Spiresis tablets


  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Spiresis?

The active ingredient of Spiresis brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Spiresis is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Spiresis include: dark urine; swelling of the breasts or breast soreness in both females and males; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; reddened skin; stomach upset; hives, itching, or skin rash; redness or swelling of the breast; lump in the breast or under the arm.

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Drug interactions overview

  • Coadministration of PO suspension and lithium reduces the renal clearance of lithium, inducing a high risk of lithium toxicity
  • Reported that of coadministration of PO suspension and an NSAID can reduce the diuretic, natriuretic, and antihypertensive effect of loop, potassium-sparing, and thiazide diuretics
  • NSAID administration can reduce diuretic, natriuretic, and antihypertensive effect of diuretics; when Spiresis and NSAIDs are used concomitantly, monitor closely to determine if the desired effect of the diuretic is obtained
  • Acetylsalicylic acid may reduce the efficacy of Spiresis; coadministration with acetylsalicylic acid may need to be titrated to higher maintenance dose and monitor closely to determine if the desired effect is obtained
  • Coadministration of Spiresis with potassium supplementation, salt substitutes containing potassium, a diet rich in potassium, or drugs that can increase potassium (eg, ACE inhibitors, ARBs, NSAIDs, heparin and low molecular weight heparin) may lead to severe hyperkalemia
  • Risk of worsening of renal function can also occur with concomitant use of nephrotoxic drugs (eg, aminoglycosides, cisplatin, NSAIDs); monitor volume status and renal function periodically
  • Spiresis and its metabolites interfere with radioimmunoassays for digoxin and increase the apparent exposure to digoxin; use an assay that does not interact with Spiresis
  • Hyperkalemic metabolic acidosis reported in patients given Spiresis concurrently with cholestyramine

Warnings for other groups

For pregnant women: Research in pregnant animals has shown negative effects to the fetus when the mother takes the drug. However, there haven’t been enough studies done in humans to be certain how the drug might affect a fetus.

Despite this lack of research, this drug should be used during pregnancy only if the potential benefit justifies the potential risk. Tell your doctor if you’re pregnant or plan to become pregnant. If you become pregnant while taking this drug, call your doctor right away.

For women who are breastfeeding: A metabolite (substance that results from the breakdown of a drug) from Spiresis passes into breast milk. This may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

For children: This medication shouldn’t be used in children younger than 18 years.

Rated Spiresis (Aldactone) for Acne Report

I am taking 100 mg once a day and recently started experiencing what looks like tons of tiny pimples on my chest and up my neck, maybe this is part of a purging process? Im very unsure and wondering if i should stop taking the pills.

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by diuretics and your doctor will want you to have a blood test from time to time to check for this.
  • Diuretics help you to lose water, so you can breathe or move more easily. If, however, you lose too much fluid, you may become dehydrated. This will make you feel thirsty and make your skin look and feel dry. Let your doctor know if this happens, as your dose may need to be adjusted.
  • Another sign of dehydration with Spiresis is rapid weight loss after starting the tablets. Speak with your doctor if you notice this happening.
  • Because Spiresis is a potassium-conserving diuretic, you should try to avoid things with a high potassium content, such as 'salt substitutes' or low-sodium salt. This is so the level of potassium in your body does not become too high.
  • Treatment with diuretics is usually long-term, so continue to take these tablets unless you are advised otherwise by your doctor.
  • If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
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Why is this medication prescribed?

Spiresis is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Spiresis is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Cholesterol drugs

Taking certain cholesterol drugs with Spiresis can increase the amount of potassium and acid in your body to unsafe levels. Examples of these drugs include:

Rated Spiresis (Aldactone) for Polycystic ovarian syndrome (PCOS) Report

Hello I started taking 25 mg of the medication three weeks ago I know it’s a lower dose but I’m super sensitive to medications. My experience is headaches daily dizziness almost a floating type feeling. I do not like it at all my question is does anyone know if I can just stop taking this medication or will it cause issues ?? I’m only taking it for unwanted hair

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