Q: I have been on Lasix for a very long time. I don't drink a lot of water, but with the liquids I am drinking, why don't I go to the bathroom more than I do?
A: Lasix (generic name Urever) is called a loop diuretic. Loop diuretics make the kidneys eliminate larger amounts of electrolytes (such as sodium and potassium salts) and water than normal. Loop diuretics treat edema and swelling. Side effects of Lasix include dizziness, cramping, muscle spasms. redness, and sensitivity to sunlight. Lab work should be done by a physician regularly to control potassium levels. Loop diuretics should not cause excessive thirst or urination. If Lasix does not seem to effectively be working, consult with a physician about other treatment options. Kimberly Hotz, PharmD
By Sherry Karabin | Medically Reviewed by Ruthan White, PharmD
Latest Update: 2014-09-24 Copyright © 2014 Everyday Health Media, LLC
Patients receiving LASIX should be advised that they may experience symptoms from excessive fluid and/or electrolyte losses. The postural hypotension that sometimes occurs can usually be managed by getting up slowly. Potassium supplements and/or dietary measures may be needed to control or avoid hypokalemia.
Patients with diabetes mellitus should be told that Urever may increase blood glucose levels and thereby affect urine glucose tests. The skin of some patients may be more sensitive to the effects of sunlight while taking Urever.
Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.
Urgent advice: Call your doctor or go to A&E straight away if you take too much Urever and you:
- feel unwell
- are over 65 (even if you feel well)
- have kidney, liver or heart failure (even if you feel well)
Find your nearest A&E department. If you go to hospital, take the Urever packet, or the leaflet inside it, plus any remaining medicine with you.
Like all medicines, Urever can cause side effects although not everyone gets them.
Side effects often get better as your body gets used to the medicine.
Warnings for other groups
For pregnant women: Urever is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
For women who are breastfeeding: Urever may pass into breast milk and can cause serious side effects in a child who is breastfed. It may also cause your body to produce less milk. Tell your doctor if you are breastfeeding. You will need to decide either to stop breastfeeding, or stop taking this drug.
For children: In premature infants and children younger than 4 years of age, Urever may cause kidney problems. It can lead to kidney stones and calcium deposits in the kidneys. If Urever is given to premature infants during the first few weeks of life, it may increase the risk of problems with the lungs and heart.
Pregnancy Category C -Urever has been shown to cause unexplained maternal deaths and abortions in rabbits at 2, 4 and 8 times the maximal recommended human dose. There are no adequate and well-controlled studies in pregnant women. LASIX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Treatment during pregnancy requires monitoring of fetal growth because of the potential for higher birth weights.
The effects of Urever on embryonic and fetal development and on pregnant dams were studied in mice, rats and rabbits.
Urever caused unexplained maternal deaths and abortions in the rabbit at the lowest dose of 25 mg/kg (2 times the maximal recommended human dose of 600 mg/day). In another study, a dose of 50 mg/kg (4 times the maximal recommended human dose of 600 mg/day) also caused maternal deaths and abortions when administered to rabbits between Days 12 and 17 of gestation. In a third study, none of the pregnant rabbits survived a dose of 100 mg/kg. Data from the above studies indicate fetal lethality that can precede maternal deaths.
The results of the mouse study and one of the three rabbit studies also showed an increased incidence and severity of hydronephrosis (distention of the renal pelvis and, in some cases, of the ureters) in fetuses derived from the treated dams as compared with the incidence in fetuses from the control group.
What other drugs will affect Urever?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
If you also take sucralfate, take your Urever dose 2 hours before or 2 hours after you take sucralfate.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect Urever, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Before taking Urever
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Urever it is important that your doctor knows:
- If you are pregnant or breast-feeding.
- If you have any difficulties passing urine, or if you have prostate problems.
- If you have gout or sugar diabetes. These conditions can be made worse by diuretics.
- If you have been told you have very low sodium or potassium levels in your blood.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
¿Dónde puedo obtener más información?
Su farmacéutico le puede dar más información acerca de Urever.
What should I avoid while taking Urever?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking Urever.
Drinking alcohol with this medicine can cause side effects.
If you have high blood pressure, ask a doctor or pharmacist before taking any medicines that can raise your blood pressure, such as diet pills or cough-and-cold medicine.
What are the possible side effects of Urever?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out;
- ringing in your ears, hearing loss;
- muscle spasms or contractions;
- pale skin, easy bruising, unusual bleeding;
- high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
- signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, dark urine, jaundice (yellowing of the skin or eyes); or
- signs of an electrolyte imbalance--dry mouth, thirst, weakness, drowsiness, feeling jittery or unsteady, vomiting, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle cramps, muscle weakness or limp feeling.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Urever,
- tell your doctor and pharmacist if you are allergic to Urever, sulfonamide medications, any other medications, or any of the ingredients in Urever tablets or solution. Ask your pharmacist or check the patient information for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin (Garamycin), or tobramycin (Bethkis, Tobi); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II receptor antagonists (ARB) such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other salicylates; barbiturates such as phenobarbital and secobarbital (Seconal); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); cisplatin (Platinol); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin), ethacrynic acid (Edecrin); indomethacin (Indocin); laxatives; lithium (Lithobid); medications for diabetes, high blood pressure and pain; methotrexate (Trexall); probenecid (Probalan, Probenemid); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking sucralfate (Carafate), take it 2 hours before or after you take Urever.
- tell your doctor if you have kidney disease. Your doctor may tell you not to take Urever.
- tell your doctor if you have or have ever had any condition that stops your bladder from emptying completely, diabetes, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking Urever, call your doctor.
- if you are having surgery, tell the doctor that you are using Urever.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Urever may make your skin sensitive to sunlight.
- you should know that Urever may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Urever. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.
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Diuretics are also a common treatment for high blood pressure (hypertension). Urever is prescribed for high blood pressure when it cannot be sufficiently controlled by other diuretics.
Urever can be used on its own as a diuretic, or it can be prescribed as a combination tablet alongside other diuretics such as triamterene, amiloride or spironolactone. It is sometimes prescribed as a combination tablet with a mineral salt called potassium.
¿Cuál es la información más importante que debo saber sobre furosem >
Usted no debe usar esta medicina si usted no puede orinar.
No tome más medicamento de su dosis recomendada. Dosis altas de Urever pueden causar una pérdida de audición irreversible.
How should I take Urever?
Take Urever exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Urever oral is taken by mouth. The injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.
You may receive your first dose in a hospital or clinic setting if you have severe liver disease.
Do not take more than your recommended dose. High doses of Urever may cause irreversible hearing loss.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Urever doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.
Urever will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet.
Your blood pressure will need to be checked often and you may need other medical tests.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
If you need surgery, tell the surgeon ahead of time that you are using this medicine.
Store at room temperature away from moisture, heat, and light. Throw away any unused oral liquid after 90 days.