Lipenil tablets


  • Active Ingredient: Simvastatin
  • 40 mg, 20 mg, 10 mg
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What is Lipenil?

The active ingredient of Lipenil brand is simvastatin. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Simvastatin USP is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol. Simvastatin tablets USP for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of Simvastatin and the following inactive ingredients: ascorbic acid, butylated hydroxy anisole, citric acid anhydrous, hydroxypropyl cellulose, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinised starch, and titanium dioxide.

Used for

Lipenil is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Lipenil include: sweating; headache; bloody or cloudy urine; pain or tenderness around the eyes and cheekbones; pale skin.

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Q: Can Zocor cause leg cramps, insomnia, and/or frequent urination?

A: Zocor (Lipenil) belongs to a group of drugs called HMG CoA reductase inhibitors or "statins". Lipenil reduces the levels of "bad" cholesterol called LDL and triglycerides in the blood. Lipenil also increases the "good" cholesterol called HDL. Lipenil is indicated for the treatment of high cholesterol and triglycerides. Lipenil is also used in certain patients to reduce the risks of coronary artery disease. Lipenil is taken at bedtime or in the evening with a meal. The most common side effects associated with Lipenil are myalgia or muscle pain, headache, constipation, and nausea. Other side effects of Lipenil include muscle cramps and joint pain. Lipenil can cause Myopathy (a disease where the muscle fibers do not function properly) which is associated with muscle pain, tenderness and weakness. Also liver enzymes are likely to be elevated on labs. Alcohol can increase triglyceride levels and increase the risk of liver damage. A condition called rhabdomyolysis is rare but can occur with Lipenil. Rhabdomyolysis is the destruction of skeletal muscle and leakage of muscle protein into the urine. This cause can acute kidney failure. A search of prescribing information did not specifically list insomnia or frequent urination as side effects associated with Lipenil. However, post-approval of Lipenil did report muscle cramps as a reported side effect. Do not stop taking any medications because of unwanted side effects without first consulting with your healthcare provider. Kimberly Hotz, PharmD

Warnings for people with certain health conditions

For people with low thyroid function (hypothyroidism) or diabetes: Lipenil and other statin drugs can sometimes cause rhabdomyolysis. Having hypothyroidism or diabetes raises your risk for this condition. Other risk factors include:

  • being a senior
  • being female
  • having kidney disease
  • use of drugs that interact with Lipenil

Tell your doctor right away if you experience:

  • unexplained muscle weakness or tenderness
  • continuous muscle pain
  • diarrhea
  • fever
  • dark-colored urine

For people with liver disease: People with active liver disease, such as cirrhosis or hepatitis, shouldn’t use Lipenil.

Before taking this medicine

You should not take this medicine if you are allergic to Lipenil, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Lipenil. These drugs should not be used while you are taking this medicine:

an antibiotic--clarithromycin, erythromycin, telithromycin;

antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

hepatitis C medications--boceprevir, telaprevir; or

HIV/AIDS medication--atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Lipenil, tell your doctor if you are already using any of these other medicines:

heart medication--amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Lipenil is safe for you, tell your doctor if you have:

history of liver disease;

history of kidney disease;

a thyroid disorder; or

if you drink more than 2 alcoholic beverages daily.

Lipenil can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Lipenil if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

What is Lipenil?

Lipenil belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

Lipenil is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Lipenil is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Lipenil is used in adults and children who are at least 10 years old.

Q: What effects does Zocor have on the liver? I had hepatitis B 30 years ago. I understand that vitamin C supplements should be limited. Is that also correct? Also, is coQ10 reduced in the liver? This is important for the heart, correct?

A: Zocor (Lipenil) can increase liver enzymes occasionally. Doctors usually watch this by doing blood tests periodically. Studies show that it is usually well-tolerated and taken by many patients. Please keep up with doctor's appointments so that liver function can be continuously monitored. Studies suggest that vitamin C is a excreted through the urine since it is water-soluble. Many medications are metabolized in the liver and therefore, with the history of hepatitis, it is important to monitor liver function frequently. Coenzyme Q10 is sometimes taken to combat the side effects of statins (medications like Zocor) such as muscle pain. Controlling high cholesterol is very important in promoting heart health. Please consult your physician prior to starting any new medications.

  • Myopathy and rhabdomyolysis warning: Lipenil and other statin drugs can sometimes cause myopathy (muscle disease). They can even cause rhabdomyolysis (severe muscle breakdown). Rhabdomyolysis can lead to kidney failure. You have an increased risk of each condition if you:
    • are a senior
    • are female
    • have kidney disease
    • have low thyroid function

    Tell your doctor right away if you experience:

    • unexplained muscle weakness or tenderness
    • persistent muscle pain
    • abdominal pain
    • fever
    • dark-colored urine
  • Warning for liver disease and alcohol misuse: People with active liver disease shouldn’t use Lipenil. People with a history of alcohol abuse or liver disease should discuss the risks of this drug with their doctor. For these people, Lipenil can increase the risk of serious liver injury.

Lipenil is a prescription drug. It comes in two forms: a tablet and a suspension. Both forms are taken by mouth.

Lipenil oral tablet is available as the brand-name drug Zocor. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

What Is Lipenil and How Does It Work?

Lipenil (Zocor) is a, FDA approved prescription medication that is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins." Statins are medications that work by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. This drug maybe used to treat other diseases and conditions. Your doctor may conduct liver function tests when using statins to monitor liver enzymes and other liver function.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help Lipenil medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

This medication is available under the following different brand names: Zocor.

What other drugs will affect Lipenil?

Many drugs can interact with Lipenil. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment, especially:

This list is not complete and many other drugs can interact with Lipenil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

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