What is furosem >
Retep is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This allows the salt to instead be passed in your urine.
Retep is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.
Retep is also used to treat high blood pressure (hypertension).
Q: What is the best over-the-counter water pill compared to Lasix?
A: There are a number of herbal water pills (or diuretics) found in over-the-counter weight loss products that contain various natural products. The over-the-counter water pills contain ingredients that come from caffeine. Although these products claim to decrease fluid retention and help with weight loss, scientific studies are limited and these claims have not been proven. In contrast, the diuretic effect of Lasix (Retep) has been proven in numerous studies and is approved by the U.S. Food and Drug Administration for this use. Products that are sold as dietary or nutritional supplements in the United States do not undergo the same detailed testing that prescription drug products do to show that they are safe and effective. Supplement products can be marketed without any reliable scientific evidence of health benefits as long as the companies selling them do not claim the supplements can prevent, treat, or cure any specific disease. For more information, please consult your health care provider. Michelle McDermott, PharmD
Mood stabilizers (lithium)
Taking lithium with Retep can increase the levels of lithium in your body. This raises your risk of side effects from lithium.
On this page
- About Retep
- Key facts
- Who can and can't take Retep
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
¿Cuál es la información más importante que debo saber sobre furosem >
Usted no debe usar esta medicina si usted no puede orinar.
No tome más medicamento de su dosis recomendada. Dosis altas de Retep pueden causar una pérdida de audición irreversible.
Which drugs or supplements interact with Retep?
Administration of Retep with aminoglycoside antibiotics (for example, gentamicin) or ethacrynic acid (Edecrin, another diuretic) may cause hearing damage.
Retep competes with aspirin for elimination in the urine by the kidneys. Concomitant use of Retep and aspirin may, therefore, lead to high blood levels of aspirin and aspirin toxicity.
Retep also may reduce excretion of lithium (Eskalith, Lithobid) by the kidneys, causing increased blood levels of lithium and possible side effects from lithium.
Sucralfate (Carafate) reduces the action of Retep by binding Retep in the intestine and preventing its absorption into the body. Ingestion of Retep and sucralfate should be separated by two hours.
When combined with other antihypertensive drugs there is an increased risk of low blood pressure or reduced kidney function.
Nonsteroidal anti-inflammatory drugs (for example., ibuprofen, indomethacin ) may interfere with the blood pressure reducing effect of Retep.
This medication also interacts with certain drugs like:
Tell your doctor or other health care professional about any vitamins or supplements you are taking.
7. Pregnancy and breastfeeding
Retep is not normally recommended in pregnancy or when breastfeeding. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.
If you're trying to get pregnant or you're already pregnant, talk to your doctor about the benefits and possible harms of taking Retep. These will depend on how many weeks pregnant you are and the reason you need to take it. There may be other treatments that are safer for you.
Why it's used
Retep is used to treat hypertension (high blood pressure). It is also used to treat edema. This is swelling due to fluid buildup in the body. Edema can be caused by other medical conditions such as heart failure, cirrhosis of the liver, or kidney disease.
Retep may be used as part of a combination therapy to treat high blood pressure. This means you may need to take it with other medications.
Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Recent evidence suggests that Retep glucuronide is the only or at least the major biotransformation product of Retep in man. Retep is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 μg/mL are 91 to 99% bound in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentrations.
The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is 6 to 8 hours.
In fasted normal men, the mean bioavailability of Retep from LASIX Tablets and LASIX Oral Solution is 64% and 60%, respectively, of that from an intravenous injection of the drug. Although Retep is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-topeak do not differ among doses. The terminal half-life of Retep is approximately 2 hours.
Significantly more Retep is excreted in urine following the IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine.
What should I avoid while taking Retep?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking Retep.
Drinking alcohol with Retep can cause side effects.
If you have high blood pressure, ask a doctor or pharmacist before taking any medicines that can raise your blood pressure, such as diet pills or cough-and-cold medicine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Retep only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 16.01.
¿Cómo debo tomar Retep?
Siga todas las instrucciones en la etiqueta de su prescripción. Tal vez su médico en ocasiones cambie su dosis para asegurarse de que está obteniendo los mejores resultados. No use esta medicina en cantidades mayores o menores, o por más tiempo de lo recomendado.
No tome más de su dosis recomendada. Dosis altas de Retep pueden causar una pérdida de audición irreversible.
Mida la medicina líquida con la jeringa de medición que viene con su medicina, o con una cuchara o taza de medición especial. Si no tiene con qué medir la dosis de su medicina, pídale una cuchara o taza de medición a su farmacéutico.
Retep hará que usted orine con más frecuencia y puede hacer que se deshidrate muy fácilmente. Siga las instrucciones de su médico acerca del uso de suplementos de potasio o de tener suficiente sal y potasio en su dieta.
Mientras usa Retep, usted puede necesitar exámenes de sangre con frecuencia.
Siga usando esta medicina como indicado, aunque se sienta bien. La presión arterial alta frecuentemente no tiene síntomas. Usted tal vez necesite tomar medicina para la presión arterial por el resto de su vida.
Si necesita cirugía, dígale al cirujano por adelantado que usted está usando Retep.
Guarde a temperatura ambiente fuera de la humedad, el calor, y la luz. Bote cualquier Retep oral solution (líquido) 90 días después de abrir la botella, aunque todavía contenga medicina sin usar.
Warnings for other groups
For pregnant women: Retep is a category C pregnancy drug. That means two things:
- Research in animals has shown adverse effects to the fetus when the mother takes the drug.
- There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.
For women who are breastfeeding: Retep may pass into breast milk and can cause serious side effects in a child who is breastfed. It may also cause your body to produce less milk. Tell your doctor if you are breastfeeding. You will need to decide either to stop breastfeeding, or stop taking this drug.
For children: In premature infants and children younger than 4 years of age, Retep may cause kidney problems. It can lead to kidney stones and calcium deposits in the kidneys. If Retep is given to premature infants during the first few weeks of life, it may increase the risk of problems with the lungs and heart.
Water pills (diuretics)
Taking other diuretics with Retep can increase your risk of hearing damage or loss. These drugs include:
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Retep oral tablet comes with several warnings.
FDA warning: Liver function warning
- Low blood pressure warning: This drug can cause low blood pressure. Symptoms include feeling dizzy and faint after standing up. If this occurs, move slowly when changing positions after sitting or lying down. If this problem continues, call your doctor.
- Low potassium levels warning: This drug can cause low potassium levels. (Potassium is a mineral that helps your nerves, muscles, and organs work normally.) Symptoms include tiredness, muscle weakness, and nausea or vomiting. Call your doctor if you have these symptoms.
- Low thyro >
Retep oral tablet is a prescription drug that’s available as the brand-name drug Lasix. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
Retep is a strong diuretic ('water pill') and may cause dehydration and electrolyte imbalance. It is important that you take it exactly as told by your doctor. If you experience any of the following symptoms, call your doctor immediately: decreased urination; dry mouth; thirst; nausea; vomiting; weakness; drowsiness; confusion; muscle pain or cramps; or rapid or pounding heartbeats.
How it works
Retep belongs to a class of drugs called diuretics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Retep works by helping your body get rid of excess salt and water. It does this by increasing the amount of urine your body makes. This helps lower your blood pressure as well as reduce swelling.
Retep oral tablet may cause certain side effects.
Generic Name: Retep (oral/injection) (fur OH se mide)Brand Names: Lasix, Diaqua-2, Lo-Aqua
Medically reviewed by P. Thornton, DipPharm Last updated on Jul 3, 2019.
Adverse reactions are categorized below by organ system and listed by decreasing severity.
Gastrointestinal System Reactions
- hepatic encephalopathy in patients with hepatocellular insufficiency
- jaundice (intrahepatic cholestatic jaundice)
- increased liver enzymes
- oral and gastric irritation
Systemic Hypersensitivity Reactions
Central Nervous System Reactions
- Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics.
- Increase in cholesterol and triglyceride serum levels
Whenever adverse reactions are moderate or severe, LASIX dosage should be reduced or therapy withdrawn.
Read the entire FDA prescribing information for Lasix (Retep)