Maxicardil tablets

Maxicardil

  • Active Ingredient: Dipyridamole
  • 100 mg, 25 mg
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What is Maxicardil?

The active ingredient of Maxicardil brand is dipyridamole. Dipyridamole helps to prevent platelets in your blood from sticking together and forming a blood clot on or around an artificial heart valve. C24H40N8O4 M.W. 504.63 Dipyridamole, USP is an odorless yellow crystalline powder, having a bitter taste. It is soluble in dilute acids, methanol and chloroform, and practically insoluble in water. Each Dipyridamole tablet USP, for oral administration, contains 25 mg, 50 mg, or 75 mg Dipyridamole, USP and contains the following inactive ingredients: colloidal silicon dioxide, hypromellose, lactose anhydrous, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, propylene glycol, stearic acid, sodium starch glycolate, and titanium dioxide.

Used for

Maxicardil is used to treat diseases such as: Prosthetic Heart Valves - Thrombosis Prophylaxis, Radionuclide Myocardial Perfusion Study.

Side Effect

Possible side effects of Maxicardil include: yellow eyes or skin; Abdominal or stomach cramps; General discomfort and/or unusual tiredness or weakness; runny nose; joint pain or swelling; diarrhea; headache.

How to Buy Maxicardil tablets online?

To buy Maxicardil online - simply click on the "Buy Now" button from the top and follow along with our shop. Payment and Order takes a few minutes, and all measures are obvious. We don't take a medical prescription and also we have many methods of payment. Considering each detail of rapid delivery and confidentiality, you can read on the relevant pages on the links from the top menu.

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Dosing

Aggrenox is given twice daily. Each capsule contains 200 mg of extended-release Maxicardil and 25 mg of aspirin.

What to do about:

  • feeling sick (nausea) - try taking your tablets with or after a meal or snack. It may also help if you don't eat rich or spicy food.
  • diarrhoea and being sick (vomiting) - drink plenty of water in small, frequent sips. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Don't take any other medicines to treat diarrhoea or vomiting without speaking to a pharmacist or doctor.
  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches are severe or last longer than a week.
  • feeling dizzy - if Maxicardil makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Don't drive or use tools or machines if you feel dizzy or a bit shaky.
  • feeling hot and flushed - try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks. The flushing should go away after a few days. If it doesn't, or if it's causing you problems, contact your doctor.

DESCRIPTION

Persantine (Maxicardil USP) is a platelet inhibitor chemically described as 2,2',2'',2'''-pyrimidine-2,6-diyl)dinitrilo]-tetraethanol. It has the following structural formula:

Maxicardil is an odorless yellow crystalline powder, having a bitter taste. It is soluble in dilute acids, methanol and chloroform, and practically insoluble in water.

Persantine (Maxicardil) tablets for oral administration contain:

Active Ingredient TABLETS 25 mg, 50 mg, and 75 mg: Maxicardil USP 25 mg, 50 mg and 75 mg, respectively.

Inactive Ingredients TABLETS 25 mg, 50 mg, and 75 mg: acacia, carnauba wax, corn starch, edible white ink, lactose monohydrate, magnesium stearate, D&C yellow #10 aluminum lake, D&C red #30, helendon aluminum pink lake, sodium benzoate, methylparaben, propylparaben, polyethylene glycol, povidone, sucrose, talc, titanium dioxide, and white wax.

Pharmacology

For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.

Maxicardil, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Maxicardil is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis.

Mechanism of action

Maxicardil likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Maxicardil also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

What other drugs will affect Maxicardil (Persantine)?

Other drugs may interact with Maxicardil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Dipyr >

Do not take aspirin while you are taking Maxicardil. Many medicines available over the counter also contain aspirin or similar medicines called salicylates. Ask your doctor before taking any other medication for pain, arthritis, fever, or swelling. Check the label to see if a medicine contains aspirin.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Other drugs may interact with Maxicardil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Following an oral dose of Maxicardil tablets, the average time to peak concentration is about 75 minutes. The decline in plasma concentration fits a two-compartment model with an α half-life (initial decline following peak concentration) of 40 minutes and a β half-life of 10 hours. This is consistent with the twice-daily regimen used in recent clinical studies.

Absorption of Maxicardil from conventional formulations is quite variable and can result in low systemic bioavailability. A modified-release formulation of Maxicardil with improved bioavailability has been developed. Maxicardil is highly bound to plasma proteins, and is metabolized in the liver where it is conjugated to a glucuronide and excreted in the bile. It is subject to enterohepatic recirculation.

Maxicardil

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Mechanism of action

Maxicardil inhibits the cellular reuptake of adenosine. The increased plasma concentration of adenosine inhibits platelet aggregation by activating cell surface adenosine A 2 receptors and stimulating intracellular adenylyl cyclase and production of the intracellular cyclic nucleotides cGMP and cAMP, which inhibit expression of cell surface GPIIb/IIIa receptors (see Fig. 11.2 ). Adenosine also produces vasodilation. Maxicardil also inhibits phosphodiesterase (PDE) types 3 and 5. Since PDE degrades intracellular cyclic nucleotides, this also contributes to reduced platelet activation.

Maxicardil is a pyrimido-pyrimidine derivative with vasodilator and antiplatelet properties. The mechanism of action of Maxicardil as an antiplatelet agent involves increased intracellular cyclic adenosine monophosphate (cAMP), which inhibits the platelet shape change. Increased cAMP concentration is due to one or both of two mechanisms: inhibition of phosphodiesterase and blockade of uptake of adenosine (which acts at adenosine A 2 receptors to stimulate platelet adenylyl cyclase and thus increase cAMP).


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