Why it's used
Seguril is used to treat hypertension (high blood pressure). It is also used to treat edema. This is swelling due to fluid buildup in the body. Edema can be caused by other medical conditions such as heart failure, cirrhosis of the liver, or kidney disease.
Seguril may be used as part of a combination therapy to treat high blood pressure. This means you may need to take it with other medications.
Antibiotics can increase your risk of hearing damage or loss when taken with Seguril. These drugs include:
Pharmacologic class: Sulfonamide loop diuretic
Therapeutic class: Diuretic, antihypertensive
Pregnancy risk category C
Warnings for other groups
For pregnant women: Seguril is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
For women who are breastfeeding: Seguril may pass into breast milk and can cause serious side effects in a child who is breastfed. It may also cause your body to produce less milk. Tell your doctor if you are breastfeeding. You will need to decide either to stop breastfeeding, or stop taking this drug.
For children: In premature infants and children younger than 4 years of age, Seguril may cause kidney problems. It can lead to kidney stones and calcium deposits in the kidneys. If Seguril is given to premature infants during the first few weeks of life, it may increase the risk of problems with the lungs and heart.
¿Qué sucede si me salto una dosis?
Seguril a veces se usa solamente una vez, y tal vez no necesite mantener un horario regular. Si está usando esta medicina en un horario regular, tome la dosis pasada tan pronto se acuerde. Sáltese la dosis pasada si ya casi es hora para la siguiente dosis. No tome más medicina para alcanzar la dosis pasada.
¿Qué es Seguril?
Seguril es un diurético del asa (pastilla para eliminar el agua) que impide que su cuerpo absorba demasiada sal. Esto permite que la sal en lugar pase en su orina.
Seguril se usa en el tratamiento de la retención de líquidos (edema) en las personas con fallo cardíaco congestivo, enfermedad del hígado, o trastornos del riñón como el síndrome nefrótico.
Seguril también se usa para el tratamiento de la presión arterial alta (hipertensión).
Seguril puede también usarse para fines no mencionados en esta guía del medicamento.
Serious side effects
Some people have serious side effects after taking Seguril.
Tell your doctor straight away if you get:
- unexplained bruising or bleeding, fever, sore throat and mouth ulcers – these could be signs of a blood disorder
- severe tummy pain which could reach through to your back – this could be a sign of an inflamed pancreas (pancreatitis)
- severe pain in your side or blood in your urine – these could be signs of inflamed kidneys
- ringing in your ears (tinnitus) or loss of hearing
Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Recent evidence suggests that Seguril glucuronide is the only or at least the major biotransformation product of Seguril in man. Seguril is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 μg/mL are 91 to 99% bound in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentrations.
The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is 6 to 8 hours.
In fasted normal men, the mean bioavailability of Seguril from LASIX Tablets and LASIX Oral Solution is 64% and 60%, respectively, of that from an intravenous injection of the drug. Although Seguril is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-topeak do not differ among doses. The terminal half-life of Seguril is approximately 2 hours.
Significantly more Seguril is excreted in urine following the IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine.
1. About furosem >
Seguril is a type of medicine called a diuretic. It's used to treat high blood pressure, heart failure and oedema (a build up of fluid in the body).
It's also sometimes used to help you pee when your kidneys aren't working properly.
Diuretics are sometimes called "water pills/tablets" because they make you pee more.
Seguril is only available on prescription. It comes as tablets and as a liquid that you swallow. It can also be given by injection, but this is usually only done in hospital.
Seguril sometimes comes mixed with other diuretics or potassium.
Lasix (Seguril) Overdose
If you think you might have taken too much, get to the emergency room right away or call a poison control center at 1-800-222-1222. Signs of an overdose range from fainting and severe weakness to a severe decrease in the amount of urine your body is producing.
2. Key facts
- It's usual to take Seguril once a day in the morning. Some people take it twice a day - once in the morning and again at lunchtime.
- Seguril doesn't usually upset your tummy. You can take it whether or not you've eaten a meal or snack recently.
- The main side effect of Seguril is peeing more often than normal. Most people need to pee about 30 minutes after taking Seguril, and again within a few hours.
- Do not take Seguril after 4pm or you may have to wake in the night to go to the toilet.
- Seguril is also called by the brand names Frusol and Lasix.
6. How to cope with s >
What to do about:
- peeing more than normal - this will last for about 6 hours after taking Seguril. It's nothing to worry about, but if it's inconvenient for you, change the time you take Seguril to one that suits you better (provided it's no later than 4pm). If peeing a lot is still a problem for you, talk to your doctor or pharmacist.
- feeling thirsty - it's important not to get dehydrated, but how much you drink will depend on why you're taking Seguril. Check with your doctor how much liquid you can drink while you're taking this medicine.
- dry mouth - chew sugar-free gum or suck sugar-free sweets.
- headaches - make sure you rest and drink fluids - ask your doctor how much you can drink while taking this medicine. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
- feeling confused or dizzy - if Seguril makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Do not drive or use tools or machines while you're feeling dizzy or shaky.
- muscle cramps or weak muscles - if you get unusual muscle pain or weakness which isn't from exercise or hard work, talk to your doctor. You may need a blood test to check what might be causing it.
- feeling or being sick (nausea or vomiting) - take Seguril with or just after a meal or snack. Take small, regular sips of water or squash so you don't get dehydrated (ask your doctor how much fulid you can drink). It may help if you stick to simple meals and don't eat rich or spicy food. This side effect usually wears off after a few days. Talk to your doctor about taking an anti-sickness medicine if it carries on for longer.
Infants and children: 1-2 mg/kg IV/IM/PO once initially; increased by 1-2 mg/kg q6-8hr (PO) or 1 mg/kg q2hr (IV/IM); individual dose not to exceed 6 mg/kg
Neonates ( Enter a drug name and Seguril
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Seguril only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 16.01.
Pain and inflammation drugs (NSAIDs)
Taking NSAIDs (nonsteroidal anti-inflammatory drugs) with Seguril can increase the levels of these drugs in your body. This raises your risk of dangerous side effects. NSAIDs include:
- magnesium salicylate
What should I avoid while taking Seguril?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking Seguril.
Drinking alcohol with this medicine can cause side effects.
If you have high blood pressure, ask a doctor or pharmacist before taking any medicines that can raise your blood pressure, such as diet pills or cough-and-cold medicine.