Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction to Amyzol.
Do not stop taking Amyzol suddenly, or without talking to your doctor.
Amyzol can change how hungry you feel. Some people feel more hungry when they're taking it - others feel less hungry. So your weight may change when you first start taking it.
If you start to have problems with your weight while taking Amyzol, talk to your doctor or pharmacist
Some people feel sleepy while they're taking Amyzol. It might be best to stop driving and cycling for the first few days of treatment until you know how this medicine makes you feel.
Antidepressants like Amyzol are just one of several ways to treat nerve pain or prevent migraine. Other treatments include:
- painkillers such as paracetamol
- medicines that are usually used for epilepsy such as pregabalin
- medicines that are usually used to treat high blood pressure such as propranolol
Choosing a treatment that's most suitable for you depends on:
- how long you've had the pain
- your symptoms
- what medicines have worked or not worked for you in the past
You can drink alcohol while taking Amyzol but it may make you feel sleepy. It might be best to stop drinking alcohol until you see how the medicine makes you feel.
You can eat and drink normally while taking Amyzol.
Amyzol does not affect any type of contraception including contraceptive pills and the morning after pill.
Some people have sex-related problems while they take Amyzol. They include:
- men having problems with getting an erection and problems with ejaculating
- women having some vaginal bleeding
- both men and women having breast swelling
Sexual side effects are not common and should pass after the first couple of weeks. If they don't, and this is a problem for you, go back to your doctor to see if there's another medicine you can try.
If you're a woman and you get vaginal bleeding after the menopause, make an appointment to see your doctor as soon as possible.
Amyzol doesn't affect male or female fertility.
Cannabis with Amyzol can make you feel very sleepy, especially if you've just started taking Amyzol. Cannabis with Amyzol can also give you a fast heartbeat.
It can be potentially dangerous to take Amyzol with:
- stimulants like MDMA (ecstasy) or cocaine
- hallucinogens like LSD
- novel psychoactive substances (which used to be known as legal highs) like mephedrone
Amyzol hasn't been properly tested with recreational drugs. Talk to your doctor if you think you might use recreational drugs while taking Amyzol.
NMDA Antagonist Activity
Repetitive small afferent nociceptive input into the dorsal horn of the spinal cord may lead to facilitated processing of nociceptive signals involving NMDA receptor complexes, which may be appreciated behaviorally as hyperalgesia. 70,71 The processes previously discussed may be ameliorated by the intrathecal administration of NMDA antagonists. 72
The intrathecal administration of NMDA induces a thermal hyperalgesia, which may be reversed by NMDA antagonists 73 as well as by intrathecal Amyzol . 74 Also, NMDA antagonists and Amyzol may diminish the hyperalgesia phase 2 (but not phase 1 ) of the formalin-induced tissue injury model. 75 Intrathecal Amyzol acts functionally as an NMDA antagonist in the presence of rat cutaneous inflammation-induced thermal hyperalgesia. 74 Intrathecal NMDA antagonists and intrathecal Amyzol have been demonstrated to reduce thermal hyperalgesia (rodent Bennett model) and tactile allodynia (rodent Chung model). 76
When Amyzol and desipramine are coadministered peripherally with formalin, both the first- and the second-phase responses are reduced. When Amyzol is administered peripherally along with formalin, Fos immunoreactivity in the dorsal region of the spinal cord is significantly lower than in animals in which formalin is administered alone.
Hi, yes it is. Have you taken this amount? The symptoms you would probably experience first hand would be;sinus tachycardia, hot dry skin, dry mouth and tongue, dilated pupils and urinary retention. An overdose of Amyzol is more dangerous if taken at doses of 750mg upwards but 400mg is still dangerous. I take this med and i am on 50mg a night, which is considered a reasonably high dose.Check out this website for a full list of side effects/overdose effects; http://www.mhra.gov.uk If you have taken an overdose contact your doctor or nearest ER now!
Amyzol hasn’t been properly tested when taken with recreational drugs, but some drugs are known to react with it.
Cannabis can make you feel very sleepy and can also make your heart beat very fast.
Drugs with potentially dangerous interactions include:
- stimulants like MDMA, ecstasy or cocaine
- hallucinogens like LSD
- novel psychoactive substances – the new term for ‘legal highs’ – like mephedrone.
Speak to your doctor before starting Amyzol if you use a recreational drug that may interact with it.
The FDA requires Amyzol to carry a black-box warning because of the risk of suicide.
In short-term studies, a small number of children, teen-agers and young adults (up to 24 years old) who took antidepressants such as Amyzol became suicidal shortly after starting treatment.
You may have suicidal thoughts while taking an antidepressant, especially if you are younger than 24 years old.
Your family members or other caregivers should watch for changes in your mood or other symptoms.
You, a family member, or caregiver should tell your doctor right away if you experience any of the following symptoms while taking Amyzol (especially during the first weeks of treatment or any time you change your dose):
- Thoughts of harming or killing yourself
- Worsening depression
- Extreme worry or other new feelings of anxiousness
- Panic attacks
- Difficulty falling asleep or staying asleep
- Aggressive behavior
- Unusual restlessness
- Unusual mood or behavior changes
- Unusual excitement or hyperactivity
- Agitation, hostility, or aggressiveness
- Unusually impulsive behavior
Children under age 18 should not take Amyzol, but in rare cases, a doctor may decide the benefits outweigh the risks.
Before having any type of surgery, you should tell your surgeon that you are taking Amyzol.
You may also need to make a plan with the doctor who prescribed the drug to carefully taper off before surgery.
You should not stop taking Amyzol suddenly, as you could experience withdrawal symptoms.
It may take a few weeks before you feel the full effects of this medication.
Use this drug as directed, stay in touch with your doctor during your treatment for depression, and tell your doctor if Amyzol isn't helping after four weeks.
Before taking Amyzol, you should tell your doctor if you have any of the following conditions:
- Heart disease
- A history of heart attack, stroke, or seizures
- A history of drinking large amounts of alcohol
- Bipolar disorder (manic depression), schizophrenia, or any other mental illness
- Overactive thyroid
- An enlarged prostate
- Urination problems
Q: Is Amyzol harmful? I have seen bad reviews for this drug, but it is the only drug that helps me for depresson.
A: Elavil (Amyzol) (//www.everydayhealth.com/drugs/Amyzol) belongs to a group of drugs called tricyclic antidepressants. Amyzol is used for depression and may be used by other conditions by the doctor. (//www.everydayhealth.com/depression/guide/). Common side effects of Amyzol include dry mouth, loss of appetite, dizziness, drowsiness, and blurred vision. Other side effects may include trouble concentrating, nightmares, and a decreased sex drive. This is not a complete list of the side effects associated with Amyzol. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting //www.fda.gov/Safety/MedWatch/default.htm or by calling 1-800-FDA-1088. Kimberly Hotz, PharmD.
More common side effects
The more common side effects of Amyzol can include:
- numbness and tingling in your arms and legs
- constipation or diarrhea
- blurred vision
- skin rash
- swelling of your face and tongue
- unexpected weight gain or loss
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Q: Is there any correlation between Amyzol and memory loss?
A: Amyzol may cause drowsiness, confusion, and difficulty thinking and concentrating. Studies have shown that impairments on memory tasks can occur in patients taking Amyzol. For more information about Amyzol and memory loss, please consult with your healthcare practitioner and visit //www.everydayhealth.com/drugs/Amyzol.
Rated Amyzol (Elavil) for Post Traumatic Stress Disorder Report
I was prescribed this from my Psychiatrist. 25 mgs. HCL @ bedtime only. I was awake all night. Also, for Insomnia. This is the 2nd change for me this month. First medication was horrible, I was walking around all night long. Been more depressed, cannot sleep and I am uncomfortable calling her again. I was on Ambien for years and my Medicare thinks I will fall from use to be my Ambien.