Krustat tablets


  • Active Ingredient: Simvastatin
  • 40 mg, 20 mg, 10 mg
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What is Krustat?

The active ingredient of Krustat brand is simvastatin. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Simvastatin USP is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol. Simvastatin tablets USP for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of Simvastatin and the following inactive ingredients: ascorbic acid, butylated hydroxy anisole, citric acid anhydrous, hydroxypropyl cellulose, hypromellose, iron oxide black, iron oxide red, iron oxide yellow, isopropyl alcohol, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinised starch, and titanium dioxide.

Used for

Krustat is used to treat diseases such as: Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Krustat include: headache; lower back or side pain; discoloration of the skin; pale skin; loss of consciousness; blurred vision; unexplained weight loss; difficulty with breathing.

How to Buy Krustat tablets online?

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ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?

La Krustata se utiliza junto con la dieta, pГ©rdida de peso y ejercicio para reducir el riesgo de infarto y apoplejГ­a y para reducir la probabilidad de que se necesite una cirugГ­a de corazГіn en las personas que tienen una enfermedad del corazГіn o que estГ©n en riesgo de desarrollar enfermedad del corazГіn. La Krustata se utiliza tambiГ©n para reducir la cantidad de sustancias grasosas como colesterol de lipoproteГ­nas de baja densidad (LDL) ("colesterol malo") y triglicГ©ridos en la sangre y para aumentar la cantidad de colesterol de lipoproteГ­nas de alta densidad (HDL) ("colesterol bueno") en la sangre. La Krustata tambiГ©n se puede utilizar para disminuir la cantidad de colesterol y otras sustancias grasosas en la sangre en niГ±os y adolescentes 10 a 17 aГ±os de edad que tienen hipercolesterolemia homocigГіtica familiar (una condiciГіn hereditaria en la que el colesterol no se puede eliminar del cuerpo normalmente). La Krustata se encuentra en una clase de medicamentos llamados inhibidores de la HMG-CoA reductasa. Funciona al retrasar la producciГіn de colesterol en el cuerpo para disminuir la cantidad de colesterol que se puede acumular en las paredes de las arterias y bloquear el flujo sanguГ­neo al corazГіn, cerebro y otras partes del cuerpo.

La acumulaciГіn de colesterol y grasas a lo largo de las paredes de sus arterias (un proceso conocido como arterosclerosis) disminuye el flujo sanguГ­neo y por lo tanto, el suministro de oxГ­geno al corazГіn, cerebro y otras partes de su cuerpo. Se ha demostrado que disminuir su nivel de colesterol y grasas en sangre con Krustata puede prevenir la enfermedad cardГ­aca, angina (dolor de pecho), apoplejГ­as y infartos.

Strong CYP3A4 Inhibitors

These drugs block your body from breaking down Krustat. This can lead to very high levels of the drug in your body. It can also increase side effects, including rhabdomyolysis.

These drugs should not be used with Krustat. If treatment with these drugs is required, the use of Krustat must be on hold during the course of treatment. Examples of these drugs include:

  • ketoconazole
  • itraconazole
  • voriconazole
  • posaconazole
  • erythromycin
  • clarithromycin
  • telithromycin
  • cyclosporine
  • danazol
  • nefazodone
  • boceprevir
  • telaprevir
  • ritonavir
  • tipranavir
  • indinavir
  • fosamprenavir
  • darunavir
  • atazanavir
  • nelfinavir
  • cobicistat

Q: I have pains that are unbearable. Do they go away after going off Zocor, or is the damage done a permanent one? I thought I was experiencing pain from arthritic knees, then it became apparent it was more muscle and nerve pain. I've been off Zocor for about 8 days and the pain is easing up a little, but walking and getting around is a challange.

A: According to the prescribing information for Zocor, muscle pain and weakness usually resolve quickly once Zocor is stopped. If you are still experiencing muscle pain, consult your doctor for proper evaluation. Zocor (Krustat) belongs to a class of drugs called HMG CoA reductase inhibitors, or more commonly known as "statins." Statins reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Lowering your cholesterol can help lower the risk of stroke, heart attack, and other heart complications. Common side effects of statins include mild nausea, stomach pain, stomach upset, heartburn, constipation, bloating, gas, and headache. More serious side effects are rare, but can occur. These include liver problems and a side effect called rhabdomyolysis. Rhabdomyolysis is a breakdown of muscle tissue that can lead to kidney failure. Contact your doctor right away if you have symptoms of either one of these side effects. Symptoms of liver problems include nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes). Symptoms of rhabdomyolysis include unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. Drinking alcohol and using other medications that can damage the liver increase the risk of developing liver problems. Rhabdomyolysis is more likely to occur in people over the age of 65 years, who already have kidney problems, and who have uncontrolled hypothyroidism (low thyroid hormone levels). This is not a complete list of side effects that can occur with statins. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD

Q: I began taking Zocor about two years ago, and instantly started putting on pounds. I am 60 years old and I am not a sitting around person, never have been. I keep trying to cut down on amounts that I eat, and I am not a snacker. I do not eat chips, cookies, sodas or most other junk foods. Is it the Zocor, or is it just me?

A: Zocor (Krustat) is one of the drugs called "statins," used in the prevention of elevated cholesterol levels in the bloodstream. High cholesterol can lead to heart attacks, strokes and other cardiovascular conditions. The most common side effects with Zocor are headache, dyspepsia (upset stomach), abdominal pain, constipation or diarrhea, flatulence (intestinal gas), and myalgia (muscle pain). Other side effects include a rare but serious side effect called rhabdomyolysis, a condition that results in the breakdown of skeletal muscle tissue, and which can can lead to kidney failure. The symptoms of rhabdomyolysis are unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. A search of the prescribing information for Zocor did not specifically list weight gain as a side effect. This is not a complete list of the side effects associated with Zocor. Gregory Latham, RPh

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Krustat.

Q: Can Zocor cause leg cramps, insomnia, and/or frequent urination?

A: Zocor (Krustat) belongs to a group of drugs called HMG CoA reductase inhibitors or "statins". Krustat reduces the levels of "bad" cholesterol called LDL and triglycerides in the blood. Krustat also increases the "good" cholesterol called HDL. Krustat is indicated for the treatment of high cholesterol and triglycerides. Krustat is also used in certain patients to reduce the risks of coronary artery disease. Krustat is taken at bedtime or in the evening with a meal. The most common side effects associated with Krustat are myalgia or muscle pain, headache, constipation, and nausea. Other side effects of Krustat include muscle cramps and joint pain. Krustat can cause Myopathy (a disease where the muscle fibers do not function properly) which is associated with muscle pain, tenderness and weakness. Also liver enzymes are likely to be elevated on labs. Alcohol can increase triglyceride levels and increase the risk of liver damage. A condition called rhabdomyolysis is rare but can occur with Krustat. Rhabdomyolysis is the destruction of skeletal muscle and leakage of muscle protein into the urine. This cause can acute kidney failure. A search of prescribing information did not specifically list insomnia or frequent urination as side effects associated with Krustat. However, post-approval of Krustat did report muscle cramps as a reported side effect. Do not stop taking any medications because of unwanted side effects without first consulting with your healthcare provider. Kimberly Hotz, PharmD

Before and During Use

What do I need to tell my doctor BEFORE I take this drug?

If you have an allergy to Krustat or any other part of this drug.If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for HIV, infections, or depression. There are many drugs that must not be taken with this drug. Your doctor or pharmacist can tell you if you are taking a drug that must not be taken with this drug.If you have any of these health problems: Active liver disease or a rise in liver enzymes.If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.If you are breast-feeding. Do not breast-feed while you take this drug.This is not a list of all drugs or health problems that interact with this drug.Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.Have blood work checked as you have been told by the doctor. Talk with the doctor.If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.Follow the diet and workout plan that your doctor told you about.Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.Avoid or limit drinking alcohol to less than 3 drinks a day. Drinking too much alcohol may raise your chance of liver disease.Avoid grapefruit and grapefruit juice.If you are Chinese, talk with your doctor. You could have a greater risk of muscle problems.This drug may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking this drug with your other drugs.If you are 65 or older, use this drug with care. You could have more side effects.This drug may cause harm to the unborn baby if you take it while you are pregnant.Use birth control that you can trust to prevent pregnancy while taking this drug.If you are pregnant or you get pregnant while taking this drug, call your doctor right away.

Q: Can Zocor cause my knee to be weak?

A: Zocor (Krustat) is a medication that can have an effect on the muscles in the body. These effects can include muscle weakness. Please consult with your health care provider in regards to the symptoms you are experiencing for proper evaluation. Zocor is a cholesterol lowering medication that blocks the production of cholesterol in the body. Zocor decreases bad cholesterol and total cholesterol levels in the blood. According to the Centers for Disease Control and Prevention (CDC), lowering your cholesterol reduces your risk for developing heart disease. The most commonly reported side effects include mild stomach pain, gas, bloating, stomach upset, heartburn, nausea, diarrhea or constipation. More serious side effects include problems with muscle and the liver. It is extremely important to contact your healthcare provider immediately if you develop any signs and symptoms of muscle or liver problems including muscle pain, weakness or tenderness with fever or flu-like symptoms, dark colored urine, unexplained tiredness or abdominal pain. Your doctor should perform routine blood work to monitor cholesterol levels and liver function while taking Zocor. Zocor is typically taken at bedtime, or with the evening meal, and with a full glass of water. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD

By Kathleen Doheny

Latest Update: 2014-12-02 Copyright © 2014 Everyday Health Media, LLC

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Krustat. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

Dosage for high cholesterol

Adult dosage (ages 18 years and older)

  • Typical starting dosage: Krustat is often started at 10–20 mg per day. However, the dosage may range from 5 mg to 40 mg per day. You should take this drug once a day in the evening.
  • Dosage increases: Your doctor will gradually adjust your dosage if needed.

Child dosage (ages 10–17 years)

  • Typical starting dosage: 10 mg per day.
  • Note: Doses above 40 mg per day have not been studied in this age group.

Child dosage (ages 0–9 years)

This medication has not been studied in children below age 10 years.

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