No, it belongs to the drug class fibric acid derivatives.
"Fibric acid derivatives or fibrates are regarded as broad-spectrum lipid lowering drugs. Their main action is to decrease triglyceride levels but they also tend to reduce low density lipoprotein (LDL) cholesterol levels and help to raise high density lipoprotein (HDL) cholesterol. Fibrates appear to activate a protein called peroxisome proliferator-activated receptor alpha (PPAR-alpha). PPAR-alpha activates the enzyme lipoprotein lipase and ultimately results in decreased formation of very low-density lipoprotein (VLDL) cholesterol (which is converted into LDL cholesterol) and triglycerides and an increase in HDL cholesterol."
Lofat is often used along with other cholesterol drugs, such as statins.
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Lofat is a prescription drug. It comes in two forms: oral tablet and oral capsule.
The oral tablet is available as the brand-name drugs Fenoglide, Tricor, and Triglide. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.
Lofat may be used as part of a combination therapy. This means you may need to take it with other cholesterol drugs, such as statins.
What is this drug used for?
It is used to lower triglycerides.It is used to lower bad cholesterol and raise good cholesterol (HDL).
Pharmacy Lofat 145mg Tablet
What Is Lofat and How Does It Work?
Lofat is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood. Lofat belongs to a group of drugs known as "fibrates." Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis). However, Lofat might not lower your risk of a heart attack or stroke. Talk to your doctor about the risks and benefits of Lofat.
In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help Lofat work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.
Lofat is available under the following different brand names: Tricor, Lofibra tablets, Fenoglide, Lipofen, and Triglide.
Dosages of Lofat:
Dosage Forms and Strengths
Dosage Considerations – Should be Given as Follows:
Pediatric: Safety and efficacy not established
- Hypercholesterolemia, mixed dyslipidemia: Initially, 145 mg orally once/day
- Hypertriglyceridemia: Initially, 48-145 mg orally once/day
- Titrate every 4-8 weeks up to no more than 145 mg orally once/day
- Geriatric, initial: 48 mg/day; evaluate before increase dose
- Hypercholesterolemia, Mixed Dyslipidemia: initial 160 mg orally once/day
- Hypertriglyceridemia: 50-160 mg orally once/day initially
- Geriatric, initial: 50 mg/day
- Hypercholesterolemia, Mixed Dyslipidemia: initial 150 mg orally once/day
- Hypertriglyceridemia: initial 50-150 mg orally once/day
- Geriatric, initial: No more than 50 mg/day
- Hypercholesterolemia, Mixed Dyslipidemia: 160 mg orally once/day
- Hypertriglyceridemia: 54-160 mg orally once/day
- Geriatric, initial: 54 mg/day
- Hypercholesterolemia, Mixed Dyslipidemia: 120 mg orally once/day
- Hypertriglyceridemia: 40-120 mg orally once/day
- Geriatric, initial: 40 mg/day
- Symptoms include GI distress
- Treatment is supportive
Renal impairment (CrCl less than 50 mL/min):
- TriCor: Initial, 48 mg/day initially; evaluate before increase dose
- Triglide: Initial, 50 mg/day
- Lipofen: Initial, no more than 50 mg/day
- Lofibra tablets: Initial, 54 mg/day
- Fenoglide: Initial, 40 mg/day
- TriCor, Triglide, and Lofibra tablets can be taken without regard to meals
- Lipofen: Take with meals
Severe allergic reaction warning
Lofat can cause severe allergic reactions. These can include anaphylaxis and angioedema (swelling), and can be life-threatening. Some reactions can occur days or weeks after starting this drug. These include Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS).
Symptoms of a severe reaction can include:
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Lofat is a prodrug, which means that it must be converted to another chemical (fenofibric acid) in the body before it can work.
Fenofibric acid increases the activity of lipoprotein lipase, an enzyme that breaks down triglycerides, a type of fat in the blood. It also affects production, transportation, and storage of triglycerides. Overall benefits of Lofat use include a 30%-60% decrease in total blood triglycerides, a modest increase in high density lipoprotein cholesterol (HDL-C, commonly known as "good" cholesterol), and a decrease in low density lipoprotein cholesterol (LDL-C, commonly known as "bad" cholesterol) and total cholesterol.
Lofat products are available in multiple strengths and dosage forms. Lofat formulations are not bioequivalent and are not interchangeable except for generic equivalents.
Warnings for other groups
For pregnant women: There haven’t been enough studies done in humans to show if Lofat poses a risk to a human fetus. Research in animals has shown a risk to the fetus when the mother takes the drug. However, animal studies don’t always predict the way humans would respond.
Talk with your doctor if you’re pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk.
If you become pregnant while taking this drug, call your doctor right away.
For women who are breastfeeding: Lofat may pass into breast milk and cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
Lofat oral tablet is used for long-term treatment. It comes with risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: Your cholesterol levels may not be controlled. This raises your risk of serious health problems such as heart disease, heart attack, or stroke.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
- back pain
- muscle pain
- common cold
- upper respiratory tract infection
If you think you’ve taken too much of the drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: Your cholesterol levels should improve. You won’t feel Lofat working, but your doctor will check your cholesterol levels using blood tests. Your doctor may adjust your dosage based on the results of these tests.
Keep these considerations in mind if your doctor prescribes Lofat for you.