Lopiten tablets

Lopiten

  • Active Ingredient: Amlodipine
  • 10 mg, 5 mg, 2.5 mg
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What is Lopiten?

The active ingredient of Lopiten brand is amlodipine. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

Used for

Lopiten is used to treat diseases such as: Angina, Coronary Artery Disease, Heart Failure, High Blood Pressure, Migraine Prevention, Raynaud's Syndrome.

Side Effect

Possible side effects of Lopiten include: bleeding gums; hair loss or thinning of the hair; change in color of the treated skin; painful or difficult urination; fainting; red, irritated eyes.

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Hepatotoxicity

Chronic therapy with Lopiten is associated with a low rate of serum enzyme elevations at rates that are similar to matched control populations. The enzyme elevations are usually mild, transient and asymptomatic and may resolve even during continued therapy. Clinically apparent liver injury from Lopiten is rare and described only in isolated case reports. In the few idiosyncratic cases reported, the latency period to onset of liver injury was usually 4 to 12 weeks, but examples with prolonged latency have also been published (10 months and several years). The latency period is shorter with recurrence on reexposure, including several instances of recurrence after liver injury due to other calcium channel blockers. The pattern of serum enzyme elevations is usually mixed or cholestatic. Rash, fever and eosinophilia have not been described and autoantibodies are not typical.

Likelihood score: C (probable but rare cause of clinically apparent liver injury).

More common side effects

The more common side effects that can occur with Lopiten include:

  • swelling of your legs or ankles
  • tiredness or extreme sleepiness
  • stomach pain
  • nausea
  • dizziness
  • hot or warm feeling in your face (flushing)
  • irregular heart rate (arrhythmia)
  • very fast heart rate (palpitations)
  • abnormal muscle movements
  • tremors

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Serious allergic reaction. Symptoms can include:
    • swelling of your face, eyelids, lips, tongue, or throat
    • trouble swallowing
    • wheezing or other breathing problems
  • feeling faint or dizzy, especially when you stand up
  • tiredness
  • lightheadedness
  • nausea
  • tiredness
  • weakness
  • itching
  • yellowing of your skin or the whites of your eyes
  • pain in your upper right abdomen
  • fever
  • cough
  • sore throat
  • runny or stuffy nose
  • body aches
  • chills
  • tiredness
  • swelling, especially of your hands, feet, or ankles
  • shortness of breath
  • Chest pain and heart attack
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Lopiten/benazepril oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Lopiten/benazepril are listed below.

    ANNOTATED BIBLIOGRAPHY

    References updated: 01 March 2016

    1800 controls reported similar rate of ALT elevations with Lopiten as with hydrochlorthiazine , and no serious liver toxicity).

    50,000 liver transplants reported to UNOS between 1990 and 2002, 270 were done for drug induced acute liver failure, but none were attributed to a calcium channel blocker).

    • Lopiten should be stored at room temperature in a tight, light resistant container.

    Diabetes medications

    Taking certain diabetes medications with Lopiten/benazepril may result in low blood sugar levels. Examples of these drugs include:

    • insulin
    • metformin
    • glimepiride
    • pioglitazone
    • sitagliptin

    Taking Lopiten/benazepril with injectable gold may result in flushing, nausea, vomiting, and low blood pressure.

    How it works

    Lopiten belongs to a class of drugs called calcium channel blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

    Lopiten blocks calcium from entering certain tissues and arteries. This makes it easier for them to relax so that blood can flow more easily to your heart. This in turn helps lower your blood pressure, and reduces your risk of heart attack or stroke. If you’re taking Lopiten for chest pain, this drug reduces your risk of hospitalization and surgeries due to chest pain.

    Lopiten oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Lopiten are listed below.

    What is Lopiten?

    Lopiten is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

    Lopiten is used to treat chest pain (angina) and other conditions caused by coronary artery disease.

    Lopiten is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

    Lopiten is for use in adults and children who are at least 6 years old.

    Lopiten may also be used for purposes not listed in this medication guide.

    Background

    Lopiten (am loe' di peen) belongs to the dihydropyridine class of calcium channel blockers and is used in the treatment of both hypertension and angina pectoris. Like other calcium channel blockers, Lopiten acts by blocking the influx of calcium ions into vascular smooth muscle and cardiac muscle cells during membrane depolarization. This action causes relaxation of vascular and arterial smooth muscle cells, resulting in arterial vasodilation and a decrease in cardiac work and oxygen consumption. Lopiten was approved in the United States in 1992 and it remains in wide use, with several million prescriptions filled yearly. Current indications include hypertension and coronary artery disease (angina pectoris). Lopiten is available generically and under the brand name of Norvasc. Tablet strengths include 2.5, 5, and 10 mg. The recommended dose in adults is 2.5 to 10 mg once daily, usually starting with the lowest dose. Chronic therapy is typical. Recently, multiple fixed dose combinations of Lopiten with other agents have become available including Lopiten (5 or 10 mg) with aliskiren (150 or 300 mg: Tekamlo), aliskiren with hydrochlorothiazide (12.5 and 25 mg: Amturnide), atorvastatin (10, 20, 40 or 80 mg: Caduet and generic), benzapril (10, 20 or 40 mg: Lotrel, Amlobenz, and generic), benzapril and hydrochlorothiazide (12.5 and 25 mg: Tribenzor), olmesaran (20 and 40 mg: Azor), and telmisartan (40 or 80 mg: Twynsta), valsartan (160 and 320 mg: Exforge) and valsartan with hydrochlorothiazide (25 mg: Exforge HCT). Like most calcium channel blockers, Lopiten is generally well tolerated. Side effects are largely due to the vasodilating activities and can include headache, flushing, dizziness, fatigue, nausea, diarrhea, palpitations, peripheral edema and rash.

    What is Lopiten?

    Lopiten is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

    Lopiten is used to treat chest pain (angina) and other conditions caused by coronary artery disease.

    Lopiten is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

    Lopiten is for use in adults and children who are at least 6 years old.


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