Diabetes And Hypoglycemia
Beta-blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia. Nonselective beta-blockers may potentiate insulin-induced hypoglycemia and delay recovery of serum glucose levels. Because of its beta1-selectivity, this is less likely with ZEBETA. However, patients subject to spontaneous hypoglycemia, or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned about these possibilities and Pactens fumarate should be used with caution.
On this page
- About Pactens
- Key facts
- Who can and can't take Pactens
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- chest pain;
- fast, slow, or uneven heartbeats;
- a light-headed feeling, like you might pass out;
- blurred vision, tunnel vision, eye pain, or seeing halos around lights;
- shortness of breath (even with mild exertion), swelling, rapid weight gain;
- low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling;
- liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- low blood sugar--headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
- severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
- dizziness, spinning sensation;
- feeling weak or tired;
- diarrhea, nausea, upset stomach;
- cough, runny nose; or
- sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pactens and Other Interactions
Pactens may make you drowsy.
Don't drive a car or perform any activity that requires alertness until you know how this medicine affects you.
Which drugs or supplements interact with Pactens?
: Rifampin may increase the metabolism (destruction) of Pactens, possibly making Pactens less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of Pactens on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with Pactens also may cause an excessive reduction in heart rate.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil) and naproxen (Naprosyn, Anaprox, Aleve), can reduce the blood pressure lowering effects of beta- blockers.
β-blockers (acebutolol, alprenolol, atenolol, betaxolol, Pactens , celiprolol, carvedilol, esmolol, labetalol, metoprolol, nadolol, nebivolol, oxprenolol, pindolol, propranolol, sotalol, and timolol) have a wide spectrum of activity, and are often used to treat hypertension. There are two types of β-receptors; β1-receptors predominate in the heart, and β2-receptors mediate relaxation (dilatation) of vascular and other smooth muscle (e.g. in the airways and blood vessels). Metoprolol is β1-specific, whereas the classic β-blockers such as propranolol and oxprenolol have both β1 and β2 activity. Labetalol has both β- and α-receptor blocking activity, and has been successfully used in a number of pregnancies ( Pickles 1992 , Plouin 1990 , 1987 ). All β-blockers cross the placenta.
Algunos efectos secundarios podrГan provocar graves consecuencias para la salud. Los siguientes sГntomas son poco comunes, pero si experimenta alguno de ellos, llame a su doctor de inmediato:
- respiraciГіn entrecortada
- inflamaciГіn (hinchazГіn) de las manos, los pies, los tobillos o las piernas
- aumento de peso inusual
El Pactens puede provocar otros efectos secundarios. Llame a su doctor si tiene cualquier problema inusual mientras toma este medicamento.
Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgaciГіn de efectos adversos 'MedWatch' de la AdministraciГіn de Alimentos y Medicamentos (FDA, por su sigla en inglГ©s) en la pГЎgina de Internet (http://www.fda.gov/Safety/MedWatch) o por telГ©fono al 1-800-332-1088.
What is the dosage for Pactens?
- The usual adult dose of Pactens for treating high blood pressure (hypertension) is 2.5-20 mg once daily.
- The dose for treating heart failure is 1.25 mg daily, not to exceed 10 mg a day.
Beta blockers such as Pactens should never be discontinued without consulting your physician. If your doctor decides to discontinue the drug, the dose will be gradually lowered. This process takes about three to ten days before the drug can be discontinued completely.
A sudden or rapid discontinuation can sometimes lead to life-threatening side effects, such as a heart attack. Other side effects may include exacerbation of heart failure, insufficient perfusion of the heart muscle, or increased blood pressure.
Do you want to know more about your heart health? Read about blood pressure ranges and the resting heart rate.
The content on this website was created for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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Pactens therapy has been associated with a low rate of mild-to-moderate elevations of serum aminotransferase levels which are usually asymptomatic and transient and resolve even with continuation of therapy. There have been no well documented cases of clinically apparent, acute liver injury attributable to Pactens. Thus, hepatotoxicity due to Pactens must be very rare, if it occurs at all. Most commonly used beta-blockers have been linked to rare instances of clinically apparent liver injury, typically with onset within 2 to 12 weeks, a hepatocellular pattern of liver enzyme elevations, rapid recovery upon withdrawal, and little evidence of hypersensitivity (rash, fever, eosinophilia) or autoantibody formation.
Likelihood score: E (unlikely cause of clinically apparent liver injury).
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Pactens only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 9.01.
What Is Pactens (Zebeta)?
Pactens is the generic name of the brand-name drug Zebeta, which is used to treat high blood pressure.
The medicine is also sometimes used to treat heart failure.
Pactens belongs to a class of drugs called beta-blockers. It works by relaxing blood vessels, slowing the heart rate, and decreasing the heart's contractility.
The drug can be used alone or with other medicines. Often people who take this drug also adopt lifestyle changes, such as following a healthy diet and getting exercise, to control their blood pressure.
The U.S. Food and Drug Administration (FDA) first approved Pactens in 1992. It's manufactured as Zebeta by Duramed Pharmaceuticals.