Dosage for reducing the risk of heart disease and heart attack and stroke in people with heart disease
Adult dosage (ages 18 years and older)
- Typical starting dosage: Simvotin is often started at 10–20 mg per day. However, the dosage may range from 5 mg to 40 mg per day. You should take this drug once a day in the evening.
- Dosage increases: Your doctor will gradually adjust your dosage if needed.
Child dosage (ages 10–17 years)
- Typical starting dosage: 10 mg per day.
- Note: Doses above 40 mg per day have not been studied in this age group.
Child dosage (ages 0–9 years)
This medication has not been studied in children below age 10 years.
Q: How do I take Zocor?
A: To take Zocor (Simvotin), to lower cholesterol and reduce the risk for coronary heart disease and cardiovascular events, it is essential for patients to take Zocor exactly as directed by their health care provider. To exert its maximal benefits, Zocor must be taken regularly. Zocor is typically administered once daily in the evening in a dosing range of 5 to 80 mg per day depending on the approved indication for use, age of the patient and any other medical conditions or medications a patient currently takes. To take Zocor effectively, it is important for patients to take it at the same time every day. Patients may take Zocor without regard to food. Zocor is intended to be only one component of a complete program of treatment which also includes diet, exercise, and weight management. Patients are advised to discuss an appropriate diet and exercise regimen, in conjunction with Zocor treatment, with their health care provider. To take Zocor effectively, patients should be advised to avoid eating foods that are high in fat or cholesterol. Zocor will not be as effective in lowering cholesterol if patients do not follow a cholesterol-lowering plan simultaneously. To take Zocor effectively, patients are also advised to avoid drinking alcohol during treatment. In addition to the potential for alcohol to increase triglyceride levels, it may also increase a patient's risk of liver toxicity possible with treatment with Zocor. Patients should also be advised not to eat grapefruit or drink grapefruit juice while they take Zocor. Grapefruit and grapefruit juice interact with Zocor and may increase a patients risk for adverse reactions. To take Zocor safely, it is important for health care providers to routinely monitor a patient's cholesterol levels and liver function to ensure the medication is working optimally and not causing any adverse reactions involving the liver.
Pregnancy and Lactation
Do not use this drug in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
Simvotin is contraindicated while breastfeeding; it is potentially unsafe.
Q: I am taking 40 mg of Zocor daily. I have high triglycerides, low HDL and low LDL readings. Should I be taking this medication since it is a cholesterol lowering drug and my cholesterol readings are already low? Does it do anything for my high triglyceride readings?
A: About 90% of the cholesterol-lowering drugs taken by Americans are in a class of medications known as statins. Zocor (Simvotin) is a hypolipidemic medication, a statin, (HMG-CoA reductase inhibitor) used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular disease.These drugs lower cholesterol by at least 20% through the same basic action. They inhibit HMG-CoA reductase, a key enzyme that controls how much cholesterol is produced in the liver. The result is lower blood levels of LDL cholesterol. Statins also lower elevated triglycerides and raise HDL ("good") cholesterol. For more specific information, consult with your doctor or pharmacist for recommendations based on your specific condition and current medications. Shereen A. Gharbia, PharmD
Serious side effects
It happens rarely, but less than 1 in 1,000 people taking Simvotin may have a serious side effect.
Stop taking Simvotin and call a doctor if you get:
- muscle pain, tenderness, weakness or cramps - these can be signs of muscle breakdown and kidney damage
- yellow skin or the whites of your eyes turn yellow, or if you have pale poo and dark pee - this can be a sign of liver problems
- a skin rash with pink-red blotches, especially on the palms of the hands or soles of the feet
- severe stomach pain - this can be a sign of pancreas problems
- a cough, feeling short of breath, and weight loss - this can be a sign of lung disease