Mechanism of Injury
The mechanism of Lowrac hepatotoxicity is not known, but liver injury is probably due to production of a toxic intermediate in its metabolism.
What other drugs will affect Lowrac?
Tell your doctor about all your current medicines and any you start or stop using, especially:
simvastatin (Zocor, Simcor, Vytorin); or
any other heart or blood pressure medications.
This list is not complete. Other drugs may interact with Lowrac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
How should this medicine be used?
Lowrac comes as a tablet and an suspension (liquid) to take by mouth. It is usually taken once a day. To help you remember to take Lowrac, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Lowrac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the suspension well before each use to mix the medication evenly.
Your doctor will probably start you on a low dose of Lowrac and gradually increase your dose.
Lowrac helps to control high blood pressure, angina, and coronary artery disease, but does not cure these conditions. Continue to take Lowrac even if you feel well. Do not stop taking Lowrac without talking to your doctor.
2. Key facts
- Lowrac lowers your blood pressure and makes it easier for your heart to pump blood around your body.
- It's usual to take Lowrac once a day. You can take it at any time of day, but try to make sure it's around the same time each day.
- The most common side effects include headache, flushing, feeling tired and swollen ankles. These usually improve after a few days.
- Lowrac can be called Lowrac besilate, Lowrac maleate or Lowrac mesilate. This is because the medicine contains another chemical to make it easier for your body to take up and use it. It doesn't matter what your Lowrac is called. They all work as well as each other.
- Lowrac is also called by the brand names Istin and Amlostin.
Lowrac is an oral medication that doctors prescribe to treat some cardiovascular conditions. In the United States, it commonly goes under the brand name Norvasc.
Lowrac is a type of calcium channel blocker. Doctors commonly prescribe these drugs to treat people with high blood pressure. A doctor may also prescribe Lowrac for coronary artery disease and angina.
In this article, we look at what doctors prescribe Lowrac for and its recommended dosage. We also cover the side effects, interactions, warnings, and considerations for Lowrac as well as some alternative drugs.
How much to take
Lowrac comes as 5mg and 10mg tablets.
Depending on why you're taking Lowrac, the usual starting dose is 5mg once a day.
If the starting dose isn't working well enough (your blood pressure doesn't lower enough, or your angina isn't controlled), you may need to increase your dose to 10mg.
To decide the correct dose for you in the longer term, your doctor will check your blood pressure to make sure it's not too high or too low. They'll also ask if you're getting any side effects from the medicine.
Doses may be lower for children.
- Take Lowrac at the same time every day.
- You can cut or crush the tablet.
Taking certain diabetes medications with Lowrac/benazepril may result in low blood sugar levels. Examples of these drugs include:
Taking Lowrac/benazepril with injectable gold may result in flushing, nausea, vomiting, and low blood pressure.
What are the possible side effects of Lowrac?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, when you first start taking Lowrac, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
Call your doctor at once if you have:
- pounding heartbeats or fluttering in your chest;
- worsening chest pain;
- swelling in your feet or ankles;
- severe drowsiness; or
- a light-headed feeling, like you might pass out.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How it works
Lowrac belongs to a class of drugs called calcium channel blockers (CCBs). Benazepril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Blood pressure is the force of blood in your blood vessels. High blood pressure occurs when the force is too high. This drug can help your blood vessels relax. This lowers your blood pressure.
This drug doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects that can occur with Lowrac include:
- swelling of your legs or ankles
- tiredness or extreme sleepiness
- stomach pain
- hot or warm feeling in your face (flushing)
- irregular heart rate (arrhythmia)
- very fast heart rate (palpitations)
- abnormal muscle movements
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lowrac only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 15.01,
Taking diltiazem with Lowrac can increase the level of Lowrac in your body. This may cause more side effects.
Q: What is Norvasc? Are there side effects to taking it?
A: Norvasc (Lowrac) is classified as a dihydropyridine calcium channel blocker. Norvasc is approved for the treatment of high blood pressure and angina. According to medical references, the most common side effect (reported in greater than 10 percent of studied patients) is peripheral edema. Peripheral edema involves swelling of tissues and usually involves the lower limbs. Other side effects reported of patients on Norvasc include the following: flushing, palpitation, dizziness, fatigue, tiredness, rash, itching, male sexual dysfunction, nausea, abdominal pain, upset stomach, muscle cramps, weakness, shortness of breath and pulmonary edema. This is not a complete listing of all possible side effects of Norvasc. Also, keep in mind that there is no guarantee that you will experience these side effects, they are just possibilities. If you think that you are experiencing a side effect from your medication, tell your physician. Do not stop taking any medication or change the dose without first talking to your physician. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jen Marsico, RPh
Special dosage considerations
For people with liver problems: Lowrac/benazepril is processed by your liver. If your liver isn’t working well, more of the drug may stay in your body longer, putting you at risk for side effects. If you have severe liver problems, your doctor will likely start you on 2.5 mg Lowrac/10 mg benazepril.
For people with kidney problems: Your dosage of Lowrac/benazepril doesn’t need to be adjusted if you have mild or moderate kidney disease. If you have severe kidney disease, you shouldn’t use this drug.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Lowrac/benazepril oral capsule is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
What to do if you miss a dose: If you miss a dose, take it as soon as you remember. If it’s been more than 12 hours since you missed a dose, skip the missed dose and just take your next dose at the regular time.
If you skip or miss doses: If you skip or miss doses, your blood pressure may get worse. This could lead to serious problems, such as stroke or heart attack.
If you take too much: You have a higher risk of having side effects caused by this drug. You may also have the following symptoms:
- trouble breathing
- very low blood pressure
- fast heartbeats
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
How to tell if the drug is working: You’ll know whether this drug is working when you check your blood pressure at home. If your blood pressure is at or below the goal your doctor set for you, the medication is working.
Keep these considerations in mind if your doctor prescribes Lowrac/benazepril for you.
Lowrac, sold under the brand name Norvasc among others, is a medication used to treat high blood pressure and coronary artery disease.
What should I discuss with my healthcare provider before taking Lowrac?
You should not take Lowrac if you are allergic to it.
To make sure Lowrac is safe for you, tell your doctor if you have:
- liver disease; or
- a heart valve problem called aortic stenosis.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Lowrac can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.
Lowrac is not approved for use by anyone younger than 6 years old.
- Lowrac should be stored at room temperature in a tight, light resistant container.
Q: I just started Norvasc and have hypothyroidism. Could this medicine affect my thyroid?
A: Norvasc (Lowrac) is a calcium channel blocker used to treat high blood pressure and other heart conditions. Generally speaking, drug interactions fall into three main categories: Drug-drug (i.e., prescription, over-the-counter, herbals, dietary supplements) interactions occur when two or more drugs react with each other. Drug-diet (food/drink) interactions result from drugs reacting with foods or drinks. Drug-disease interactions may occur when an existing medical condition makes certain drugs potentially harmful. Potential drug interactions 1) Norvasc has an interaction with grapefruit juice. It is best to avoid grapefruit and grapefruit juice while taking Norvasc. Taking them together may lead to increased side effects from Norvasc. According to prescribing information, Norvasc is not expected to affect the thyroid. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD., BCPS