Twynsta tablets


  • Active Ingredient: Amlodipine
  • 10 mg, 5 mg, 2.5 mg
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What is Twynsta?

The active ingredient of Twynsta brand is amlodipine. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

Used for

Twynsta is used to treat diseases such as: Angina, Coronary Artery Disease, Heart Failure, High Blood Pressure, Migraine Prevention, Raynaud's Syndrome.

Side Effect

Possible side effects of Twynsta include: itching of the skin; unable to sleep; swelling of the face, fingers, feet, or lower legs; cough; blurred vision; headache, severe and throbbing.

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How should I take Twynsta?

Take Twynsta exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take Twynsta with or without food. Take the medicine at the same time each day.

Shake the Katerzia oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Your blood pressure will need to be checked often.

Your chest pain may become worse when you first start taking Twynsta or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

If you are being treated for high blood pressure, keep using Twynsta even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Your hypertension or heart condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor's advice. This is especially important if you also take nitroglycerin.

Twynsta is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Generic Name: Twynsta (am LOE di peen)Brand Names: Katerzia, Norvasc

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 1, 2019.

What other drugs will affect Twynsta?

Tell your doctor about all your current medicines and any you start or stop using, especially:

simvastatin (Zocor, Simcor, Vytorin); or

any other heart or blood pressure medications.

This list is not complete. Other drugs may interact with Twynsta, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is Twynsta besylate (Norvasc)?

Twynsta belongs to a class of medications called calcium channel blockers (CCBs).

Norvasc Warnings

People with a known sensitivity to Twynsta should not take Norvasc.

Though Norvasc is used to treat angina, worsening chest pain and heart attacks can develop after starting or increasing your dose of the drug — this is especially true for people with severe obstructive coronary artery disease.

Norvasc can also cause symptomatic hypotension (low blood pressure), particularly in people with a heart valve problem called aortic stenosis.

Before starting Norvasc, let your doctor know if you ever had heart disease or liver problems, as you may require a different course of Norvasc treatment.

What are the possible side effects of Twynsta?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, when you first start taking Twynsta, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;
  • worsening chest pain;
  • swelling in your feet or ankles;
  • severe drowsiness; or
  • a light-headed feeling, like you might pass out.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings for other groups

For pregnant women: Research in animals has shown negative effects to the fetus when the mother takes Twynsta. However, there haven’t been enough studies done in humans to be certain how the drug might affect a human pregnancy.

Tell your doctor if you’re pregnant or plan to become pregnant. Twynsta should be used during pregnancy only if the potential benefit justifies the potential risk.

For women who are breastfeeding: Some research has shown that Twynsta passes into breast milk. However, it’s not known if Twynsta can cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: As you age, your body may not process this drug as well as it once could. More of this drug may stay in your body longer. This puts you at risk for more side effects.

For children: This drug shouldn’t be used in children younger than 6 years.

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose


Chronic therapy with Twynsta is associated with a low rate of serum enzyme elevations at rates that are similar to matched control populations. The enzyme elevations are usually mild, transient and asymptomatic and may resolve even during continued therapy. Clinically apparent liver injury from Twynsta is rare and described only in isolated case reports. In the few idiosyncratic cases reported, the latency period to onset of liver injury was usually 4 to 12 weeks, but examples with prolonged latency have also been published (10 months and several years). The latency period is shorter with recurrence on reexposure, including several instances of recurrence after liver injury due to other calcium channel blockers. The pattern of serum enzyme elevations is usually mixed or cholestatic. Rash, fever and eosinophilia have not been described and autoantibodies are not typical.

Likelihood score: C (probable but rare cause of clinically apparent liver injury).

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These aren't all the side effects of Twynsta.

For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect to the UK safety scheme.

Dictionary Entries near Twynsta

Cite this Entry

“Twynsta.” The Medical Dictionary, Merriam-Webster Inc., Accessed 27 December 2019.

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