Simvacor tablets


  • Active Ingredient: Simvastatin
  • 40 mg, 20 mg, 10 mg
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What is Simvacor?

The active ingredient of Simvacor brand is simvastatin. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Simvastatin USP is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol. Simvastatin tablets USP for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of Simvastatin and the following inactive ingredients: ascorbic acid, butylated hydroxy anisole, citric acid anhydrous, hydroxypropyl cellulose, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinised starch, and titanium dioxide.

Used for

Simvacor is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Simvacor include: body aches or pain; belching; red skin lesions, often with a purple center; skin rash, hives, or itching; unusual tiredness or weakness; constipation; sweating.

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Q: What is Zocor?

A: Zocor (Simvacor) is a prescription medication used for treating a number of conditions related to heart disease including high cholesterol and triglycerides. This medication is part of a class of drugs called statins. It works by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. For more information on Zocor: // Lori Poulin, PharmD

Do not exceed 10 mg Simvacor daily with:

(Note: These drugs are contraindicated with Simcor as Simcor is only available with 20 mg or 40 mg of Simvacor.)

Do not exceed 20 mg Simvacor daily with:

  • Amiodarone
  • Verapamil

Q: How badly does 80 mg of Zocor attack the liver?

A: Zocor (Simvacor) is a cholesterol-lowering drug that belongs to the group of drugs known as HMG CoA reductase inhibitors, more commonly referred to as statins. Statins work by interfering with how your liver produces cholesterol. The most common side effects include bowel irregularity and mild abdominal discomfort, but these symptoms tend to go away as your body adjusts to the medication. Uncomplicated muscle pain has been reported in approximately 1% to 5% of patients taking statins. The statins are associated with a risk of serious side effects, including liver disease and varying degrees of muscle pain and muscle weakness. Doctors routinely monitor liver function when a patient is prescribed a statin. According to the prescribing information, persistent increases of three times the upper limit of normal for liver enzyme tests occurred in 1% of patients taking Zocor during clinical studies of the drug. When treatment was stopped, the liver enzyme tests usually returned to pre-treatment levels.The effect of Zocor on liver enzymes does appear to be dose related, meaning that higher doses are more likely to cause an increase in liver enzyme levels. It is recommended that liver enzyme tests be performed before the start of treatment with Zocor and thereafter as needed. Patients receiving 80 mg per day should have another test 3 months after starting treatment with the 80 mg dose and periodically (twice per year) thereafter. Because of the potential for this side effect, Zocor should be used with caution in people who have a history of liver disease or who consume larger quantities of alcohol, another risk factor for liver disease. This is not a complete list of the side effects associated with Zocor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

Q: I have been on Zocor 40 mg for a few years. My total cholesterol last year was 99. Is that okay? My HDL was 42 and my LDL was good. What do you think?

A: Your question concerns the results of taking Zocor (Simvacor) //, as reflected in your total cholesterol and HDL levels (// I think your results are excellent! Keep up the good work with your cholesterol management in your diet, exercise and lifestyle choices. It is obvious you much be working with your health care provider, because it is always a good idea to check with one's health care provider in matters like this. Please continue to consult your health care provider for guidance. Gregory Latham, RPh

Q: Can Zocor elevate triglyceride levels? I do know that it is meant to lower cholesterol levels but since I have been taking it my triglycerides continue to become more elevated with each blood test.

A: There have been isolated cases where Zocor has increased triglycerides levels, however this is not typical. This should be addressed with your provider, as he or she may want to test you to make sure that Zocor (Simvacor) is not affecting your liver in a non-productive way. Please visit us here for more information on Zocor: // Matt Curley, Pharm D. MSCIS

2. Key facts

  • Simvacor seems to be a very safe medicine. It's unusual to have any side effects.
  • Keep taking Simvacor even if you feel well, as you will still be getting the benefits. Most people with high cholesterol don't have any symptoms.
  • Do not take Simvacor if you're pregnant, trying to get pregnant or breastfeeding.
  • Do not drink grapefruit juice while you're taking Simvacor. It doesn't mix well with this medicine.
  • Simvacor is also called Zocor and Simvador.

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