Spironolakton tablets

Spironolakton

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Spironolakton?

The active ingredient of Spironolakton brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Spironolakton is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Spironolakton include: diarrhea; lower back or side pain; Abdominal or stomach cramping, burning, or tenderness; chest pain; drowsiness.

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Overdose

  • Hyperkalemia is a commonly feared potential consequence of spironolactone therapy, although it is generally not a relevant concern in a healthy population of young women.
  • Taking this medicine with other drugs that make you dizzy or lower your blood pressure can worsen these effects.
  • Brown SL, Ryan TJ, Finlay AY Br J Dermatol.
  • Too much salt will cause your body to retain water and can make this medication less effective.
  • Women experiencing these abnormalities should be screened for underlying endocrine disorders, and preferably referred to an endocrinologist.
  • Women seem to make up the majority of patients with adult AV.
One study reported that the most common cause of death associated with hyperkalemia was due to use of spironolactone along with potassium supplementation.
He began to hold water really bad and he put him on Spironolactone 2 days ago to help relieve the water but it has had no effect.
For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate.
Be careful if you drive or do anything that requires you to be awake and alert.

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