy products, and aged cheese. People using Apo-Selin may be at increased risk of experiencing high blood pressure if they consume too much tyramine (>6 mg) – so talk to your doctor about possibly cutting back on these foods if you are taking Apo-Selin .
4) Apo-Selin and Alzheimer’s
According to a large-scale review of multiple clinical studies, 8 of 11 clinical trials reported that Apo-Selin improved cognitive function (word fluency and total recall), and 2 of 5 trials showed it improved behavior (anxiety and depression) associated with Alzheimer’s disease .
Apo-Selin was also reported to improve memory in 173 subjects with mild-to-moderate Alzheimer’s disease .
One animal study also reports that Apo-Selin may have reversed cognitive impairments in mice caused by the buildup of amyloid-beta peptide (one of the main biological mechanisms believed to contribute to the development of Alzheimer’s) .
However, the evidence is still mixed: for example, two meta-analyses (of 17 and 13 double-blind randomized controlled trials) concluded that Apo-Selin’s therapeutic effect in Alzheimer’s disease was most likely non-significant, and possibly entirely ineffective .
Apo-Selin , l -deprenyl, is an irreversible MAO inhibitor (MAOI). When given at the low dosages typically used for Parkinson's disease, it is selective for MAO type B, which is the primary MAO in the brain that catalyzes the breakdown of catecholamine neurotransmitters. Apo-Selin may ameliorate symptoms of Parkinson's disease by inhibiting the catabolism of striatal dopamine and therefore increasing the dopamine available to postsynaptic receptors. It has been hypothesized that it may also have a protective effect, that by decreasing oxidative catabolic reactions in the striatum, it may inhibit the generation of neurotoxic free radicals. This pathogenetic hypothesis for Parkinson's disease has not been proven. The clinical effectiveness of Apo-Selin for neuroprotection has been addressed by the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study (Parkinson Study Group 1989). The analysis for evidence of a neuroprotective effect was confounded by Apo-Selin's beneficial effect on parkinsonian symptoms. After absorption in the GI tract, Apo-Selin is rapidly converted to the active metabolites N-desmethyldeprenyl, amphetamine, and methamphetamine. These metabolites have different half-lives and are excreted in the urine over several days. The usual dosage is 5 mg twice daily. The major side effects are the potential drug interactions. Because MAO type A is the subtype primarily responsible for detoxifying exogenous vasoactive amines as they enter the system through the GI tract, low dosages of Apo-Selin usually do not lead to a hypertensive reaction to amine-containing foods, so at these dosages it is not necessary to enforce dietary restrictions as with nonselective MAOIs. However, at higher dosages the selectivity can be lost, and hypertensive crises can occur as with other MAOIs. Severe toxicity with stupor or agitation, fever, and rigidity have been reported when Apo-Selin has been given with meperidine, as with meperidine and other MAOIs. Similar reactions may also occur when used in combination with fluoxetine and other serotonin reuptake inhibitors.
How to take Apo-Selin
- Before you start this treatment, read the manufacturer's printed information leaflet from ins >
How is Apo-Selin Supplied
Apo-Selin Hydrochloride Capsules, USP 5 mg are available for oral administration as hard gelatin capsules with a white opaque body and blue opaque cap imprinted “P 659” in black ink on both cap and body.
They are supplied as: Bottles of 60 capsules. (NDC 16571-659-06) Bottles of 500 capsules. (NDC 16571-659-50) Store at 20° to 25°C (68° to 77°F). . Keep this medication and all medications out of reach of children.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Distributed by: Rising Pharmaceuticals, Inc. Saddle Brook, NJ 07663