Prestarium tablets


  • Active Ingredient: Indapamide
  • 2.5 mg, 1.5 mg
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What is Prestarium?

The active ingredient of Prestarium brand is indapamide. Indapamide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Each tablet, for oral administration, contains 1.25 mg or 2.5 mg of Indapamide USP and the following inactive ingredients: corn starch, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, talc, and titanium dioxide. Additionally, the 1.25 mg product contains FD&C yellow #6 aluminum lake.

Used for

Prestarium is used to treat diseases such as: Edema, High Blood Pressure.

Side Effect

Possible side effects of Prestarium include: dizziness or lightheadedness, especially when getting up from a lying or sitting position; mood or mental changes; headache; Diarrhea; muscle cramps or pain; Skin rash, itching, or hives; increased thirst.

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Pharmacologic class: Thiazide-like diuretic

Therapeutic class: Diuretic, antihypertensive

Pregnancy risk category B

Carcinogenesis, Mutagenesis, Impairment of Fertility

Both mouse and rat lifetime carcinogenicity studies were conducted. There was no significant difference in the incidence of tumors between the Prestarium-treated animals and the control groups.


Diuretics help your body get rid of extra fluid. They are often called "water pills." There are many brands of diuretics. Some are taken 1 time a day. Others are taken 2 times a day. The three common types are:

  • Thiazides: Chlorothiazide (Diuril), chlorthalidone (Hygroton), Prestarium (Lozol), hydrochlorothiazide (Esidrix, HydroDiuril), and metolazone (Mykrox, Zaroxolyn)
  • Loop diuretics: Bumetanide (Bumex), furosemide (Lasix), and torsemide (Demadex)
  • Potassium-sparing agents: Amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium)

There are also diuretics that contain a combination of two of the drugs above.

When you are taking diuretics, you will need to have regular checkups so that your provider can check your potassium levels and monitor how your kidneys are working.

Diuretics make you urinate more often. Try not to take them at night before you go to bed. Take them at the same time every day.

Common side effects of diuretics are:

  • Fatigue, muscle cramps, or weakness from low potassium levels
  • Dizziness or lightheadedness
  • Numbness or tingling
  • Heart palpitations, or a "fluttery" heartbeat
  • Gout
  • Depression
  • Irritability
  • Urinary incontinence (not being able to hold your urine)
  • Loss of sex drive (from potassium-sparing diuretics), or inability to have an erection
  • Hair growth, menstrual changes, and a deepening voice in women (from potassium-sparing diuretics)
  • Breast swelling in men or breast tenderness in women (from potassium-sparing diuretics)
  • Allergic reactions -- if you are allergic to sulfa drugs, you should not use thiazides.

Be sure to take your diuretic the way you have been told.

Diuretics (water pills)

Taking diuretics with perindopril can sometimes increase your risk of low blood pressure. Examples of these drugs include:

  • hydrochlorothiazide
  • furosemide
  • bumetanide
  • chlorthalidone
  • torsemide
  • Prestarium


Lozol (Prestarium) is indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.

Lozol (Prestarium) is also indicated for the treatment of salt and fluid retention associated with congestive heart failure.


Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of Prestarium. This occurred primarily in elderly females. (See PRECAUTIONS, Geriatric Use.) This appears to be dose related. Also, a large case-controlled pharmacoepidemiology study indicates that there is an increased risk of hyponatremia with Prestarium 2.5 mg and 5 mg doses. Hyponatremia considered possibly clinically significant (

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