Spirobeta tablets


  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Spirobeta?

The active ingredient of Spirobeta brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Spirobeta is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Spirobeta include: dizziness; increased thirst; cough or hoarseness; severe stomach pain; bleeding gums; chest pain; confusion; constipation.

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Pregnancy and Spirobeta

Spirobeta may pose risks to a developing fetus.

Some research suggests that Spirobeta has the potential to feminize male fetuses during early pregnancy and cause endocrine problems in late pregnancy by inhibiting the activity of male hormones (androgens).

In general, diuretics such as Spirobeta aren't recommended for pregnant women.

Unless the drug is absolutely necessary, it's not recommended for women who are breastfeeding because canrenone, a byproduct of Spirobeta, is excreted in breast milk.

Generic Name: Spirobeta (spir ON oh LAK tone)Brand Names: Aldactone, CaroSpir

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 9, 2018.

Spirobeta for Acne

Spirobeta is sometimes used off-label to treat women with persistent adult acne due to increased androgen levels, because the drug is able to inhibit the activity of sebaceous glands (small skin glands that releases an oily, lubricating substance called sebum).

The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess.


Spirobeta has caused tumors in laboratory animals. Talk to your doctor about the risks and benefits of using this medication for your condition.

Rated Spirobeta (Aldactone) for Acne Report

I actually take it for Hidradenitis Suppurativa and have been having great success with 100mg for the past 5 months. Extremely satisfied to find a long-term drug regiment that works, considering HS is such a difficult illness to manage. Only side effect is menstrual irregularity so I take oral birth control. 100% recommend this drug.

Rated Spirobeta (Aldactone) for Acne Report

I LOVE this stuff!! I’ve always suffered with acne as a teenager, but it came roaring back when I turned 30?? I went to my dermatologist who suggested 50 mg of Spirobeta, which didn’t clear up any of my hormonal acne. She upped the dosage to 100 mg every day followed with a topical gel (Aczone) and my skin was clear immediately! Best feeling ever!! I’ve been on it for a few years now and still loving it! Unfortunately, I had to stop taking this medicine as my OB said it can cause birth defects (my husband and I are trying to have kids) and my acne is back. It’s not worse than before, but it’s back. Time will only tell if it ever goes away, but it’s definitely not safe to take while pregnant or trying to get pregnant.

Rated Spirobeta (Aldactone) for Acne Report

On my 4th month of taking this drug at 25mg,I started to have side effects. Vertigo, headaches/dizziness. It cleared up my acne and I also lost 10lbs of water weight. My cycle is irregular since being of it. Every person is different. Just do the research and very careful. I’m currently taking a vitamin prescription by my dermatologist . So far so good.

How should I take Spirobeta?

Take Spirobeta exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not share this medicine with another person, even if they have the same symptoms you have.

You may take Spirobeta with or without food, but take it the same way each time.

While using Spirobeta, you may need frequent blood tests.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Spirobeta.

If you need surgery, tell the surgeon ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from heat, light, and moisture.

What should I avoid while taking Spirobeta?

Drinking alcohol can increase certain side effects of Spirobeta.

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking Spirobeta.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Spirobeta may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by diuretics and your doctor will want you to have a blood test from time to time to check for this.
  • Diuretics help you to lose water, so you can breathe or move more easily. If, however, you lose too much fluid, you may become dehydrated. This will make you feel thirsty and make your skin look and feel dry. Let your doctor know if this happens, as your dose may need to be adjusted.
  • Another sign of dehydration with Spirobeta is rapid weight loss after starting the tablets. Speak with your doctor if you notice this happening.
  • Because Spirobeta is a potassium-conserving diuretic, you should try to avoid things with a high potassium content, such as 'salt substitutes' or low-sodium salt. This is so the level of potassium in your body does not become too high.
  • Treatment with diuretics is usually long-term, so continue to take these tablets unless you are advised otherwise by your doctor.
  • If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

More common side effects

The more common side effects that can occur with Spirobeta include:

  • diarrhea and abdominal cramping
  • nausea and vomiting
  • high potassium levels
  • leg cramps
  • headache
  • dizziness
  • drowsiness
  • itching
  • irregular menstrual cycles or bleeding after menopause

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Rated Spirobeta (Aldactone) for Acne Report

Updating my progress on Spirobeta: I posted a 2 star rating 2 months in for cystic chin acne. Acne was getting severely worse and in new odd places on my face. Slowly increased from 25 to 100 mg. Improvement began 4 months in with 100 mg per day AND a time release minocycline for 2 months. Been off the minocycline for about a month now. Side effects are breast pain when period approaching and slightly shorter period cycle. Early on , I had severe facial dryness and had to use olive oil on my skin. Not so bad anymore with cereve pm moisturizer and retin-a only once a week. Currently my cystic acne feels cured after almost 6 months and I’m only dealing with small manageable pimples. My suggestion to girls suffering with cystic acne and reading these posts all the time like I was. is to start at a higher mg - and with a short round of antibiotic to get through the beginning. I think my 6 months of suffering could have been avoided. I wish I didn’t have to take a pill but too afraid of accutane and tired of hiding. I will repost if this is short lived due to the antibiotic round. Best wishes!

Missed Dose of Spirobeta

Take your missed dose of Spirobeta as soon as you remember it.

Skip your missed dose if it's almost time for your next dose.

Don't "double-dose" to make up for a missed dose.

Michael Stewart, Reviewed by Sid Dajani | Last edited 27 Aug 2019 | Certified by The Information Standard

Spirobeta is a diuretic, also known as a 'water tablet'.

It will make you go to the toilet more often to pass urine.

The most common side-effect is a mild stomach upset. This is not usually troublesome.

Rated Spirobeta (Aldactone) for Acne Report

So I'm currently on 3 months of being on this medication and my face and chest is almost completely clear. However, the acne on my back is still very severe, so I'm doing what the internet has recommended and going to do a round of doxycycline to see if that knocks out the inflammation. I've pretty much had all the negative side effects like dizziness, fainting, and spotting during my cycle. Everyone always says they noticed they have to pee all the time but I didn't notice that for me. I started on 50mg a day for a month, didn't see a difference, went up to 100mg a day and started seeing the clearance. So to everyone looking through this thread, it sucks but it seems like it takes severe acne sufferers a minimum of 3 months to start having clear skin. Even with the negative side effects I still choose to be on it because I'd rather have occasional mild dizziness versus horrific, painful acne all over my body. Its also a really cost effective treatment (like $10 at the pharmacy) so I'll stick with it and update this after trying a round of antibiotics. Fingers crossed!

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