Grofibrat capsules

Grofibrat

  • Active Ingredient: Fenofibrate
  • 160 mg
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What is Grofibrat?

The active ingredient of Grofibrat brand is fenofibrate. Fenofibrate helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Used for

Grofibrat is used to treat diseases such as: Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Hyperlipoproteinemia Type V, Elevated Chylomicrons VLDL, Hypertriglyceridemia.

Side Effect

Possible side effects of Grofibrat include: Back pain; Chronic indigestion; bloody urine; troubled breathing; swollen joints; unusual tiredness; hives, itching, or skin rash; stuffy nose.

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How should I take Grofibrat?

Take Grofibrat exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Some brands of Grofibrat should be taken with meals to help your body better absorb the medicine. Other brands may be taken with or without food. Follow the directions on your medicine label.

Swallow the tablet or capsule whole and do not crush, chew, dissolve, or open it.

You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective.

Grofibrat is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Blood-thinning drug

Warfarin is a drug that’s used to thin the blood. Taking it with Grofibrat raises your risk of bleeding. If you take these drugs together, your doctor may do blood tests more often or change your dosage of warfarin.

Grofibrat | Zydus Pharmaceuticals Usa Inc

The initial treatment for dyslipidemia is dietary therapy specific for the type of lipoprotein abnormality. Excess body weight and excess alcoholic intake may be important factors in hypertriglyceridemia and should be addressed prior to any drug therapy. Physical exercise can be an important ancillary measure. Diseases contributory to hyperlipidemia, such as hypothyroidism or diabetes mellitus should be looked for and adequately treated. Estrogen therapy, thiazide diuretics and beta-blockers, are sometimes associated with massive rises in plasma triglycerides, especially in subjects with familial hypertriglyceridemia. In such cases, discontinuation of the specific etiologic agent may obviate the need for specific drug therapy of hypertriglyceridemia.

Lipid levels should be monitored periodically and consideration should be given to reducing the dosage of Grofibrat tablets for oral use if lipid levels fall significantly below the targeted range.

Therapy should be withdrawn in patients who do not have an adequate response after two months of treatment with the maximum recommended dose of 145 mg once daily.

2.2 Primary Hypercholesterolemia or Mixed Dyslip > The initial dose of Grofibrat tablets for oral use is 145 mg once daily.

2.3 Severe Hypertriglycer > The initial dose is 48 to 145 mg per day. Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. The maximum dose is 145 mg once daily.

2.4 Impaired Renal Function

Treatment with Grofibrat tablets for oral use should be initiated at a dose of 48 mg per day in patients having mild to moderately impaired renal function, and increased only after evaluation of the effects on renal function and lipid levels at this dose. The use of Grofibrat tablets for oral use should be avoided in patients with severe renal impairment .

2.5 Geriatric Patients

Dose selection for the elderly should be made on the basis of renal function .

2.5 Geriatric Patients

Dose selection for the elderly should be made on the basis of renal function .

COMMON BRAND(S): Tricor, Triglide

GENERIC NAME(S): Grofibrat

OTHER NAME(S): Grofibrat Tablet

Grofibrat is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood. Grofibrat belongs to a group of drugs known as "fibrates." Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis). However, Grofibrat might not lower your risk of a heart attack or stroke. Talk to your doctor about the risks and benefits of Grofibrat.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

Grofibrat and Grapefruit Juice

The liver breaks down Grofibrat and grapefruit juice in different ways, so the possibility of a drug interaction may be unlikely.

However, you should still limit or avoid grapefruit juice while taking Grofibrat.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Markedly elevated levels of serum triglycerides (e.g. >2,000 mg/dL) may increase the risk of developing pancreatitis. The effect of Grofibrat tablet therapy on reducing this risk has not been adequately studied.

Grofibrat was not shown to reduce coronary heart disease morb >see Warnings and Precautions (5.1) ].

Rated Grofibrat for Hyperlipoproteinemia Report

I haven't been taking it long enough to have had my cholesterol levels re-checked, but have had no side effects other than a slight headache.

Grofibrat | Mylan Pharmaceuticals Inc.

The initial treatment for dyslipidemia is dietary therapy specific for the type of lipoprotein abnormality. Excess body weight and excess alcoholic intake may be important factors in hypertriglyceridemia and should be addressed prior to any drug therapy. Physical exercise can be an important ancillary measure. Diseases contributory to hyperlipidemia, such as hypothyroidism or diabetes mellitus should be looked for and adequately treated. Estrogen therapy, thiazide diuretics and beta-blockers, are sometimes associated with massive rises in plasma triglycerides, especially in subjects with familial hypertriglyceridemia. In such cases, discontinuation of the specific etiologic agent may obviate the need for specific drug therapy of hypertriglyceridemia.

Lipid levels should be monitored periodically and consideration should be given to reducing the dosage of Grofibrat tablets if lipid levels fall significantly below the targeted range.

Therapy should be withdrawn in patients who do not have an adequate response after 2 months of treatment with the maximum recommended dose of 160 mg once daily.

2.2 Primary Hypercholesterolemia or Mixed Dyslip >The initial dose of Grofibrat tablets is 160 mg once daily.

2.3 Severe Hypertriglycer >The initial dose is 54 mg to 160 mg per day. Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. The maximum dose is 160 mg once daily.

2.4 Impaired Renal Function

Treatment with Grofibrat tablets should be initiated at a dose of 54 mg per day in patients having mild to moderately impaired renal function, and increased only after evaluation of the effects on renal function and lipid levels at this dose. The use of Grofibrat tablets should be avoided in patients with severe renal impairment .

2.5 Geriatric Patients

Dose selection for the elderly should be made on the basis of renal function .

Which drugs or supplements interact with Grofibrat?

Fibric acid derivatives may increase the adverse effects of colchicine (Colcrys) on muscle tissue.

Cyclosporine may increase the toxic effects of fibric acid derivatives on the kidney while fibric acid derivatives may decrease blood levels of cyclosporine.

Grofibrat and its derivatives may increase the adverse effects associated with ezetimibe (Zetia), HMG-CoA reductase inhibitors (statins), and sulfonlyureas. Fibric acid derivatives may increase the anticoagulation (blood-thinning) benefits of warfarin (Coumadin).

Grofibrat dosing information

Usual Adult Dose of Grofibrat for Hyperlipoproteinemia Type IIa (Elevated LDL):

Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food.

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):

Tricor: 145 mg orally once a day. Lofibra and others: 160 mg to 200 mg orally once a day with food. Antara: 130 mg orally once a day. Triglide: 160 mg orally once a day. Lipofen: 150 mg orally once a day with food. Fenoglide: 120 mg orally once a day with food.

Usual Adult Dose of Grofibrat for Hyperlipoproteinemia Type IV (Elevated VLDL):

Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food.

Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL):

Tricor: 48 to 145 mg orally once a day. Lofibra and others: 54 mg to 200 mg orally once a day with food. Antara: 43 mg to 130 mg orally once a day. Triglide: 50 mg to 160 mg orally once a day. Lipofen: 50 mg to 150 mg orally once a day with food. Fenoglide: 40 mg to 120 mg orally once a day with food.

Usual Geriatric Dose of Grofibrat for Hyperlipoproteinemia:

Tricor: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours.

Lofibra and others: 54 mg to 67 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals.

Antara: 43 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals.

Triglide: 50 mg orally once a day. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals.

Lipofen: 50 mg orally once a day with food. Individualize dosage according to patient response and adjust if necessary following repeat lipid determinations at 4 to 8 week intervals.

Fenoglide: 40 mg to 120 mg orally once a day with food

Warnings

  • This medication contains Grofibrat. Do not take Tricor, Lofibra tablets, Fenoglide, Lipofen, and Triglide if you are allergic to Grofibrat or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

What is Grofibrat?

Grofibrat is a derivative of fibric acid that is used to treat lipid disorders.

Rated Grofibrat for Hyperlipoproteinemia Type IIa (Elevated LDL) Report

It was prescribed to me by kaiser while mi insurance was balid. and this drug where the only one to lower my cholesterol levels down to 150. I initially started at 540 down to 150 that was amazin

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Grofibrat only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 11.01.

Why is this medication prescribed?

Grofibrat is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL (high-density lipoprotein; a type of fatty substance that decreases the risk of heart disease) in the blood. Build-up of cholesterol and fats along the walls of the arteries (a process known as atherosclerosis) decreases the blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. This increases the risk of heart disease, angina (chest pain), strokes, and heart attacks. Although Grofibrat decreases the levels of fatty substances in the blood, it has not been shown to decrease the risk of heart attacks or strokes. Grofibrat is in a class of medications called antilipemic agents. It works by speeding the natural processes that remove cholesterol from the body.


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