Triglyx tablets

Triglyx

  • Active Ingredient: Atorvastatin
  • 40 mg, 20 mg, 10 mg, 5 mg
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What is Triglyx?

The active ingredient of Triglyx brand is atorvastatin. Atorvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Atorvastatin calcium is a white to off-white colored powder free from visible extraneous matter. Atorvastatin calcium is soluble in dimethyl sulphoxide, slightly soluble in alcohol, very slightly soluble in water, in pH 7.4 phosphate buffer and in acetonitrile and practically insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium tablets for oral administration contain 10, 20, 40, or 80 mg Atorvastatin and the following inactive ingredients: anhydrous lactose, NF; colloidal silicon dioxide, NF; copovidone, NF; croscarmellose sodium, NF; magnesium stearate, NF; mannitol, USP; silicified microcrystalline cellulose, NF; sodium bicarbonate, USP; sodium carbonate anhydrous, NF; sodium lauryl sulfate, NF; lecitihin, polyvinyl alcohol part hydrolyzed, talc, titanium dioxide, xanthan gum.

Used for

Triglyx is used to treat diseases such as: High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease, Rheumatoid Arthritis.

Side Effect

Possible side effects of Triglyx include: unable to move or feel face; fever; sores, ulcers, or white spots in the mouth or on the lips; pain or tenderness around the eyes and cheekbones; bloody or cloudy urine; painful or difficult urination.

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How much to take

The usual dose for adults is between 10mg and 80mg a day.

In children, the usual dose is 10mg to 20mg once a day. Your doctor will use your child's age to work out the amount of Triglyx that's right for them.

Your dose depends on the reason for taking it, your cholesterol levels, and what other medicines you're taking. Ask your doctor or pharmacist for advice if you're unsure how much to take. Don't reduce your dose without talking to your doctor first.

Antibiotics

Taking Triglyx with certain antibiotics increases your risk for muscle problems. Examples of these drugs include:

  • Muscle problems warning: Your risk for rhabdomyolysis (muscle breakdown) is increased while taking Triglyx. The risk is greater if you’re a senior, have thyro >

Triglyx oral tablet is a prescription drug. It’s available as a brand-name drug called Lipitor. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Dosage Considerations of Lipitor

Co-administration of this medication with other drugs

  • Bile acid sequestrant: Administer medication Triglyx/ezetimibe 2 hours or more before or 4 hours or more after administering bile acid sequestrant
  • Cyclosporine, tipranavir plus ritonavir, telaprevir, gemfibrozil: Avoid co-administration with Triglyx (increased risk of rhabdomyolysis)
  • Lopinavir plus ritonavir: Use lowest dose of medicine necessary
  • Clarithromycin, itraconazole, saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir: Do not exceed Triglyx dose of 20 mg/day
  • Nelfinavir, boceprevir: Do not exceed Triglyx dose of 40 mg/day

  • This medication is generally considered safe in acute overdose, although not formally studied
  • Adverse drug reactions and side effects from overdose may include peripheral neuropathy, diarrhea, increased K+, myopathy, rhabdomyolysis, acute renal failure, elevated LFTs, eyelens opacities
  • Treatment is supportive

Which drugs or supplements interact with Lipitor (Triglyx)?

Decreased elimination of Lipitor could increase levels of Lipitor in the body and increase the risk of muscle toxicity from Lipitor. Therefore, Lipitor should not be combined with drugs that decrease its elimination. Examples of such drugs includes:

Large quantities of grape fruit juice (>1.2 liters daily) also will increase blood levels of Lipitor and should not be taken.

The following drugs also may increase the risk of muscle toxicity when combined with Lipitor.

Lipitor increases the effect of warfarin (Coumadin) and the concentration in blood of digoxin (Lanoxin). Patients taking Lipitor and warfarin or digoxin should be monitored carefully. Cholestyramine (Questran) decreases the absorption of Lipitor. Lipitor should be given at least two hours before and at least four hours after cholestyramine.

Rifampin increases breakdown of Lipitor. To reduce the likelihood of this interaction both drugs should be given at the same time. Lipitor should not be given after rifampin.

Triglyx, marketed under the trade name Lipitor among others, is a member of the drug class known as statins, which are used primarily as a lipid-lowering agent and for prevention of events associated with cardiovascular disease.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of LIPITOR. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Adverse reactions associated with LIPITOR therapy reported since market introduction, that are notlisted above, regardless of causality assessment, include the following: anaphylaxis, angioneurotic edema, bullous rashes (including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), rhabdomyolysis, myositis, fatigue, tendon rupture, fatal and non-fatal hepatic failure, dizziness, depression, peripheral neuropathy, pancreatitis and interstitial lung disease.

There have been rare reports of immune-mediated necrotizing myopathy associated with stat in use .

There have been rare postmarketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports aregenerally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) andsymptom resolution (median of 3 weeks).

Read the entire FDA prescribing information for Lipitor (Triglyx Calcium)

Clinical monitoring

While you’re being treated with Triglyx, your doctor will check your cholesterol levels and liver function. This will be done through blood tests.


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