Which drugs or supplements interact with Losarb?
- Losarb reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of Losarb. Blood sugar levels can be elevated by Losarb, necessitating adjustment in the doses of medications that are used for treating diabetes.
- Combining Losarb with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium (hypokalemia) can increase the toxicity of digoxin (Lanoxin).
- Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to Losarb and reduce its absorption from the gastrointestinal tract by 43% to 85%.
How it works
Valsartan belongs to a class of drugs called angiotensin II receptor blockers. Losarb belongs to a class of drugs called diuretics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Valsartan blocks the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. This helps to relax and widen your blood vessels, which lowers your blood pressure.
Losarb may work by removing sodium (salt) and water from your body. This helps reduce your blood pressure.
Valsartan/Losarb oral tablet may cause drowsiness. It can also cause other side effects.
Q: I was taking Benicar HCT, and the urologist put me on Cordura and asked that I stop the HCT portion of the Benicar. Why would I need to get off the HCT?
A: HCT (Losarb) belongs to a class of drugs called thiazide diuretics (water pills). It helps prevent your body from absorbing too much salt, which can cause fluid retention. Losarb treats edema (fluid retention) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. It is also used to treat hypertension (high blood pressure). Common side effects of Losarb include diarrhea, mild stomach pain, constipation, and blurred vision. This is not a complete list of side effects that can occur with Losarb. There are many reasons that your doctor may have had to advise you to stop taking Losarb. These possibilities can include electrolyte imbalances, changes in kidney function, fluid imbalances, hypotension (low blood pressure), and other medical conditions. Your doctor or health care provider is best able to guide your treatment decisions based on your specific circumstances. Consult your urologist to find out the specific reason that Losarb was stopped. Do not stop or change the amount of your current medications without talking to your doctor first. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, RPh, PharmD
Does Losarb cause weight loss? (If so, how much?)
Yes. All data from trials in which the effect of Losarb on body weight was evaluated suggest that the medication causes clinically significant weight loss as a side effect. The fact that Losarb causes weight loss shouldn’t be very surprising given that it functions as a diuretic – causing the body to excrete sodium and water stores.
Q: What are the side effects of Losarb?
A: Losarb (Microzide, HydroDIURIL), commonly referred to as HCTZ, is classified as a thiazide diuretic (water pill) which helps prevent the body from absorbing an excess amount of salt, which causes fluid retention. HCTZ is used to treat edema (fluid retention) in patients with congestive heart failure, cirrhosis of the liver, and kidney disorders. HCTZ may also be used to treat steroid or estrogen induced edema. HCTZ is also indicated in the treatment of hypertension (high blood pressure). Some of the side effects possible with treatment with HCTZ include diarrhea, mild stomach pain, constipation and blurred vision. These are not all of the side effects that may occur with HCTZ treatment. If you experience anything unusual or bothersome while being treated with HCTZ, it is important to consult with your health care provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Beth Isaac, PharmD
Losarb and Overdose
Signs of an overdose may include:
- Dry mouth
- Muscle pain/weakness
In the event of an accidental overdose, call 911 immediately or contact a poison control center at 1-800-222-1222.
Rated Losarb (Microzide) for Hypertension Report
Wow, I have been taking 12.5 Losarb for almost 10 years. Every once in a while I tried to stop, but good old BP just went back up. I don't think I have ever felt any side effect with this drug. I always thought it was one of the milder blood pressure drugs out there. I just discovered my renal artery was 90% plus blocked, and had a stent put in. So far that is doing good in lowering BP, but really, I have absolutely no problem taking this medication.
Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in increased risk of cholesterol gallstone formation. Reports of bowel strictures associated with thiazide ingestion were reported in the 1960s although these patients were on a combination Losarb-potassium product.
Frequency not reported: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, acute cholecystitis
What other drugs will affect Losarb?
Taking this medicine with other drugs that make you light-headed can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
insulin or oral diabetes medicine;
other blood pressure medications;
steroid medicine; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with Losarb, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
You should not use Losarb if you are unable to urinate.
Before using Losarb, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin.
Avoid drinking alcohol, which can increase some of the side effects of this medicine.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
There are many other drugs that can interact with Losarb. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
If you are being treated for high blood pressure, keep using Losarb even if you feel fine. High blood pressure often has no symptoms.
Before taking Losarb, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, kidney disease, liver disease, lupus, skin cancer.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Severe sweating, diarrhea, or vomiting can increase the risk for a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.
If you have diabetes, Losarb may affect your blood sugar. Check your blood sugar regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
This drug may decrease your potassium levels. Ask your doctor about foods high in potassium (such as bananas, orange juice) or about using a salt substitute containing potassium. A potassium supplement may be prescribed by your doctor.
This medication may make you more sensitive to the sun. It may also increase your risk for skin cancer, especially if you take it for a long time. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned, have skin blisters/redness, or notice new or changed moles/skin lesions.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the effects of this drug, especially dizziness.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
More common side effects
The more common side effects that can occur with valsartan/Losarb include:
- nose and throat infections
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
In general, lithium shouldn’t be taken with Losarb. That’s because Losarb slows the clearance of lithium from your body. This increases your risk of high levels of lithium in your body, which can cause dangerous side effects.