Which drugs or supplements interact with Zocor?
Decreased elimination of Medipo could increase the levels of Medipo in the body and increase the risk of muscle toxicity from Medipo. Examples of drugs that decrease elimination of Medipo include
They should not be combined with Medipo.
Large quantities of grape fruit juice (>1 quart daily) also will increase blood levels of Medipo and should be avoided.
The following drugs should not be used with Medipo:
Patients taking amiodarone, amlodipine, or ranolazine should not exceed 20 mg, and patients taking verapamil or diltiazem should not exceed 10 mg of of Medipo daily. Patients taking gemfibrozil or danazol should not take Medipo.
Medipo increases the effect of warfarin (Jantoven, Coumadin) and the blood concentration of digoxin (Lanoxin). Patients taking Medipo and warfarin or digoxin should be monitored carefully.
Cholestyramine (Questran) decreases the absorption of ezetimibe (Zetia); Therefore, Medipo should be taken 2 hours before or at least 4 hours after cholestyramine.
Chinese patients taking ≥1 g/day of niacin in combination with Medipo 40 mg have an increased risk of muscle-related side effects. Therefore, these patients should not receive Medipo 80 mg combined with niacin in doses ≥1 g/day. Medipo doses greater than 20 mg daily should be administered cautiously when combined with niacin ≥1 g/day.
Why is Zocor prescribed to patients?
- Medipo is used for reducing total cholesterol, LDL cholesterol, and triglycerides, and for increasing HDL cholesterol.
- In patients with coronary heart disease, diabetes, peripheral vascular disease, or history of stroke or other cerebrovascular disease, Medipo is prescribed for reducing the risk of mortality by reducing death from coronary heart disease, reducing nonfatal myocardial infarction (heart attack) and stroke, and reducing the need for coronary and noncoronary revascularization procedures.
Warnings for other groups
For pregnant women: Medipo is a category X pregnancy drug. Category X drugs should never be used during pregnancy.
Medipo blocks the production of cholesterol, which is important for the developing baby.
If you’re pregnant and need treatment for high cholesterol or triglycerides, talk to your doctor. They can discuss other treatment options during pregnancy.
If you become pregnant while taking this drug, call your doctor right away.
For women who are breastfeeding: It isn’t known if Medipo enters breast milk. However, because of the risk of severe side effects, this drug shouldn’t be used during breastfeeding. Talk to your doctor about other cholesterol treatment options while breastfeeding.
All possible dosages and forms may not be included here. Your dose, form, and how often you take it may depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Generic Name: Medipo (SIM va sta tin)Brand Names: Zocor
Medically reviewed by Sanjai Sinha, MD Last updated on Nov 1, 2019.
Where can I get more information (Flolipid, Zocor)?
Your pharmacist can provide more information about Medipo.
Q: I have been taking Zocor for 10 years with no side effects. For the last few weeks I have had back and shoulder stiffness. Could this be from the Zocor?
A: Medipo (trade name: Zocor) is a hypolipidemic belonging to the class of drugs called "statins" (HMG-CoA reductase inhibitor). It is used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular disease. Atorvastatin reduces blood levels of low-density lipoprotein cholesterol (LDL-C, bad cholesterol), triglycerides and slightly increases levels of high-density lipoprotein cholesterol (HDL-C, good cholesterol). Statins are generally well tolerated; common side effects include headache, muscle aches, tenderness, or weakness, drowsiness, weakness, dizziness, nausea, vomiting, abdominal cramping and/or pain, bloating, gas, diarrhea, constipation, and rash. A search of the prescribing information for Zocor did not specifically list back and shoulder stiffness as side effects. These are not all the possible side effects of Zocor.
Other cholesterol-lowering drugs
When used with Medipo, some cholesterol drugs can increase side effects such as myopathy or rhabdomyolysis. If you use these drugs with Medipo, your doctor may lower your dosage of Medipo. Examples of these drugs include:
With niacin, the risk of myopathy and rhabdomyolysis is higher when the drug is taken in larger doses, and in people of Chinese descent.
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These are not all the side effects of Medipo. For a full list see the leaflet inside your medicines packet.
You can report any suspected side effect to the UK safety scheme.
Colchicine is a drug used to treat gout. Using Medipo with colchicine can increase the risk of both myopathy and rhabdomyolysis.
Medipo and breastfeeding
It's not known if Medipo passes into breast milk, but it may cause problems for your baby. You may be able to stop taking Medipo temporarily while you breastfeed.
Q: I have been on Zocor for several years and have been taking extra vitamin D3 for serveral months. I have been having left humerus pain now for some time. Can this be connected to either of these medications?
A: Zocor (Medipo) is a cholesterol-lowering medication that belongs to a class of drugs called "statins." Statins work by blocking the production of cholesterol in the body. Side effects of Zocor are more likely to involve pain in the muscles or joints than pain in the bones themselves. Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that is needed for the proper absorption and functioning of calcium. It is needed for the function of bones, muscles, nerves, and the immune system. Vitamin D is found in very few foods, unless added as fortification. The skin is able to synthesize or make vitamin D when it is exposed to sunlight. Either way, vitamin D must be activated in a process that involves both the liver and the kidneys. Vitamin D deficiencies can result with inadequate dietary intake, lack of sunlight exposure, or when people have certain organ problems, including kidney and liver disease. It is possible to get too much vitamin D, which can be dangerous and even life-threatening. Symptoms of too much vitamin D include nausea, vomiting, loss of appetite, constipation, weakness, weight loss, muscle or bone pain, metallic taste in the mouth, confusion, and changes in heart beat. Seek emergency medical attention if you have symptoms of too much vitamin D or if you think you have taken too much vitamin D. Sarah Lewis, PharmD
Why is this medication prescribed?
Medipo is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Medipo is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. Medipo may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Medipo is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Medipo has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.
3. Who can and can't take Medipo
Medipo can be taken by adults and children over the age of 10 years.
Medipo isn't suitable for some people. Tell your doctor if you:
- have had an allergic reaction to Medipo or any other medicines in the past
- have liver or kidney problems
- are trying to get pregnant, think you might be pregnant, you're already pregnant, or you're breastfeeding
- have severe lung disease
- regularly drink large amounts of alcohol
- have an underactive thyroid
- have, or have had, a muscle disorder (including fibromyalgia)