Docfenofi capsules

Docfenofi

  • Active Ingredient: Fenofibrate
  • 160 mg
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What is Docfenofi?

The active ingredient of Docfenofi brand is fenofibrate. Fenofibrate helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Used for

Docfenofi is used to treat diseases such as: Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Hyperlipoproteinemia Type V, Elevated Chylomicrons VLDL, Hypertriglyceridemia.

Side Effect

Possible side effects of Docfenofi include: unusual bleeding or bruising; unusual tiredness; yellow eyes or skin; muscle aches and pains; Chills or fever; decreased frequency or amount of urine; bloating; sneezing.

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What is Docfenofi?

Docfenofi is a derivative of fibric acid that is used to treat lipid disorders.

Docfenofi and Grapefruit Juice

The liver breaks down Docfenofi and grapefruit juice in different ways, so the possibility of a drug interaction may be unlikely.

However, you should still limit or avoid grapefruit juice while taking Docfenofi.

Rated Docfenofi for Hyperlipoproteinemia Report

This medication made my muscles ache, my jaw hurt (my whole mouth hurt) and very tired. I would never recommend this drug to anyone. Side effects are the worst and it tore my muscles.

Info about how to order Cardiogoxin tablets for Atrial Fibrillation

What Is Docfenofi (Tricor)?

Docfenofi is the generic form of the brand name drug Tricor, used to treat high levels of cholesterol and triglyceride in your blood.

Docfenofi belongs to a class of medications known as antilipemics and fibric acid. It works by breaking down fats and helping the body eliminate triglycerides.

Tricor was originally approved by the Food and Drug Administration (FDA) in 2001 and is manufactured by Abbott Laboratories.

Drug forms and strengths

Generic: Docfenofi

  • Form: oral tablet
  • Strengths: 40 mg, 48 mg, 54 mg, 107 mg, 120 mg, 145 mg, 160 mg

Brand: Fenoglide

  • Form: oral tablet
  • Strengths: 40 mg, 120 mg

Brand: Tricor

  • Form: oral tablet
  • Strengths: 48 mg, 145 mg

Brand: Triglide

  • Form: oral tablet
  • Strength: 160 mg

Cautions

Cholelithiasis reported with use; discontinue if gallstones detected upon gallbladder studies

Rare myopathy, myositis, or rhabdomyolysis reported with use; monitor

Increase in hepatic transaminases reported; discontinue if enzyme levels persist 3 times above the upper limit of normal

Reversibly increases serum creatinine levels; consider monitoring renal function in patients at risk for renal impairment

Thrombocytopenia and agranulocytosis reported; monitor blood counts periodically during the first year of therapy

Associated with pulmonary embolism and deep venous thrombosis; use caution in patients with risk factors for VTE

Concomitant use with oral anticoagulants (monitor and adjust warfarin dose prn)

May further increase risk for rhabdomyolysis when added to optimal HMG-CoA reductase inhibitor regimen to further decrease TG and increase HDLs

Paradoxical decreases in HDL cholesterol (HDL-C) level reported

Rule out secondary causes of hyperlipidemia before initiating therapy

Withdraw therapy if no adequate response seen after 2-3 months

Use with caution in the elderly; dose adjustments may be necessary

Docfenofi increases cholesterol excretion into bile, leading to risk of cholelithiasis; perform gallbladder studies if cholelithiasis suspected

Fibric acid derivatives as monotherapy or in combination with simvastatin have not been shown to significantly reduce cardiovascular mortality in major clinical studies

Which drugs or supplements interact with Docfenofi?

Fibric acid derivatives may increase the adverse effects of colchicine (Colcrys) on muscle tissue.

Cyclosporine may increase the toxic effects of fibric acid derivatives on the kidney while fibric acid derivatives may decrease blood levels of cyclosporine.

Docfenofi and its derivatives may increase the adverse effects associated with ezetimibe (Zetia), HMG-CoA reductase inhibitors (statins), and sulfonlyureas. Fibric acid derivatives may increase the anticoagulation (blood-thinning) benefits of warfarin (Coumadin).

More common side effects

The more common side effects that can occur with use of Docfenofi include:

  • headache
  • back pain
  • nausea
  • indigestion
  • stuffy or runny nose

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Cholesterol drugs

Taking Docfenofi with certain cholesterol drugs called bile acid sequestrants may make it harder for your body to absorb Docfenofi. To prevent this, you should take Docfenofi 1 hour before taking the bile acid sequestrant, or 4–6 hours after taking it. Examples of bile acid sequestrants include:

  • cholestyramine
  • colesevelam
  • colestipol

Also, taking Docfenofi with cholesterol drugs called statins raises your risk of rhabdomyolysis. This is a serious condition that breaks down muscle. Examples of statin drugs include:

  • atorvastatin
  • fluvastatin
  • lovastatin
  • pitavastatin
  • pravastatin
  • rosuvastatin
  • simvastatin

Liver damage warning

Docfenofi can cause abnormal results in tests of liver function. These abnormal results can indicate liver damage. This drug can also cause other liver damage and inflammation after years of use.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Markedly elevated levels of serum triglycerides (e.g. >2,000 mg/dL) may increase the risk of developing pancreatitis. The effect of Docfenofi tablet therapy on reducing this risk has not been adequately studied.

Docfenofi was not shown to reduce coronary heart disease morb >see Warnings and Precautions (5.1) ].

Docfenofi is a prescription drug. It comes in two forms: oral tablet and oral capsule.

The oral tablet is available as the brand-name drugs Fenoglide, Tricor, and Triglide. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Docfenofi may be used as part of a combination therapy. This means you may need to take it with other cholesterol drugs, such as statins.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of Docfenofi: myalgia, rhabdomyolysis, pancreatitis, acute renal failure, muscle spasm, hepatitis, cirrhosis, anemia, arthralgia, decreases in hemoglobin, decreases in hematocrit, white blood cell decreases, asthenia, and severely depressed HDL cholesterol levels. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the entire FDA prescribing information for Docfenofi (Docfenofi)

Rated Docfenofi for Hyperlipoproteinemia Report

I haven't been taking it long enough to have had my cholesterol levels re-checked, but have had no side effects other than a slight headache.

SL >Lower Your Cholesterol, Save Your Heart See Slideshow

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

In rare cases, Docfenofi can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine.

Also call your doctor at once if you have:

  • sharp stomach pain spreading to your back or shoulder blade;
  • loss of appetite, stomach pain just after eating a meal;
  • jaundice (yellowing of the skin or eyes);
  • fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding;
  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
  • swelling, warmth, or redness in an arm or leg.

Common side effects may include:

  • runny nose, sneezing; or
  • abnormal laboratory tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Docfenofi (Docfenofi)

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rate observed in clinical practice.

Adverse reactions reported by 2% or more of patients treated with Docfenofi (and greater than placebo) during the double-blind, placebo-controlled trials, regardless of causality, are listed in Table 1 below. Adverse events led to discontinuation of treatment in 5.0% of patients treated with Docfenofi and in 3.0% treated with placebo. Increases in liver function tests were the most frequent events, causing discontinuation of Docfenofi treatment in 1.6% of patients in double-blind trials.

Table 1: Adverse Reactions Reported by 2% or More of Patients Treated with Docfenofi and Greater than Placebo During the Double-Blind, Placebo-Controlled Trials


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