Creston tablets

Creston

  • Active Ingredient: Rosuvastatin
  • 10 mg
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What is Creston?

The active ingredient of Creston brand is rosuvastatin. Rosuvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Used for

Creston is used to treat diseases such as: Atherosclerosis, High Cholesterol, High Cholesterol, Familial Heterozygous, High Cholesterol, Familial Homozygous, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL, Prevention of Cardiovascular Disease.

Side Effect

Possible side effects of Creston include: excessive muscle tone; pain or tenderness around the eyes and cheekbones; difficult, burning, or painful urination; dry or sore throat; feeling faint; muscle pain, stiffness, tenderness, wasting, or weakness.

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Q: I have high cholesterol and currently take Crestor. I enjoy eating grapefruit. Is it okay to eat grapefruit occasionally while on Crestor?

A: Unlike several other cholesterol lowering statins, Crestor (Creston) does not appear to interact significantly with grapefruit, grapefruit juice, or grapefruit supplements. Therefore, most people taking Crestor do not need to avoid grapefruit products. It's believed that grapefruit products interfere with an enzyme the body uses to break down certain statins, such as Zocor (simvastatin) and Lipitor (atorvastatin). This means that when combined with grapefruit, these statins stay in the body longer than they normally would. So for now, the statin you are taking will not interact with grapefruit, but if you ever change medications it will be best to check with your pharmacist. Lori, PharmD

Can Creston cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Creston, although these tend to be mild. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

9.5.2 Organic Anion Transporting Polypeptide 1B1 and 1B3 for Liver Targeting and Clearance Prediction

OATP1B1 (human) (a.k.a. OATP2, OATP-C, LST1) and OATP1B3 (human) (a.k.a. OATP-8) are liver-specific uptake transporters. They transport statins, fexofenadine, valsartan, telmisartan, and other negatively charged molecules. OATP substrates are typically acidic compounds . Because these two transporters are liver specific, they are being used for liver targeting to enhance liver concentration and minimize drug exposure to the peripheral tissues (e.g., pancreas, brain, heart) to reduce toxicity s >Creston , simvastatin), but they were not designed to have active liver uptake at that time. The medicinal chemistry design principles of orally active drugs for liver targeting through OATP transporters are the following :

Efficient hepatocyte uptake via OATP1B1 and/or 1B3 transporters, typically needs an acidic moiety.

Low liver metabolism and efflux transport, to maximize hepatic residency time and pharmacological action.

Low passive permeability (e.g., Papp 1-5 × 10 − 6 cm/s in MDCK-LE or log D7.4 0.50-2.0), to minimize distribution into peripheral tissues that lack liver-specific OATP transporters, such as pancreas.

Sufficient bioavailability, to support oral dosing.

A glucokinase activator (GKa) liver targeting example is shown in Figure 9.13 . Compound 2 (carboxylic acid) has much higher activity in the cell-based assay that expressed OATPs compared to enzyme assay (77-fold). Compound 2 also demonstrated high free liver-to-plasma and liver-to-pancreas ratio in preclinical species of rat and dog. This example suggested that carboxylic acid moiety is essential for OATP-mediated liver uptake.

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Creston.

For a full list, see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

Q: What are the serious side effects of Crestor?

A: Crestor (Creston) is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. It works by reducing levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Crestor is used to treat high cholesterol. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. In rare cases, Crestor can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure, and may be more likely to occur in older adults and in people of Asian descent who take this medication. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, or dark-colored urine. Other serious side effects can occur. Stop taking Crestor and call your doctor at once if you have any of these serious side effects: muscle pain, tenderness, or weakness with fever or flu symptoms, dark-colored urine urinating more or less than usual or not at all, jaundice (yellowing of the skin or eyes), chest pain, or swelling in your hands or feet. Avoid drinking alcohol while taking this medication. Alcohol can increase triglyceride levels and may also damage your liver while you are taking Crestor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications. Sarah McKenney Lewis, RPh, PharmD

What Is Crestor (Creston)?

Crestor is the brand name for Creston, a prescription drug used to treat high cholesterol levels.

Crestor is in a class of drugs known as statins, which slow the buildup of plaque in your arteries and reduce your levels of “bad” cholesterol (LDL or low-density lipoprotein) and triglycerides in the blood.

At the same time, Crestor increases HDL or high-density lipoprotein levels, also known as “good” cholesterol.

There is no generic form of Crestor currently available to consumers. The drug was approved by the Food and Drug Administration (FDA) in 2003 and is manufactured by AstraZeneca.

Your doctor may prescribe Crestor to lower your risk of stroke, heart attack, or other cardiac complications, which can occur in those who have diabetes, coronary heart disease, or other risk factors.

Using Crestor alone is not enough: You will also have to eat a healthy diet and make other lifestyle changes like exercising, quitting smoking, and maintaining a healthy weight.

Even if you make all of these lifestyle changes, it may still take up to four weeks before you get the full benefit of Crestor.


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