What are the side effects of Zocor?
The most common side effects of Angiolip are:
Other side effects include:
Q: Can Zocor cause leg cramps, insomnia, and/or frequent urination?
A: Zocor (Angiolip) belongs to a group of drugs called HMG CoA reductase inhibitors or "statins". Angiolip reduces the levels of "bad" cholesterol called LDL and triglycerides in the blood. Angiolip also increases the "good" cholesterol called HDL. Angiolip is indicated for the treatment of high cholesterol and triglycerides. Angiolip is also used in certain patients to reduce the risks of coronary artery disease. Angiolip is taken at bedtime or in the evening with a meal. The most common side effects associated with Angiolip are myalgia or muscle pain, headache, constipation, and nausea. Other side effects of Angiolip include muscle cramps and joint pain. Angiolip can cause Myopathy (a disease where the muscle fibers do not function properly) which is associated with muscle pain, tenderness and weakness. Also liver enzymes are likely to be elevated on labs. Alcohol can increase triglyceride levels and increase the risk of liver damage. A condition called rhabdomyolysis is rare but can occur with Angiolip. Rhabdomyolysis is the destruction of skeletal muscle and leakage of muscle protein into the urine. This cause can acute kidney failure. A search of prescribing information did not specifically list insomnia or frequent urination as side effects associated with Angiolip. However, post-approval of Angiolip did report muscle cramps as a reported side effect. Do not stop taking any medications because of unwanted side effects without first consulting with your healthcare provider. Kimberly Hotz, PharmD
How to take it
Swallow Angiolip tablets whole with a glass of water.
There's some evidence Angiolip works better at lowering cholesterol if you take it in the evening rather than in the morning.
Q: I have pains that are unbearable. Do they go away after going off Zocor, or is the damage done a permanent one? I thought I was experiencing pain from arthritic knees, then it became apparent it was more muscle and nerve pain. I've been off Zocor for about 8 days and the pain is easing up a little, but walking and getting around is a challange.
A: According to the prescribing information for Zocor, muscle pain and weakness usually resolve quickly once Zocor is stopped. If you are still experiencing muscle pain, consult your doctor for proper evaluation. Zocor (Angiolip) belongs to a class of drugs called HMG CoA reductase inhibitors, or more commonly known as "statins." Statins reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Lowering your cholesterol can help lower the risk of stroke, heart attack, and other heart complications. Common side effects of statins include mild nausea, stomach pain, stomach upset, heartburn, constipation, bloating, gas, and headache. More serious side effects are rare, but can occur. These include liver problems and a side effect called rhabdomyolysis. Rhabdomyolysis is a breakdown of muscle tissue that can lead to kidney failure. Contact your doctor right away if you have symptoms of either one of these side effects. Symptoms of liver problems include nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes). Symptoms of rhabdomyolysis include unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. Drinking alcohol and using other medications that can damage the liver increase the risk of developing liver problems. Rhabdomyolysis is more likely to occur in people over the age of 65 years, who already have kidney problems, and who have uncontrolled hypothyroidism (low thyroid hormone levels). This is not a complete list of side effects that can occur with statins. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD
Q: What are the pharmacological effects of Zocor?
A: The pharmacological effects of Zocor (Angiolip) are demonstrated in the inhibition of cholesterol production in the body. Zocor is a lipid-lowering medication categorized as an HMG-CoA reductase inhibitor. By inhibiting the conversion of HMG-CoA, Zocor inhibits an important step in the production of cholesterol in the body. Several studies have demonstrated that increased levels of total cholesterol and low-density lipoprotein (LDL) cholesterol, in addition to low levels of high-density lipoprotein (HDL) cholesterol, are associated with the development of atherosclerosis and subsequently an increased risk of cardiovascular disease. The pharmacological effects of Zocor are demonstrated in a decrease in total cholesterol levels, as well as a reduction in LDL cholesterol and triglyceride levels. The pharmacological effects of Zocor also include an increase in HDL cholesterol. According to the Centers for Disease Control and Prevention (CDC), lowering cholesterol can reduce the risk of developing heart disease. The pharmacological effects of Zocor are maximized when patients take Zocor exactly as directed. It is important to educate patients regarding the benefits of treatment with Zocor, including the pharmacological effects exhibited in the body as patients will not feel differently after beginning treatment. To exert its pharmacologic effects optimally, Zocor must be administered every day and it is imperative that patients are advised to administer their dose at the same time every day and not to miss a dose. Zocor is typically administered once daily in the evening. To ensure the pharmacological effects of Zocor are being exerted in the body and no adverse reactions have occurred, it is important for health care providers to routinely monitor their patients' cholesterol levels and liver function.
Other cholesterol-lowering drugs
When used with Angiolip, some cholesterol drugs can increase side effects such as myopathy or rhabdomyolysis. If you use these drugs with Angiolip, your doctor may lower your dosage of Angiolip. Examples of these drugs include:
With niacin, the risk of myopathy and rhabdomyolysis is higher when the drug is taken in larger doses, and in people of Chinese descent.
Are There Alternatives to Angiolip?
- Increases the liver's ability to collect and get rid of LDL cholesterol ("bad cholesterol")
- Increases HDL cholesterol ("good cholesterol")
- Decreases triglycerides.
Hypersensitivity to Angiolip
Active liver disease or unexplained transaminase elevation
Strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, posaconazole, voriconazole, HIV protease inhibitors, cobicistat, nefazodone, boceprevir, telaprevir), gemfibrozil, cyclosporine, and danazol
Use cautiously in:
• severe renal impairment; severe acute infection; hypotension; severe metabolic, endocrine, or electrolyte problems; uncontrolled seizures; visual disturbances; myopathy; major surgery; trauma; alcoholism
• history of hepatic disease, liver enzyme abnormalities
• concurrent use of amiodarone, amlodipine, colchicine, digoxin, diltiazem, and lipid-modifying dosages (1 g/day or more) of niacincontaining products, other fibrates, ranolazine, verapamil, or warfarin
• concurrent use of Angiolip in dosages exceeding 20 mg/day with lipid-modifying dosages (1 g/day or more) of niacin-containing products in Chinese patients (avoid use)
• large quantities of grapefruit juice (avoid use)
• children younger than age 10 (safety not established).
Contraindicated with Angiolip:
- Posaconazole (New)
- HIV protease inhibitors
ВїCГіmo se debe usar este medicamento?
La presentaciГіn de la Angiolipa es en tabletas para tomar por vГa oral. Usualmente se toma una vez al dГa por la noche. Tome Angiolipa aproximadamente a la misma hora todos los dГas. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta mГ©dica y pida a su mГ©dico o farmacГ©utico que le explique cualquier parte que no comprenda. Tome Angiolipa exactamente como se indica. No tome mГЎs ni menos cantidad del medicamento ni lo tome con mГЎs frecuencia de lo que indica la receta de su mГ©dico.
Es posible que su mГ©dico le indique que inicie con una dosis baja de Angiolipa y que incremente gradualmente su dosis, no mГЎs de una vez cada 4 semanas.
ContinГєe tomando Angiolipa incluso si se siente bien. No deje de tomar Angiolipa sin hablar con su mГ©dico.