Noidouble tablets

Noidouble

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Noidouble?

The active ingredient of Noidouble brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Noidouble is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Noidouble include: pinpoint red spots on the skin; sore throat; unusual tiredness or weakness; breast pain; unusual dullness or feeling of sluggishness; Abdominal or stomach cramping, burning, or tenderness; weight gain.

How to Buy Noidouble tablets online?

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Lithium

Taking lithium with Noidouble can increase the effects of lithium. Your doctor may lower your dosage of lithium if you take these drugs together.

Rated Noidouble (Aldactone) for Acne Report

Updating my progress on Noidouble: I posted a 2 star rating 2 months in for cystic chin acne. Acne was getting severely worse and in new odd places on my face. Slowly increased from 25 to 100 mg. Improvement began 4 months in with 100 mg per day AND a time release minocycline for 2 months. Been off the minocycline for about a month now. Side effects are breast pain when period approaching and slightly shorter period cycle. Early on , I had severe facial dryness and had to use olive oil on my skin. Not so bad anymore with cereve pm moisturizer and retin-a only once a week. Currently my cystic acne feels cured after almost 6 months and I’m only dealing with small manageable pimples. My suggestion to girls suffering with cystic acne and reading these posts all the time like I was. is to start at a higher mg - and with a short round of antibiotic to get through the beginning. I think my 6 months of suffering could have been avoided. I wish I didn’t have to take a pill but too afraid of accutane and tired of hiding. I will repost if this is short lived due to the antibiotic round. Best wishes!

Other uses for this medicine

Noidouble also is used in combination with other medicines to treat precocious puberty (a condition causing children to enter puberty too soon, resulting in the development of sexual characteristics in girls usually younger than 8 years of age and in boys usually younger than 9 years of age) or myasthenia gravis (MG, a disease in which the nerves do not function properly and patients may experience weakness; numbness; loss of muscle coordination; and problems with vision, speech, and bladder control). Noidouble also may be used to treat certain female patients with abnormal facial hair. Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What Is Noidouble and How Does It Work?

Noidouble is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems.

Noidouble is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone).

Noidouble is known as a "water pill" (potassium-sparing diuretic).

Noidouble has also been used to treat excessive hair growth (hirsutism) in women with polycystic ovary disease.

Noidouble is available under the following different brand names: Aldactone.

What is Noidouble?

Noidouble is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Noidouble is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood).

Noidouble also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.

Noidouble is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.

Background

Noidouble (spir on oh lak' tone) is a competitive inhibitor of the mineralocorticoid receptor in the late distal tubule and collecting duct of the kidneys, which causes a decrease in sodium reabsorption and potassium excretion in the distal tubule. As a result, Noidouble promotes a sodium diuresis, but maintains body potassium levels. Noidouble is particularly helpful in edematous states caused or exacerbated by hyperaldosteronism, which is typical of the edema and ascites caused by cirrhosis. Because of its potassium-sparing actions, Noidouble is also used in combination with thiazide or loop diuretics in an attempt to prevent hypokalemia. Chronic low dose therapy with Noidouble has also been reported to improve survival in patients with heart failure after myocardial infarction. Noidouble was approved for use in the United States in 1960 and continues to be widely used. Noidouble is available in 25, 50, 75 and 100 mg tablets generically and under the brand name of Aldactone. Fixed combinations of Noidouble and hydrochlorothiazide are also available under the brand name Aldactizide. The typical dose of Noidouble is 25 mg one to three times daily initially, with modification of the dose based upon clinical efficacy and tolerance to maintenance doses of 75 to 450 mg daily. The major side effects of Noidouble are due to its antiandrogen-like effects and include hair growth and gynecomastia.


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