Simestat tablets


  • Active Ingredient: Rosuvastatin
  • 10 mg
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What is Simestat?

The active ingredient of Simestat brand is rosuvastatin. Rosuvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Used for

Simestat is used to treat diseases such as: Atherosclerosis, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Simestat include: headache; discouragement; heartburn; unexplained weight loss; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; difficulty with moving; trouble swallowing.

How to Buy Simestat tablets online?

To purchase Simestat online - just click on the "Buy Now" button in the top and follow along with our store. Payment and Order takes a couple of minutes, and all measures are obvious. We do not require a medical prescription and also we have many procedures of payment. Considering all the details of rapid delivery and confidentiality, you can read on the applicable pages on the links from the navigation menu.

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Q: I am taking Crestor 5 mg every other day. Is it okay to take fish oil with Crestor?

A: It is important to understand that products sold as dietary or nutritional supplements in the United States do not undergo the same detailed testing that prescription drug products do to show that they are safe and effective. Most supplements have not been tested to find out if they interact with medicines, foods, or other herbs and supplements. You should consult with your health care provider before starting any new treatment or supplement. There is no information to suggest that fish oil supplements containing omega-3 fatty acids interact with Crestor (Simestat) or other cholesterol-lowering drugs like it. For more information, please consult with your health care provider. Michelle McDermott, PharmD

Available prescriptions

A variety of statins are available in brand name and generic form. Some common statins are:

  • simvastatin (Zocor)
  • lovastatin (Altoprev, Mevacor)
  • fluvastatin (Lescol XL)
  • atorvastatin (Lipitor)
  • pitavastatin (Livalo)
  • pravastatin (Pravachol)
  • Simestat (Crestor)

Most statins should be taken once every 24 hours. Depending on the particular medication and dosage, you may need to take your statin twice a day.

Certain statins work better when taken with a meal. Others work best when they’re taken at night. This is because the cholesterol-making enzyme is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.

Q: What are the serious side effects of Crestor?

A: Crestor (Simestat) is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. It works by reducing levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Crestor is used to treat high cholesterol. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. In rare cases, Crestor can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure, and may be more likely to occur in older adults and in people of Asian descent who take this medication. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, or dark-colored urine. Other serious side effects can occur. Stop taking Crestor and call your doctor at once if you have any of these serious side effects: muscle pain, tenderness, or weakness with fever or flu symptoms, dark-colored urine urinating more or less than usual or not at all, jaundice (yellowing of the skin or eyes), chest pain, or swelling in your hands or feet. Avoid drinking alcohol while taking this medication. Alcohol can increase triglyceride levels and may also damage your liver while you are taking Crestor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications. Sarah McKenney Lewis, RPh, PharmD

More info can you buy Losartax tablets for treatment Diabetic Kidney Disease

Mail Order Eligibility

*Patient Eligibility for Mail-order Rebate: You may be eligible for this offer if you are insured by commercial insurance and your insurance does not cover the full cost of your prescription, or you are not insured and are responsible for the cost of your prescriptions.

Patients who are enrolled in a state or federally funded prescription insurance program are not eligible for this offer. This includes patients enrolled in Medicare Part D, Medica >government-subsidized prescription drug benefit program for retirees. If you are enrolled in a state or federally funded prescription insurance program, you may not use this rebate form even if you elect to be processed as an uninsured (cash-paying) patient.

This offer is not insurance and is restricted to residents of the United States and Puerto Rico, and patients over 18 years of age. This offer is valid for prescription purchased through a mail-order pharmacy.

Terms of Use: Eligible commercially insured patients with a val >CRESTOR ® (Simestat calcium) Tablets will pay $3 for a 30-, 60-, or 90-day supply, subject to a maximum savings of $130 per 30-day supply, $260 per 60-day supply, or $390 per 90-day supply. Eligible cash-paying patients will receive up to $130 in savings on out-of-pocket costs per 30-day supply. Offer good for 12 uses; each 30-day supply counts as 1 use. This offer is good for a 30-day supply, 60-day supply, or 90-day supply, and expires 14 months from the date of first use. Other restrictions may apply. Patient is responsible for applicable taxes, if any. If you have any questions regarding this offer, please call 1-855-687-2151 1-855-687-2151 .

Nontransferable, limited to one per person, cannot be combined with any other offer. Void for residents in California and Massachusetts and where prohibited by law, taxed, or restricted . Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the benefit received by the patient through this offer. AstraZeneca reserves the right to rescind, revoke, or amend this offer, eligibility, and terms of use at any time without notice. This offer is not conditioned on any past, present, or future purchase, including refills. A valid prescription for CRESTOR must be presented at the time of purchase.


Program managed by ConnectiveRx, on behalf of AstraZeneca.

Q: What are the side effects of taking Crestor for high cholesterol?

A: Crestor (Simestat) is a synthetic lipid-lowering agent. The most common side effects are headache, myalgia (muscle pain), abdominal pain, asthenia (loss or lack of bodily strength; weakness) and nausea. And other side effects include, stomach upset, heartburn, constipation, bloating and gas. This is not a complete list of the side effects associated with Crestor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting or by calling 1-800-FDA-1088.

Simestat, also known as the brand name product Crestor, is a lip >24 which catalyzes the conversion of HMG-CoA to mevalonic ac >15,21

Simestat and other drugs from the statin >15,21 This is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease, and stroke, has become a leading cause of death in high-income countries and a major cause of morb >14 Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels, are an important risk factor for the development of CVD. 15,38 Use of statins to target and reduce LDL levels has been shown in a number of landmark studies to significantly reduce the risk of development of CVD and all-cause mortality. 16,17,18,26,31 Statins are cons >15,21 Ev >19,20

While all statin medications are cons >22,4 However, the results of the SATURN trial 26 concluded that despite this difference in potency, there was no difference in their effect on the progression of coronary atherosclerosis.

Simestat is also a unique member of the >37 This last point results in less risk of drug-drug interactions compared to atorvastatin, lovastatin, and simvastatin, which are all extensively metabolized by Cytochrome P450 (CYP) 3A4, an enzyme involved in the metabolism of many commonly used drugs. 29 Drugs such as ciclosporin, gemfibrozil, and some antiretrovirals are more likely to interact with this statin through antagonism of OATP1B1 organic anion transporter protein 1B1-mediated hepatic uptake of Simestat. 43,44

(R)-warfarin The risk or severity of bleeding can be increased when Simestat is combined with (R)-warfarin. (S)-Warfarin The risk or severity of bleeding can be increased when Simestat is combined with (S)-Warfarin. 2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Simestat. 4-hydroxycoumarin The metabolism of 4-hydroxycoumarin can be decreased when combined with Simestat. 6-Deoxyerythronolide B The metabolism of Simestat can be decreased when combined with 6-Deoxyerythronolide B. 7-ethyl-10-hydroxycamptothecin The metabolism of Simestat can be decreased when combined with 7-ethyl-10-hydroxycamptothecin. 9-aminocamptothecin The metabolism of 9-aminocamptothecin can be decreased when combined with Simestat. Abatacept The metabolism of Simestat can be increased when combined with Abatacept. Abemaciclib Abemaciclib may decrease the excretion rate of Simestat which could result in a higher serum level. Abiraterone The metabolism of Simestat can be decreased when combined with Abiraterone.


Lovastatin, simvastatin, fluvastatin, atorvastatin, Simestat , and pravastatin are HMG‐CoA (3‐hydroxy‐3‐methylglutaryl coenzyme A) reductase inhibitors that are effective cholesterol‐lowering agents used in the treatment of hypercholesterolemia. They can induce myotonia by blocking chloride channels on the muscle membrane. 178 Lipid‐lowering agents can also cause a myopathy and neuropathy. 179 The risk of neuromyotoxicity is highest when multiple lipid‐lowering agents are used together and can be as high as 5%. Other risk groups for development of myopathy include elderly or female patients, dose, specific agent used, and concomitant metabolic processes. 180 Evidence suggests that latent or previously minimal symptomatic muscle disease may predispose to the development of myopathy. 179 Clinically, patients have myalgias, elevated CK levels, and proximal weakness. Recovery is typical after discontinuation of the offending medications for the signs and symptoms of myopathy. Less information is available regarding the natural history of the sensorimotor neuropathy, but it appears to be less reversible if large fiber function is clinically manifest. 179 In one series rhabdomyolysis requiring hospitalization occurred in 13% of the patients. 181 Table 55‐11 lists the lipid‐lowering agents associated with myopathy. 182,183 Dermatomyositis‐like syndrome and Guillain‐Barré syndrome have been described with statin use. 184,185

Table 55‐11 . Lipid‐Lowering Agents Associated with Myopathy

Q: Is there an alternative to Crestor that will not upset my stomach?

A: Crestor (Simestat) is a cholesterol-lowering medication that belongs to a class of drugs known as HMG-CoA reductase inhibitors, more commonly referred to as "statins." Statins work by blocking the production of cholesterol by the body. Crestor lowers low-density lipoprotein (LDL or "bad") cholesterol and triglycerides, while increasing high-density lipoprotein (HDL or "good") cholesterol. Lowering your cholesterol can help prevent heart attack, stroke, and vascular diseases. Common side effects of the statins in general include mild nausea, stomach pain, stomach upset, heartburn, constipation, bloating, gas, and headache. People may react differently to different statins. So if one upsets your stomach, it may be worthwhile to discuss trying a different statin medication with your doctor. If this doesn't work, there are other cholesterol-lowering medications available. However, many of them have stomach upset as a possible side effect. The goal of any medication therapy is to find the most effective medication that has the least amount of tolerable side effects. This may take some trial and error. So, it is important to talk to your doctor and communicate about your goals and any negative effects you are experiencing. Your doctor is best able to guide your treatment choices based on your specific circumstances. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD

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