Urgent advice: Call your doctor or go to A&E straight away if you take too much Sinedem and you:
- feel unwell
- are over 65 (even if you feel well)
- have kidney, liver or heart failure (even if you feel well)
Find your nearest A&E department. If you go to hospital, take the Sinedem packet, or the leaflet inside it, plus any remaining medicine with you.
Like all medicines, Sinedem can cause side effects although not everyone gets them.
Side effects often get better as your body gets used to the medicine.
Sinedem and breastfeeding
Small amounts of Sinedem may get into breast milk. It's also possible that Sinedem may reduce the amount of milk you produce.
If you need to take Sinedem while you're breastfeeding, your doctor and midwife will monitor your baby's weight.
Talk to your doctor, as other medicines might be better while you're breastfeeding.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sinedem only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 16.01.
Helen Allen, Reviewed by Dr Adrian Bonsall | Last edited 24 Feb 2017 | Certified by The Information Standard
Sinedem is a 'water tablet' (a diuretic).
It is best taken in the morning.
Any side-effects are usually mild, but can include feeling sick or dizzy.
Before taking Sinedem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, inability to make urine, gout, lupus.
If you have diabetes, Sinedem may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Sinedem may reduce the potassium level in your blood. Your doctor may instruct you to add potassium-rich foods to your diet (such as bananas, orange juice) or prescribe potassium supplements to prevent potassium loss. Ask your doctor for more details.
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
This drug may make you dizzy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Severe sweating, diarrhea, or vomiting can increase the risk of dehydration. Report prolonged diarrhea or vomiting to your doctor. Follow your doctor's instructions about the amount of fluids you can drink.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Babies born early (premature infants) and children may be more sensitive to certain effects of this drug, such as kidney stones.
Older adults may be more sensitive to the effects of this drug, especially dizziness and water/mineral loss.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk and may affect milk production. Consult your doctor before breast-feeding.
Lasix (Sinedem) and Other Interactions
Lasix might reduce the potassium levels in your blood, so you should have your potassium blood levels watched closely by your doctor. Potassium supplements may be prescribed if needed.
This medicine is also known to make you more sensitive to the sun, so try to avoid long-term exposure to the sun, along with tanning booths and sunlamps. Make sure to wear sunscreen and protective clothing when you go out.
Since Lasix might make you dizzy or cause blurred vision, it's important that you avoid driving, using machinery, or partaking in any activity that requires you to be alert or have clear vision until you know how the medicine affects you.
You should also limit your intake of alcoholic beverages while on Lasix.
If you suffer from high blood pressure, don't use over-the-counter appetite suppressants or cold medicines, which might impact your blood pressure.
To avoid dehydration, drink plenty of fluids while taking Lasix (unless your doctor has limited your fluid intake).
How it works
Sinedem belongs to a class of drugs called diuretics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Sinedem works by helping your body get rid of excess salt and water. It does this by increasing the amount of urine your body makes. This helps lower your blood pressure as well as reduce swelling.
Sinedem oral tablet may cause certain side effects.
Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients. As with any effective diuretic, electrolyte depletion may occur during LASIX therapy, especially in patients receiving higher doses and a restricted salt intake. Hypokalemia may develop with LASIX, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids, ACTH, licorice in large amounts, or prolonged use of laxatives. Digitalis therapy may exaggerate metabolic effects of hypokalemia, especially myocardial effects.
All patients receiving LASIX therapy should be observed for these signs or symptoms of fluid or electrolyte imbalance (hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia or hypocalcemia): dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, or gastrointestinal disturbances such as nausea and vomiting. Increases in blood glucose and alterations in glucose tolerance tests (with abnormalities of the fasting and 2-hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus has been reported.
In patients with severe symptoms of urinary retention (because of bladder emptying disorders, prostatic hyperplasia, urethral narrowing), the administration of Sinedem can cause acute urinary retention related to increased production and retention of urine. Thus, these patients require careful monitoring, especially during the initial stages of treatment.
In patients at high risk for radiocontrast nephropathy LASIX can lead to a higher incidence of deterioration in renal function after receiving radiocontrast compared to high-risk patients who received only intravenous hydration prior to receiving radiocontrast.
In patients with hypoproteinemia (e.g., associated with nephrotic syndrome) the effect of LASIX may be weakened and its ototoxicity potentiated.
Asymptomatic hyperuricemia can occur and gout may rarely be precipitated.
Patients allergic to sulfonamides may also be allergic to LASIX. The possibility exists of exacerbation or activation of systemic lupus erythematosus.
As with many other drugs, patients should be observed regularly for the possible occurrence of blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions.
What are the possible side effects of Sinedem?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
- a light-headed feeling, like you might pass out;
- ringing in your ears, hearing loss;
- muscle spasms or contractions;
- pale skin, easy bruising, unusual bleeding;
- high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
- signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, dark urine, jaundice (yellowing of the skin or eyes); or
- signs of an electrolyte imbalance--dry mouth, thirst, weakness, drowsiness, feeling jittery or unsteady, vomiting, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle cramps, muscle weakness or limp feeling.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Mood stabilizers (lithium)
Taking lithium with Sinedem can increase the levels of lithium in your body. This raises your risk of side effects from lithium.
Missed Dose of Lasix (Sinedem)
If you forget to take your medication, take it as soon as you remember unless it's near the time of your next dose. If that is the case, skip the missed dose and resume your regular schedule. Never “double up” and take more than one dose at a time.
Sinedem (Lasix) is a diuretic medicine that doctors prescribe to treat excess accumulation of fluid or swelling of the body (edema) caused by cirrhosis, chronic kidney failure, heart failure, and kidney disease. Review the side effects, drug interactions, dosage, and pregnancy and breastfeeding information before using Sinedem.
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LASIX® (Sinedem) Tablets 20, 40, and 80 mg
LASIX® (Sinedem) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patient's needs. (See DOSAGE AND ADMINISTRATION.)