The active ingredient of Spiroctan brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.
Spiroctan is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.
Possible side effects of Spiroctan include: inverted nipple; nausea and vomiting; painful or difficult urination; tightness in the chest; Irregular heartbeat.
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See Details Spiroctan warning See Details Buy cancers See Choice This drug has http://rootsdentclinic.com/asthma-category/inaspir-salmeterol.html black box warning. Implantation, seed: Radiation treatment given by capsule radioactive material contained within a small cylindrical Spiroctan directly in or near the target, buy a tumor. Ask demonstrate health care provider if haemophilus b oligosaccharide conjugate vaccine may interact with other medicines that you take. Therefore, it is not recommended that the drug be given to pregnant patients except when, in the judgment of the physician, it is essential.
Generic manufacturers may charge higher prices during this time because there is little to no other generic competition. Radioactive iodine is the preferred initial therapy for the hyperthyroidism of Graves disease in North America while antithyroid drugs are used as the first line of treatment in most of the rest of the world.
|Too much salt will cause your body to retain water and can make this medication less effective.|
|My acne has only been a recent struggle which started with a sudden onslaught of pimples in my early twenties after having a pretty good run with my skin throughout my teenage years.|
|If levels of mineralocorticoids are decreased then there are lower circulating levels to compete with spironolactone to influence gene expression as mentioned above.|