Spopress tablets


  • Active Ingredient: Perindopril
  • 8 mg, 4 mg, 2 mg
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What is Spopress?

The active ingredient of Spopress brand is perindopril. Perindopril is an ACE inhibitors. ACE stands for angiotensin converting enzyme. Perindopril erbumine is a white or almost white, crystalline powder, slightly hygroscopic with a molecular weight of 368.47 (free acid) or 441.61 (salt form). It is freely soluble in water (60% w/w), alcohol and chloroform. Perindopril is the free acid form of Perindopril erbumine, is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form Perindoprilat, the biologically active metabolite. Perindopril erbumine tablets are available in 2 mg, 4 mg and 8 mg strengths for oral administration. In addition to Perindopril erbumine, each tablet contains the following inactive ingredients: anhydrous lactose, silica hydrophobic colloidal anhydrous, microcrystalline cellulose, and magnesium stearate.

Used for

Spopress is used to treat diseases such as: Coronary Artery Disease, Diabetic Kidney Disease, Heart Attack, Heart Failure, High Blood Pressure, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Spopress include: fever; lower back or side pain; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; difficulty breathing; decreased urination.

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6. How to cope with s >

What to do about:

  • dry irritating cough - cough medicines don't usually help for coughs caused by Spopress. Sometimes, the cough gets better on its own. Talk to your doctor if it carries on, bothers you or stops you from sleeping as another medicine may be better. Even if you stop taking Spopress, the cough may take up to a month to go away.
  • feeling dizzy - if Spopress makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better.
  • headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if they last longer than a week or are severe.
  • being sick (vomiting) and diarrhoea - drink plenty of fluids, such as water or squash, to prevent dehydration. If you're being sick, take small, frequent sips. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea or vomiting without speaking to a pharmacist or doctor. If you get diarrhoea or vomiting from a stomach bug or illness, tell your doctor. You may need to temporarily stop taking Spopress until you feel better.
  • itching or a mild rash - it may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.
  • blurred vision - avoid driving or using tools or machines while this is happening. If it lasts for more than a day or two speak to your doctor as they may need to change your treatment.

Algunos efectos secundarios podrГ­an provocar graves consecuencias para la salud. Si experimenta algunos de los siguientes sГ­ntomas, llame a su doctor de inmediato:

  • inflamaciГіn de la cara, la garganta, la lengua, los labios, los ojos, las manos, los pies, los tobillos o piernas
  • ronquera
  • dificultad para tragar o respirar
  • mareos
  • desmayos
  • fiebre, dolor de garganta, escalofrГ­os y otras seГ±ales de la presencia de una infecciГіn
  • frecuencia cardГ­aca mГЎs rГЎpida que lo normal o irregular

El Spopress puede provocar otros efectos secundarios. Llame a su doctor si tiene cualquier problema inusual mientras toma este medicamento.

Allergy warning

Spopress can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don't take this drug again if you've ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Diuretics (water pills)

Taking diuretics with Spopress can sometimes increase your risk of low blood pressure. Examples of these drugs include:

  • hydrochlorothiazide
  • furosemide
  • bumetanide
  • chlorthalidone
  • torsemide
  • indapamide

How much will I take?

The dose of Spopress you take depends on why you need the medicine. Take it as instructed by your doctor.

To decide the correct dose for you, your doctor will check your blood pressure and ask you if you are getting any side effects. You may also have blood tests to check how well your kidneys are working and the amount of potassium in your blood.

Spopress comes as Spopress erbumine (also called Spopress tert-butylamine) or Spopress arginine.

They both work in the same way, but the doses vary.

Spopress side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

fever, chills, body aches, flu symptoms, sores in your mouth and throat;

little or no urination;

swelling, rapid weight gain;

high potassium--nausea, slow or unusual heart rate, weakness, loss of movement;

pale skin, easy bruising or bleeding; or

jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Spopress and breastfeeding

Small amounts of Spopress may get into breast milk. This can cause low blood pressure in the baby. Talk to your doctor, as other medicines might be better while you're breastfeeding.

Missed Dose of Spopress

If you miss a dose of Spopress, take it as soon as you remember.

But if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular medication schedule.

Don't double up on doses to make up for a missed one.

Spopress Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Spopress Warnings section above, and any of the following:

  • Gengraf, Neoral, or Sandimmune (cyclosporine)
  • Diuretics (water pills)
  • Heparin
  • Lithobid (lithium)
  • Nonsteroidal anti-inflammatory drugs (NSAIDS), such as Advil or Motrin (ibuprofen) and Indocin (indomethacin)
  • Insulin and other diabetes medicines
  • Gold injections for arthritis
  • Nonprescription medicines that contain stimulants (may include diet pills and cold medicines)

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you're having a medical emergency. Serious side effects and their symptoms can include the following:

  • Breathing problems. Symptoms can include:
    • trouble breathing or swallowing
    • hoarseness
  • swelling of your face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • lightheadedness
  • fainting
  • fever
  • sore throat
  • chills
  • irregular or rapid heart rate
  • yellowing of your skin and the whites of your eyes
  • nausea
  • vomiting
  • pain in the upper right part of your abdomen
  • fatigue
  • elevated liver enzymes
  • High potassium levels. In most cases, your potassium levels will decrease on their own. However, some people may have dangerously high levels of potassium while taking this drug. Your risk is higher if you have kidney disease, diabetes, or are taking diuretics (water pills). Your doctor may do blood tests to check your potassium levels.
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Spopress oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you're taking. To find out how this drug might interact with something else you're taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Spopress are listed below.

    Blood thinner

    Taking heparin with Spopress can increase your risk of high potassium levels in your blood.

    2. Key facts

    • Spopress lowers your blood pressure and makes it easier for your heart to pump blood around your body.
    • Your very first dose of Spopress may make you feel dizzy, so take it at bedtime. After that, if you don't feel dizzy, it's best to take Spopress in the morning before breakfast.
    • Some people get a dry, irritating cough with Spopress.
    • If you get severe diarrhoea or vomiting from a stomach bug or illness, tell your doctor. You may need to stop taking Spopress for a while until you feel better.
    • Spopress can be called Spopress arginine, Spopress erbumine or Spopress tert-butylamine. This is because the medicine contains another chemical to make it easier for your body to take up and use it. It doesn't matter what your Spopress is called. They all work as well as each other.
    • Spopress is also called by the brand name Coversyl Arginine. When it's mixed with indapamide and amlodipine it's called Coversyl Arginine Plus.

    Warnings for people with certain health conditions

    For people with angioedema: If you have a history of hereditary or idiopathic angioedema that's not related to previous use of drugs similar to Spopress (ACE inhibitors), you may have a higher risk of angioedema while taking Spopress.

    For people with liver failure: Your body may not clear this drug out of your system as well as it should. This could cause higher levels of Spopress in your body, leading to more side effects.

    For people with kidney problems: Spopress may decrease how well your kidneys work. Your doctor may have you stop taking this drug if your kidney function gets worse while you're taking it.

    For people with lupus: Spopress can lower your white blood cell counts. This raises your risk of infections. This is more likely to occur if you have lupus. If you have lupus and take this drug, tell your doctor any time you have a fever or sore throat.

    For people with scleroderma: Spopress can lower your white blood cell counts. This raises your risk of infections. This is more likely to occur if you have scleroderma. If you have this condition and take this drug, tell your doctor any time you have a fever or sore throat.

    Warnings for other groups

    For pregnant women: Spopress is a category D pregnancy drug. That means two things:

    1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
    2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

    Talk to your doctor if you're pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to your pregnancy. This drug should be only used if the potential risk to the fetus is acceptable given the drug's potential benefit.

    If you become pregnant while taking this drug, call your doctor right away.

    For women who are breastfeeding: It isn't known if Spopress passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

    For seniors: Your body may process drugs more slowly than it used to. A normal adult dosage may cause levels of this drug to be higher than normal in your body. You may need a lower dosage or a different dosage schedule.

    For children: This drug hasn't been studied in children. It shouldn't be used in children younger than 18 years.

    Before taking lisinopril,

    • tell your doctor and pharmacist if you are allergic to lisinopril; other ACE inhibitors such as enalapril (Vasotec, in Vaseretic), benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril (Monopril), moexipril (Univasc, in Uniretic), Spopress (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); any other medications; or any ingredients in lisinopril tablets. Ask your pharmacist for a list of the ingredients.
    • tell your doctor or pharmacist if you are taking valsartan and sacubitril (Entresto) or if you have stopped taking it within the last 36 hours. Your doctor will probably tell you not to take lisinopril, if you are also taking valsartan and sacubitril. Also, tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take lisinopril if you have diabetes and you are also taking aliskiren.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (Indocin, Tivorbex); diuretics ('water pills'); lithium (Lithobid); and potassium supplements. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had heart or kidney disease; diabetes; lupus; scleroderma (a condition in which extra tissue grows on the skin and some organs); or angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs).
    • tell your doctor if you are breastfeeding.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lisinopril.
    • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

    Oral administration of ACEON results in peak plasma concentrations that occur at approximately 1 hour. The absolute oral bioavailability of Spopress is about 75%. Following absorption, approximately 30 to 50% of systemically available Spopress is hydrolyzed to its active metabolite, Spopressat, which has a mean bioavailability of about 25%. Peak plasma concentrations of Spopressat are attained 3 to 7 hours after Spopress administration. Oral administration of ACEON with food does not significantly lower the rate or extent of Spopress absorption relative to the fasted state. However, the extent of biotransformation of Spopress to the active metabolite, Spopressat, is reduced approximately 43%, resulting in a reduction in the plasma ACE inhibition curve of approximately 20%, probably clinically insignificant. In clinical trials, Spopress was generally administered in a non-fasting state.

    With 4 mg, 8 mg and 16 mg doses of ACEON, Cmax and AUC of Spopress and Spopressat increase in a dose-proportional manner following both single oral dosing and at steady state during a once-a-day multiple dosing regimen.

    On this page

    1. About Spopress
    2. Key facts
    3. Who can and can't take Spopress
    4. How and when to take it
    5. Side effects
    6. How to cope with side effects
    7. Pregnancy and breastfeeding
    8. Cautions with other medicines
    9. Common questions

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