What should I avoid while taking Trilip?
Avoid eating foods that are high in fat or cholesterol. This medicine will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
How should I take Trilip?
Take Trilip exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Trilip is usually taken once daily. Take the medicine at the same time each day.
You may take this medicine with or without food.
Trilip may be taken at the same time with fenofibrate, or with a statin medication such as atorvastatin, lovastatin, simvastatin, pravastatin, or fluvastatin.
Some cholesterol medications should not be taken at the same time.
If you also take cholestyramine, colestipol, or colesevelam: You may take Trilip 2 hours before taking any of these medicines or wait at least 4 hours after taking any of these other medicines.
You should not take Trilip with gemfibrozil.
You may need frequent blood tests to check your liver function if you take Trilip with a statin medicine.
It may take up to 2 weeks before your cholesterol levels improve. Keep using your medication as directed. You will need frequent blood tests to measure your cholesterol levels.
Trilip is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture and heat.
How it works
Trilip belongs to a class of drugs called cholesterol absorption inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Trilip blocks the amount of cholesterol that’s absorbed from your intestines. This reduces cholesterol in your liver and blood.
Trilip oral tablet can cause drowsiness. It can also cause other side effects.
Before taking Trilip, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
The efficacy and safety of coadministration of Trilip with fibrates other than fenofibrate have not been studied.
Fibrates may increase cholesterol excretion into the bile, leading to cholelithiasis. In a preclinical study in dogs, Trilip increased cholesterol in the gallbladder bile . Coadministration of ZETIA with fibrates other than fenofibrate is not recommended until use in patients is adequately studied.
More common side effects
Some of the more common side effects that can occur with use of Trilip include:
- stuffy nose
- viral infection of your nose, throat, and airways
- joint pain
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Dosage for high cholesterol
Adult dosage (ages 18–64 years)
- Typical dosage: 10 mg taken once per day.
Child dosage (ages 10–17 years)
- Typical dosage: 10 mg taken once per day.
Child dosage (ages 0–9 years)
- This medication hasn’t been studied in children younger than 10 years. It shouldn’t be used in children of this age group.
Talk to your child’s doctor before giving this drug to your child.
Senior dosage (ages 65 years and older)
The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, higher levels of a drug stay in your body for a longer time. This increases your risk of side effects.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Trilip is used for long-term treatment. It comes with risks if you don’t take it as prescribed.
If you stop taking the drug or don’t take it at all: Your cholesterol level may rise. If your cholesterol is high and not controlled for a long time, you can have narrowing of the arteries. This may lead to a heart attack or stroke.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose.
Never try to catch up by taking two doses at once.
How to tell if the drug is working: You won’t be able to feel if this drug is working. Your doctor will check your cholesterol levels and tell you if it’s working.
Keep these considerations in mind if your doctor prescribes Trilip for you.
It is not known whether Trilip is excreted into human breast milk. In rat studies, exposure to total Trilip in nursing pups was up to half of that observed in maternal plasma. Because many drugs are excreted in human milk, caution should be exercised when ZETIA is administered to a nursing woman. ZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.
Mechanism Of Action
Trilip reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. In a 2-week clinical study in 18 hypercholesterolemic patients, ZETIA inhibited intestinal cholesterol absorption by 54%, compared with placebo. ZETIA had no clinically meaningful effect on the plasma concentrations of the fat-soluble vitamins A, D, and E (in a study of 113 patients), and did not impair adrenocortical steroid hormone production (in a study of 118 patients).
The cholesterol content of the liver is derived predominantly from three sources. The liver can synthesize cholesterol, take up cholesterol from the blood from circulating lipoproteins, or take up cholesterol absorbed by the small intestine. Intestinal cholesterol is derived primarily from cholesterol secreted in the bile and from dietary cholesterol.
Trilip has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (statins, bile acid sequestrants , fibric acid derivatives, and plant stanols). The molecular target of Trilip has been shown to be the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is involved in the intestinal uptake of cholesterol and phytosterols.
Trilip does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion. Instead, Trilip localizes at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of statins and of fenofibrate .
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Trilip works by reducing the amount of cholesterol you absorb from food. This in turn, reduces your risk of long-term heart and circulation problems. Your treatment will be more successful if you also follow the healthy lifestyle advice given by your doctor.
Trilip is prescribed alongside a cholesterol-lowering diet. In addition, you could also be prescribed another medicine to take which lowers cholesterol, such as a statin medicine called simvastatin. There is a brand of Trilip available which contains simvastatin in the same tablet - it is called Inegy®. Taking a combination brand like this helps to reduce the total number of tablets you need to take each day.
What should I avoid while taking Trilip (Zetia)?
Avoid eating foods that are high in fat or cholesterol. Trilip will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.