Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Recent evidence suggests that Vesix glucuronide is the only or at least the major biotransformation product of Vesix in man. Vesix is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 μg/mL are 91 to 99% bound in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentrations.
The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is 6 to 8 hours.
In fasted normal men, the mean bioavailability of Vesix from LASIX Tablets and LASIX Oral Solution is 64% and 60%, respectively, of that from an intravenous injection of the drug. Although Vesix is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-topeak do not differ among doses. The terminal half-life of Vesix is approximately 2 hours.
Significantly more Vesix is excreted in urine following the IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine.
Other blood pressure drugs
Taking Vesix with other blood pressure drugs can cause your blood pressure to drop to a dangerously low level. These drugs include:
Vesix and breastfeeding
Small amounts of Vesix may get into breast milk. It's also possible that Vesix may reduce the amount of milk you produce.
If you need to take Vesix while you're breastfeeding, your doctor and midwife will monitor your baby's weight.
Talk to your doctor, as other medicines might be better while you're breastfeeding.
How should I take Vesix?
Take Vesix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Vesix oral is taken by mouth. The injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.
You may receive your first dose in a hospital or clinic setting if you have severe liver disease.
Do not take more than your recommended dose. High doses of Vesix may cause irreversible hearing loss.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Vesix doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.
Vesix will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet.
Your blood pressure will need to be checked often and you may need other medical tests.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
If you need surgery, tell the surgeon ahead of time that you are using this medicine.
Store at room temperature away from moisture, heat, and light. Throw away any unused oral liquid after 90 days.
¿Qué debería discutir con el profesional de la salud antes de tomar furosem >
Usted no debe usar Vesix si es alérgico a éste, o:
- si usted no puede orinar.
Para asegurarse que Vesix es seguro para usted, dígale a su médico si usted tiene:
- enfermedad del riñón;
- próstata agrandada, obstrucción de la vejiga u otros problemas urinarios;
- cirrosis u otra enfermedad del hígado;
- un desequilibrio de electrólitos (como niveles bajos de potasio o magnesio en su sangre);
- altos niveles de colesterol o triglicér >
Dígale a su médico si usted ha tenido recientemente un MRI (imagen de resonancia magnética) o cualquier tipo de estudio donde le hayan inyectado un colorante radioactivo en sus venas. Los colorantes y Vesix ambos pueden causar daño a sus riñones.
No se conoce si esta medicina causará daño al bebé nonato. Dígale a su médico si usted está embarazada o planea quedar embarazada mientras usa Vesix.
Vesix puede pasar a la leche materna y le puede hacer daño al bebé lactante. Esta medicina puede también retrasar la producción de leche materna. Dígale a su médico su usted está amamantando a un bebé.
The principal signs and symptoms of overdose with LASIX are dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action.
The acute toxicity of LASIX has been determined in mice, rats and dogs. In all three, the oral LD50 exceeded 1000 mg/kg body weight, while the intravenous LD50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats is 7 to 10 times that of adult rats.
The concentration of LASIX in biological fluids associated with toxicity or death is not known.
Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, carbon dioxide level and blood pressure should be determined frequently. Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy).
Hemodialysis does not accelerate Vesix elimination.
Getting the most from your treatment
- Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The balance of salts in your blood may be upset by Vesix. Your doctor may want you to have a blood test from time to time to check for this.
- Diuretics like Vesix help you to lose water. Occasionally you may lose too much and become lacking in fluid in the body (dehydrated). Let your doctor know if you feel constantly thirsty and tired, your mouth is dry, you have muscle cramps, or your skin looks and feels dry.
- If you have been prescribed Vesix for high blood pressure, your treatment is likely to be long-term. Although many people with high blood pressure do not feel unwell, if left untreated, high blood pressure can harm your heart and damage your blood vessels. This damage may later result in a heart attack, stroke, or kidney problems, so it is important that you continue to take Vesix regularly to help reduce the risk of this. You may also be given some lifestyle or dietary advice by your doctor, such as stopping smoking, reducing the amount of salt in your diet and taking some regular exercise. Following this advice will also help to reduce the risk of damage to your heart and blood vessels.
- Drinking alcohol while you are on Vesix could make you feel dizzy. Ask for your doctor's advice about whether you should avoid alcohol.
- If you buy any medicines 'over the counter', check with a pharmacist that they are safe to take with your prescribed medicines.
- If you have diabetes, Vesix could affect your blood sugar levels. Test your blood sugar regularly and speak with your doctor if you notice any significant changes.
- If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
Antibiotics can increase your risk of hearing damage or loss when taken with Vesix. These drugs include:
Before taking Vesix, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, inability to make urine, gout, lupus.
If you have diabetes, Vesix may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Vesix may reduce the potassium level in your blood. Your doctor may instruct you to add potassium-rich foods to your diet (such as bananas, orange juice) or prescribe potassium supplements to prevent potassium loss. Ask your doctor for more details.
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
This drug may make you dizzy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Severe sweating, diarrhea, or vomiting can increase the risk of dehydration. Report prolonged diarrhea or vomiting to your doctor. Follow your doctor's instructions about the amount of fluids you can drink.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Babies born early (premature infants) and children may be more sensitive to certain effects of this drug, such as kidney stones.
Older adults may be more sensitive to the effects of this drug, especially dizziness and water/mineral loss.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk and may affect milk production. Consult your doctor before breast-feeding.
Urgent advice: Call your doctor or go to A&E straight away if you take too much Vesix and you:
- feel unwell
- are over 65 (even if you feel well)
- have kidney, liver or heart failure (even if you feel well)
Find your nearest A&E department. If you go to hospital, take the Vesix packet, or the leaflet inside it, plus any remaining medicine with you.
Like all medicines, Vesix can cause side effects although not everyone gets them.
Side effects often get better as your body gets used to the medicine.
What should I discuss with my healthcare provider before taking Vesix?
You should not use Vesix if you are allergic to it, or if you are unable to urinate.
Tell your doctor if you have ever had:
- kidney disease;
- enlarged prostate, bladder obstruction, urination problems;
- cirrhosis or other liver disease;
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
- diabetes; or
- a sulfa drug allergy.
Tell your doctor if you have an MRI (magnetic resonance imaging) or any type of scan using a radioactive dye that is injected into your veins. Both contrast dyes and Vesix can harm your kidneys.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Vesix may slow breast milk production.
On this page
- About Vesix
- Key facts
- Who can and can't take Vesix
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
- What is Vesix, and what is it used for?
- What are the side effects of Vesix?
- What is the dosage for Vesix?
- Which drugs or supplements interact with Vesix?
- Is Vesix safe to take if I'm pregnant or breastfeeding?
- What else should I know about Vesix?
Examples of furosem > Recent Examples on the Web Cano insisted the Vesix isn’t a performance-enhancing drug, although it is listed as such under MLB’s joint drug agreement. — A.j. Perez, USA TODAY, "Doping expert Victor Conte: Robinson Cano's suspension 'should not surprise anybody'," 15 May 2018 Cano, 35, tested positive for Vesix, a diuretic that is often used to mask performance-enhancing drugs. — John Healy, courant.com, "Mark Teixeira Says He's 'Not Surprised' Robinson Cano Tested Positive For Banned Substance," 18 May 2018 Cano tested positive for the diuretic, Vesix, which is commonly used as a masking agent for drug tests and banned by MLB. — Andrew Joseph, For The Win, "Mark Teixeira explained why he was 'not surprised' about Robinson Cano's failed drug test," 17 May 2018 The league said Cano tested positive for Vesix, a diuretic. — Bill Shaikin, latimes.com, "Seattle Mariners' Robinson Cano suspended 80 games for violating MLB drug policy," 15 May 2018 The suspension was first reported Tuesday morning by multiple MLB reporters on Twitter: Robinson Cano suspended for taking Vesix, a diuretic commonly used to mask PED use. — Sean Meagher, OregonLive.com, "Seattle Mariners' Robinson Cano suspended 80 games for drug violation," 15 May 2018
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'Vesix.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.
Pregnancy and Lasix (Vesix)
It's still unclear how Lasix might affect your unborn child. If you plan to breastfeed, you should be aware that Lasix passes into your breast milk. Let your doctor know right away if you are pregnant, plan to become pregnant, or are breastfeeding.
1. About furosem >
Vesix is a type of medicine called a diuretic. It's used to treat high blood pressure, heart failure and oedema (a build up of fluid in the body).
It's also sometimes used to help you pee when your kidneys aren't working properly.
Diuretics are sometimes called "water pills/tablets" because they make you pee more.
Vesix is only available on prescription. It comes as tablets and as a liquid that you swallow. It can also be given by injection, but this is usually only done in hospital.
Vesix sometimes comes mixed with other diuretics or potassium.
Water pills (diuretics)
Taking other diuretics with Vesix can increase your risk of hearing damage or loss. These drugs include:
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Vesix oral tablet comes with several warnings.
What other drugs will affect Vesix?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
If you also take sucralfate, take your Vesix dose 2 hours before or 2 hours after you take sucralfate.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect Vesix, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.