SimvaHEXAL tablets


  • Active Ingredient: Simvastatin
  • 40 mg, 20 mg, 10 mg
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What is SimvaHEXAL?

The active ingredient of SimvaHEXAL brand is simvastatin. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Simvastatin USP is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol. Simvastatin tablets USP for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of Simvastatin and the following inactive ingredients: ascorbic acid, butylated hydroxy anisole, citric acid anhydrous, hydroxypropyl cellulose, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinised starch, and titanium dioxide.

Used for

SimvaHEXAL is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of SimvaHEXAL include: blurred vision; Bladder pain; chills; lack or loss of strength; difficulty with breathing.

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Warfarin (blood thinner)

When taken with warfarin, SimvaHEXAL can increase the blood-thinning effects of warfarin. This can lead to an increased risk of bleeding. Your doctor monitor your warfarin level more closely if you’re taking these two drugs at the same time.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Before taking this medicine

You should not take this medicine if you are allergic to SimvaHEXAL, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with SimvaHEXAL. These drugs should not be used while you are taking this medicine:

an antibiotic--clarithromycin, erythromycin, telithromycin;

antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

hepatitis C medications--boceprevir, telaprevir; or

HIV/AIDS medication--atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking SimvaHEXAL, tell your doctor if you are already using any of these other medicines:

heart medication--amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure SimvaHEXAL is safe for you, tell your doctor if you have:

history of liver disease;

history of kidney disease;

a thyroid disorder; or

if you drink more than 2 alcoholic beverages daily.

SimvaHEXAL can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take SimvaHEXAL if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Clinical monitoring

While you take SimvaHEXAL, your doctor will want to make sure that it isn't affecting your liver and kidneys. Your doctor may perform a baseline liver function test (an initial liver function test that is repeated in a few months). They may also do additional liver and kidney function tests during treatment.

What Is SimvaHEXAL and How Does It Work?

SimvaHEXAL (Zocor) is a, FDA approved prescription medication that is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." Statins are medications that work by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. This drug maybe used to treat other diseases and conditions. Your doctor may conduct liver function tests when using statins to monitor liver enzymes and other liver function.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help SimvaHEXAL medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

This medication is available under the following different brand names: Zocor.

What if I take too much?

Taking an extra dose of SimvaHEXAL by accident is unlikely to harm you.

Talk to your pharmacist or doctor if you're worried or if you take more than 1 extra dose.

SimvaHEXAL seems to be a very safe medicine and it's unusual to have side effects. However, different statins can affect people in different ways.

Talk to your doctor or pharmacist if side effects bother you or don't go away. They may recommend taking a different statin.

One rare but serious side effect is unexplained muscle aches and pains. This is more likely if you're taking a higher dose of SimvaHEXAL - and it can happen a few weeks or months after you first start taking this medicine. Report any unexplained muscle pain, tenderness or weakness to a doctor straight away.

Another very rare side effect can be memory loss. This usually goes away when you stop taking the medicine.

Q: I would like to know if lowering my colesterol medication by 1/2 to 1/4 and taking at least 200 mg of coenzyme Q10 would be helpful? I am taking 40 mg of Zocor, and read a study that suggests decreasing that amount and supplementing with coenzyme Q10 would be very beneficial to counter the side effects of the Zocor.

A: Zocor (SimvaHEXAL) is in a drug class called statins (HMG-CoA reductase inhibitors). Zocor is used in combination with diet, weight loss and exercise to improve cholesterol and other harmful fatty substances in the blood. Because of Zocor's beneficial effects on cholesterol and other fatty substances in the blood, Zocor is used to reduce the risk of dying, by reducing heart disease deaths, in people at a high risk of having an adverse heart event. Zocor is also used to reduce the risk of heart attack, stroke, and needing certain heart procedures in people at high risk of an adverse heart event. Zocor works by slowing down the amount of cholesterol made by the body. The most common side effects with Zocor are: upper respiratory infection, headache, abdominal pain, constipation, and nausea. Other side effects with Zocor include diarrhea; inflammation of the lining of the stomach; upset stomach; excessive gas; malaise; muscle cramps; muscle pain; and joint pain. In some instances, Zocor may cause myopathy (disease of the muscle), which in rare cases could lead to a serious condition called rhabdomyolysis (breakdown of muscle fibers) and potentially acute kidney failure. The risk of this happening is increased when people take certain other types of medications or drink larger quantities of grapefruit juice. Predisposing factors include: older age (?65 years), uncontrolled hypothyroidism, and kidney impairment. Symptoms include muscle pain, tenderness, and weakness. Coenzyme Q10 is naturally occurring substance found in the body -- namely the heart, liver, kidney, and pancreas. Coenzyme Q10 can be found in small amounts in meat and seafood. Coenzyme Q10, as a dietary supplement, is promoted for a wide array of medical conditions including heart disease; diabetes; breast cancer; and HIV/AIDS. Scientific evidence suggests that coenzyme Q10 is likely effective for coenzyme Q10 deficiency and mitochondrial disorders (disorders that minimize energy production in the cells of the body). There is some scientific evidence that coenzyme Q10 is effective for lowering blood pressure, preventing migraines, and slowing the decline in people with early stage Parkinson's disease. There appears to be insufficient scientific evidence to support the use of coenzyme Q10 in treating cholesterol disorders. Some information suggests that taking coenzyme Q10 along with statins may reduce the risk of rhabdomyolysis. Also, small reports suggest that coenzyme Q10 may reduce muscle pain and joint aches associated with the use of statins; however, not all evidence show a benefit. Furthermore, no large clinical study has confirmed that coenzyme Q10 can prevent or lessen side effects from statins. Current expert guidelines do not recommend the use of coenzyme Q10 in people taking statins. Because dietary supplements (e.g., coenzyme Q10) are not strictly regulated by the U.S. Food and Drug Administration, these products are not required to be tested for effectiveness, purity, or safety. Also because dietary supplements have not been thoroughly studied in the clinical setting, possible side effects and interactions with other drugs are not well known. Also, because herbs and supplements In general, dietary supplements should only be taken under the supervision of your health care provider. People should report any potential side effects from Zocor, including muscle and joint pain -- particularly if associated with fatigue. Derek Dore, PharmD


Zocor (SimvaHEXAL) belongs to the drug class of statins and is prescribed for lowering cholesterol and triglyceride levels. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • rhabdomyolysis (muscle breakdown)
  • severe muscle pain or weakness
  • muscle spasms
  • kidney failure
  • liver toxicity
  • jaundice (yellowing of the skin)
  • severe anemia
  • severe allergic reaction, with symptoms such as fever and trouble breathing
  • rash of any kind
  • extreme sensitivity to the sun
  • diarrhea
  • feeling weak or very tired
  • severe stomach pain
  • severe nausea or vomiting
  • severe swelling of the hands, feet, and ankles

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we can not guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Can taking SimvaHEXAL increase my risk of diabetes?

There is a small risk of increased blood sugar levels and even diabetes from taking SimvaHEXAL. Your doctor should occasionally check your blood sugar levels while you take SimvaHEXAL. If you already have diabetes, your doctor should regularly check your blood sugar level. Your doctor should also regularly check your hemoglobin A1C level, which can indicate if your average blood sugar level has been high over an extend period (2–3 months).

Healthline Pharmacist Review Team Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

SimvaHEXAL oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with SimvaHEXAL are listed below.

7. Cautions with other medicines

Some medicines don't mix well with SimvaHEXAL, including:

  • some antibiotics and antifungals
  • some HIV medicines
  • some hepatitis C medicines
  • warfarin (stops blood clotting)
  • ciclosporin (treats psoriasis and rheumatoid arthritis)
  • danazol (treats endometriosis)
  • nefazodone (treats depression)
  • amiodarone (makes your heart stable)
  • verapamil, diltiazem, amlodipine (for high blood pressure and heart problems)

If you're taking SimvaHEXAL and need to take one of these medicines, your doctor may:

  • prescribe a lower dose of SimvaHEXAL
  • prescribe a different statin medicine
  • recommend that you temporarily stop taking your SimvaHEXAL

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