Simvacol tablets


  • Active Ingredient: Simvastatin
  • 40 mg, 20 mg, 10 mg
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What is Simvacol?

The active ingredient of Simvacol brand is simvastatin. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Simvastatin USP is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol. Simvastatin tablets USP for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of Simvastatin and the following inactive ingredients: ascorbic acid, butylated hydroxy anisole, citric acid anhydrous, hydroxypropyl cellulose, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinised starch, and titanium dioxide.

Used for

Simvacol is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Simvacol include: belching; loss of consciousness; troubled breathing with exertion; dry mouth; tightness in the chest; excess air or gas in the stomach or intestines; bloating; chills.

How to Buy Simvacol tablets online?

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Mixing Simvacol with herbal remedies and supplements

St John's wort, a herbal medicine taken for depression, reduces the amount of Simvacol in your blood, so it doesn't work as well.

Talk to your doctor if you're thinking about starting St John's wort, as it will change how well Simvacol works.

Are There Alternatives to Simvacol?

  • Increases the liver's ability to collect and get rid of LDL cholesterol ("bad cholesterol")
  • Increases HDL cholesterol ("good cholesterol")
  • Decreases triglycerides.

Strong CYP3A4 Inhibitors

These drugs block your body from breaking down Simvacol. This can lead to very high levels of the drug in your body. It can also increase side effects, including rhabdomyolysis.

These drugs should not be used with Simvacol. If treatment with these drugs is required, the use of Simvacol must be on hold during the course of treatment. Examples of these drugs include:

  • ketoconazole
  • itraconazole
  • voriconazole
  • posaconazole
  • erythromycin
  • clarithromycin
  • telithromycin
  • cyclosporine
  • danazol
  • nefazodone
  • boceprevir
  • telaprevir
  • ritonavir
  • tipranavir
  • indinavir
  • fosamprenavir
  • darunavir
  • atazanavir
  • nelfinavir
  • cobicistat

6. Pregnancy and breastfeeding

Simvacol is not recommended in pregnancy and while breastfeeding.

Talk to your doctor if you're planning to become pregnant. It's best to stop taking Simvacol at least 3 months before you start trying for a baby.

If you become pregnant while taking Simvacol, stop taking the medicine and tell your doctor.

home drugs a-z list Simvacol(Oral Suspension) side effects drug center

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Simvacol oral suspension is an HMG-CoA reductase inhibitor (statin) indicated as an adjunctive therapy to diet to: reduce the risk of total mortality by reducing CHD deaths and reduce the risk of non-fatal myocardial infarction, stroke, and the need for revascularization procedures in patients at high risk of coronary events; reduce elevated total-C, LDL-C, Apo B, TG and increase HDL-C in patients with primary hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia; reduce elevated TG in patients with hypertriglyceridemia and reduce TG and VLDL-C in patients with primary dysbetalipoproteinemia; reduce total-C and LDL-C in adult patients with homozygous familial hypercholesterolemia; and reduce elevated total-C, LDL-C, and Apo B in boys and postmenarchal girls, 10 to 17 years of age with heterozygous familial hypercholesterolemia after failing an adequate trial of diet therapy. Common side effects of Simvacol include

The dose range of Simvacol is 5 to 40 mg/day. Simvacol may interact with azole antifungals, macrolide antibiotics, HIV protease inhibitors, boceprevir, telaprevir, nefazodone, cobicistat-containing products, gemfibrozil, cyclosporine, danazol, verapamil, diltiazem, dronedarone, amiodarone, amlodipine, ranolazine, lomitapide, colchicine, niacin, and grapefruit juice. Tell your doctor all medications and supplements you use. Simvacol oral is not recommended for use during pregnancy; it may harm a fetus. Women taking Simvacol oral should discuss contraception with their doctor. It is unknown if Simvacol oral passes into breast milk. Because of the potential for undesirable side effects in a nursing infant, breastfeeding while taking Simvacol oral is not recommended.

Our Simvacol oral suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not exceed 10 mg Simvacol daily with:

(Note: These drugs are contraindicated with Simcor as Simcor is only available with 20 mg or 40 mg of Simvacol.)

Do not exceed 20 mg Simvacol daily with:

  • Amiodarone
  • Verapamil

Dosage for high cholesterol

Adult dosage (ages 18 years and older)

  • Typical starting dosage: Simvacol is often started at 10–20 mg per day. However, the dosage may range from 5 mg to 40 mg per day. You should take this drug once a day in the evening.
  • Dosage increases: Your doctor will gradually adjust your dosage if needed.

Child dosage (ages 10–17 years)

  • Typical starting dosage: 10 mg per day.
  • Note: Doses above 40 mg per day have not been studied in this age group.

Child dosage (ages 0–9 years)

This medication has not been studied in children below age 10 years.

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