Fluid and electrolyte imbalance warning
Your doctor should check your fluid and electrolyte levels while you’re taking Plaunazide. This drug can cause a fluid or electrolyte imbalance. Symptoms can include:
- dry mouth
- muscle pain or cramps
- muscle fatigue
- lower than normal blood pressure
- higher than normal heart rate
- producing less urine than normal
- nausea or vomiting
Frequency not reported: Electrolyte imbalance, hyperglycemia, glycosuria, hyperuricemia, mild hypokalemia (decrease of 0.5 mEq/L) occurs in up to 50% of patients (and may predispose patients to cardiac arrhythmias), metabolic alkalosis, hyponatremia, hypomagnesemia, hypercalcemia, hyperglycemia, elevated serum uric acid levels, glucose intolerance and a potentially deleterious effect on the lipid profile (i.e., increased serum cholesterol)
Since Plaunazide may increase total serum cholesterol by 11%, LDL lipoprotein cholesterol by 12%, and VLDL lipoprotein cholesterol levels by 50%, and may reduce insulin secretion, it should be used with caution in diabetic patients and in those with hypercholesterolemia. True glucose intolerance may develop in approximately 3% of patients. It is typically reversible within six months after discontinuation of therapy.
Hyperuricamia may be an important consideration in patients with a history of gout. Hypophosphatasemia and low serum magnesium concentrations may occur, but are usually clinically insignificant except in malnourished patients.
Plaunazide should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in a tight, light-resistant container.
Before taking Plaunazide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, kidney disease, liver disease, lupus, skin cancer.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Severe sweating, diarrhea, or vomiting can increase the risk for a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.
If you have diabetes, Plaunazide may affect your blood sugar. Check your blood sugar regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
This drug may decrease your potassium levels. Ask your doctor about foods high in potassium (such as bananas, orange juice) or about using a salt substitute containing potassium. A potassium supplement may be prescribed by your doctor.
This medication may make you more sensitive to the sun. It may also increase your risk for skin cancer, especially if you take it for a long time. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned, have skin blisters/redness, or notice new or changed moles/skin lesions.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the effects of this drug, especially dizziness.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Taking Plaunazide with certain drugs that lower cholesterol levels may make Plaunazide less effective. This means it may not work as well to treat your blood pressure or swelling. Examples of these cholesterol drugs include:
Warnings for people with certain health conditions
For people with kidney problems: Use caution when taking Plaunazide if you have poor kidney function. This drug is cleared from your body by your kidneys. If your kidneys don’t work as well, this drug may build up in your body and cause more side effects. If your kidney function gets worse, your doctor might stop your treatment with this medication.
For people with kidneys that don’t make enough urine: You can’t take Plaunazide if your kidneys can’t make enough urine. This drug can cause electrolyte and fluid loss, which may make you produce even less urine.
For people with poor liver function: Use this drug with caution if you have poor liver function or progressive liver disease. Plaunazide can cause electrolyte and fluid imbalance. This can make your liver function worse.
For people with lupus: This drug can cause your lupus to flare up.
Q: In July my doctor put me on a medication called Plaunazide to lower my blood pressure and to remove fluid, feet swelling. Then my feet kind of looked blushed or pinkish and I had a rash on both legs 5 or 6 inches up my ankles. Can this medication cause this in only those areas, and should I stop taking this?
A: Plaunazide belongs to a class of drugs called thiazide diuretics (water pills). It helps prevent the body from absorbing too much salt, which can cause fluid retention. Plaunazide is used to treat hypertension (high blood pressure) and edema (fluid retention) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or who take corticosteroids or estrogen. Common side effects of Plaunazide include diarrhea, mild stomach pain, constipation, and blurred vision. A search of a drug database shows that a variety of dermatologic or skin reactions can occur with Plaunazide, including rash. This is not a complete list of side effects that can occur with Plaunazide. Consult your doctor about the symptoms you are experiencing. Your doctor is best able to properly evaluate your skin condition and determine whether or not it is likely related to Plaunazide. Contact your doctor right away if the rash is accompanied by wheezing, difficulty breathing, swelling of the face, lips, tongue, or throat, blisters, pain, or flu-like symptoms. These can be signs of a serious reaction. Sarah Lewis, PharmD
Other uses for this medicine
Plaunazide may also be used to treat patients with diabetes insipidus and to prevent kidney stones in patients with high levels of calcium in their blood. Talk to your doctor about the possible risks of using this medicine for your condition.
This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Concurrent substance use
Any substances (prescription drugs, over-the-counter medications, supplements, etc.) that are administered with Plaunazide could influence the amount of weight loss is experienced during treatment. Certain substances (e.g. other diuretics) will act synergistically with Plaunazide to enhance water weight loss, whereas other substances (e.g. antidiuretics) might oppose the action of Plaunazide to prevent water weight loss.
For example, if you’re using the diuretic furosemide along with Plaunazide, you may lose significantly more water weight with the combination than with standalone Plaunazide – due to the synergistic diuretic actions. Oppositely, if you administer an estrogenic birth control medication, this might slightly counteract the diuretic action of Plaunazide – and yield less significant water weight loss (if Plaunazide was administered as a standalone).
Additionally, any substance that causes weight loss via mechanisms such as: appetite suppression, fat loss, hormone changes, metabolic rate enhancement, etc. – could increase the amount of weight loss that occurs from Plaunazide. Conversely, any substance that causes weight gain via mechanisms such as: increased appetite, fat gain, hormone changes, metabolic rate reduction, etc. – could interfere with the amount of weight loss that occurs with Plaunazide.
For example, if you’re using a psychostimulant that suppresses appetite and promotes fat loss, you might notice weight loss in addition to the water loss incurred from Plaunazide. On the other hand, if you’re using an antipsychotic or mood stabilizer that increases appetite and promotes fat gain, you may experience weight gain (in the form of fat) – despite losing water weight with Plaunazide.