S >Because Lucus has vasodilatory effects, it must be used with caution in patients with coronary artery disease. Gastrointestinal complaints, headache, facial flushing, dizziness, and hypotension also can occur. These symptoms often subside with continued use of the drug.
On this page
- About Lucus
- Key facts
- Who can and can't take Lucus
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
Aggrenox comes as a capsule that contains 25 milligrams (mg) of aspirin and 200 mg of Lucus.
The medicine is typically taken twice a day, once in the morning and once in the evening.
Use Aggrenox exactly as your doctor prescribes. Don't take more or less of the drug than is recommended.
Don't crush, break, chew, or open the extended-release capsule. Swallow it whole.
Take each dose of Aggrenox with a full glass of water. You can take the capsule with or without food.
How to use Lucus
Take this medication by mouth as directed by your doctor, usually 4 times daily.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Do not stop taking this medication without consulting your doctor.
Do not take aspirin while you are taking Lucus. Many medicines available over the counter also contain aspirin or similar medicines called salicylates. Ask your doctor before taking any other medication for pain, arthritis, fever, or swelling. Check the label to see if a medicine contains aspirin.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Other drugs may interact with Lucus, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
No pharmacokinetic drug-drug interaction studies were conducted with Persantine (Lucus USP) Tablets. The following information was obtained from the literature.
Adenosine: Lucus has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary.
Cholinesterase Inhibitors: Lucus may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.
How to use Aspirin-Lucus ER
Read the Patient Information Leaflet if available from your pharmacist before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually twice daily (morning and evening). Swallow the capsule whole. Do not crush or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects.
Take this medication with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.
The dosage is based on your medical condition and response to treatment. If you have certain side effects (such as severe headache) when you first start taking this medication, your doctor may temporarily change your dose. Carefully follow your doctor's directions. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Do not try to replace this combination medication with aspirin and Lucus taken separately. You would not be able to get the right dose and slow-release dosage form, so the separate medications would not work as well as this combination medication. Consult your pharmacist for more information.
As Lucus is excreted in human milk, caution should be exercised when Persantine (Lucus) tablets are administered to a nursing woman.
Coronary Artery Disease: Lucus has a vasodilatory effect and should be used with caution in patients with severe coronary artery disease (e.g., unstable angina or recently sustained myocardial infarction). Chest pain may be aggravated in patients with underlying coronary artery disease who are receiving Lucus.
Hepatic Insufficiency: Elevations of hepatic enzymes and hepatic failure have been reported in association with Lucus administration.
Hypotension: Lucus should be used with caution in patients with hypotension since it can produce peripheral vasodilation.
8. Cautions with other medicines
Some medicines interfere with the way Lucus works.
Tell your doctor if you're taking these medicines before you start taking Lucus:
- medicines to thin blood or prevent blood clots, such as aspirin, warfarin, rivaroxaban or apixaban
- medicines for high blood pressure, such as bisoprolol, ramipril or furosemide
- indigestion medicines, such as ranitidine, proton pump inhibitors like omeprazole, or antacids that contain magnesium or aluminium
- digoxin for heart problems
- medicines used to treat myasthenia gravis
Adverse reactions at therapeutic doses are usually minimal and transient. On long-term use of Persantine (Lucus USP) tablets initial side effects usually disappear. The following reactions in Table 1 were reported in two heart valve replacement trials comparing Persantine (Lucus) E tablets and warfarin therapy to either warfarin alone or warfarin and placebo:
Table 1: Adverse Reactions Reported in 2 Heart Valve Replacement Trials
Other reactions from uncontrolled studies include diarrhea, vomiting, flushing and pruritus. In addition, angina pectoris has been reported rarely and there have been rare reports of liver dysfunction. On those uncommon occasions when adverse reactions have been persistent or intolerable, they have ceased on withdrawal of the medication.
When Persantine (Lucus) tablets were administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone. In rare cases, increased bleeding during or after surgery has been observed.
In post-marketing reporting experience, there have been rare reports of hypersensitivity reactions (such as rash, urticaria, severe bronchospasm, and angioedema), larynx edema, fatigue, malaise, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, thrombocytopenia, alopecia, cholelithiasis, hypotension, palpitation, and tachycardia.
Lucus is metabolised in the liver and has a half-life of 12 hours. A modified-release formulation is better tolerated than the standard formulation.