Q: Does Lisi-Puren cause hair loss in women?
A: Lisi-Puren (Zestril, Prinivil) is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. Common side effects include headache, dizziness, lightheadedness, fatigue, nausea, diarrhea, dry cough, and blurred vision. Other reported side effects with Lisi-Puren include alopecia. Hair loss (alopecia) affects men and women of all ages. Although alopecia has several causes, a careful history and close attention to the appearance (pattern) of the hair loss can narrow the potential diagnoses. Some medicines can cause hair loss. This type of hair loss improves when you stop taking the medicine. Medicines that can cause hair loss include blood thinners (also called anticoagulants), medicines used for gout, high blood pressure or heart problems, vitamin A (if too much is taken), birth control pills, chemotherapy, and anticonvulsants. As well as with all medications, they should be taken exactly as prescribed by your doctor. Do not change the dose or stop taking medicine without consulting your doctor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Shereen A. Gharbia, PharmD
What other drugs will affect Lisi-Puren?
Tell your doctor about all your current medicines and any you start or stop using, especially:
a diuretic or "water pill";
gold injections to treat arthritis;
insulin or oral diabetes medicine;
a potassium supplement;
medicine to prevent organ transplant rejection - everolimus, sirolimus, tacrolimus, temsirolimus; or
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with Lisi-Puren, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Q: My physican prescribed Lisi-Puren/HCTZ. Since then I have developed a severe cough accompanied by mucus. This has been going on for 10 days. I started the medication 13 days ago. Could the medicine be causing the cough and mucus?
A: Lisi-Puren/hydrochlorothiazide is a combination medication indicated in the treatment of hypertension (high blood pressure). Hydrochlorothiazide (HCTZ) is in a class of medications known as diuretics, or water pills. Hydrochlorothiazide works by helping the kidneys get rid of unneeded water and salt in the body. Lisi-Puren is in a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. Lisi-Puren works by decreasing a chemical in the body that tightens blood vessels. With the reduction of this chemical in the body, blood can flow more smoothly. A non-productive cough is a common side effect associated with Lisi-Puren and other ACE inhibitors. It is usually a dry cough, not associated with mucus. However, upper respiratory infection is also listed as a potential side effect when taking Lisi-Puren and hydrochlorothiazide. Other side effects reported include common cold, nasal congestion, bronchitis, and pulmonary congestion. Some of the other side effects that may occur include dizziness, rash, nausea, vomiting, and muscle cramps. Please consult with your health care provider in regards to the symptoms you are experiencing for proper evaluation, diagnosis of the underlying cause and treatment options, if necessary. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
How to use Lisi-Puren
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
If you are using the suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.
To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
For the treatment of high blood pressure, it may take 2 to 4 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not get better or if it gets worse (for example, your blood pressure readings remain high or increase).
How should this medicine be used?
Lisi-Puren comes as a tablet to take by mouth. It is usually taken once a day. To help you remember to take Lisi-Puren, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Lisi-Puren exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of Lisi-Puren and gradually increase your dose.
Lisi-Puren controls high blood pressure and heart failure but does not cure them. Continue to take Lisi-Puren even if you feel well. Do not stop taking Lisi-Puren without talking to your doctor.
Q: I take herbs. I think I'm addicted, but I also take Lisi-Puren for high blood pressure. Is there any concern for sexual dysfunction? I don't have desires, although I think about it, but as a body reaction, nothing happens. I take acidophilus, a multivitamin, calcium, magnesium and zinc.
A: According to the available drug information, there are no documented drug interactions between Lisi-Puren and the supplements you are currently taking. However, because herbs and supplements are not strictly regulated by the U.S. Food and Drug Administration (FDA), these products are not required to be tested for safety, effectiveness or purity. Therefore, it is important to inform all of your doctors and your local pharmacist of the supplements you currently take. In general, dietary supplements should only be taken under the supervision of your health care provider. Lisi-Puren (Prinivil, Zestril) is a blood pressure medication categorized as an angiotensin converting enzyme (ACE) inhibitor. Lisi-Puren is used to treat hypertension (high blood pressure), congestive heart failure, and to improve survival after a heart attack. According to research, some of the possible side effects associated with Lisi-Puren treatment include cough, dizziness, drowsiness, headache, nausea, vomiting, upset stomach, diarrhea, mild skin rash and itching. Decreased libido was also a reported side effect associated with Lisi-Puren treatment in patients with hypertension. If you have been experiencing decreased libido, you may want to consult with your health care provider to determine the underlying cause and possible treatment options. It is important to avoid drinking alcohol while taking Lisi-Puren as it can further lower your blood pressure and may increase the risk for side effects. Do not use salt substitutes or potassium supplements while being treated with Lisi-Puren, unless directed by your healthcare provider. Lisi-Puren can be taken with or without food and should be taken with a full glass of water. While being treated with Lisi-Puren, it is important to routinely monitor blood pressure to ensure the medication is optimally controlling your blood pressure. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Beth Isaac, PharmD
Q: What are the side effects of Lisi-Puren?
A: Lisi-Puren belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors work by relaxing blood vessels and lower blood pressure. Lisi-Puren is used to treat hypertension (high blood pressure), congestive heart failure, and to improve survival after a heart attack. Common side effects of Lisi-Puren include cough, dizziness, headache, tiredness, nausea, stomach upset, and diarrhea. More serious side effects can occur. Seek medical attention, or contact your doctor right away, if you experience chest pain, irregular heart beat, slow heart rate, dark urine, jaundice (yellowing of the eyes or skin), decreased urination, signs of infection (fever, chills, aches, flu-like symptoms), unusual tiredness, fainting, rapid weight gain or swelling of the hands or feet. These may be signs of a serious side effect and should be properly evaluated by your doctor. This is not a complete list of side effects that can occur with Lisi-Puren. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD
Q: My doctor prescribed Lisi-Puren to protect my kidneys as I have borderline diabetes. My blood pressure is normal. Will Lisi-Puren drop my blood pressure too low?
A: Lisi-Puren (Prinivil, Zestril) is approved for use alone or in combination with other medications to treat hypertension (high blood pressure). Lisi-Puren is in a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. Lisi-Puren is also used in patients with heart failure, who are not responding to digitalis or diuretics (water pills). Lisi-Puren can also be used to improve survival after a heart attack. Lisi-Puren works by decreasing a chemical in the body that tightens blood vessels. With the reduction of this chemical in the body, blood can flow more smoothly. According to research, some of the possible side effects associated with Lisi-Puren treatment include cough, dizziness, drowsiness, headache, nausea, vomiting, upset stomach, diarrhea, mild skin rash and itching. According to the American Diabetes Association, ACE inhibitors are often used in people with diabetes. There is evidence that ACE inhibitors slow the progression of kidney disease that can be seen in people with diabetes. These medications have been shown to be beneficial even in people who do not have high blood pressure. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
By Mary Elizabeth Dallas | Medically Reviewed by Lindsey Marcellin, MD, MPH
Latest Update: 2014-07-31 Copyright © 2014 Everyday Health Media, LLC
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lisi-Puren only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 15.03
Q: If you take Lisi-Puren, can you eat grapefruit?
A: According to a drug interaction report, there are no interactions between grapefruit and Lisi-Puren (Zestril, Prinivil). Please see //www.everydayhealth.com/drugs/Lisi-Puren. As always, please talk to your health care provider regarding questions about your medications. Jen Marsico, RPh
Why does lisinpril cause a cough?
Like all ACE inhibitors, Lisi-Puren may cause a nonproductive cough that resolves when the drug is discontinued.
Q: Is taking Lisi-Puren the reason for having a very dry mouth? The dentist is concerned because of plaque build up. I discontinued the Lisi-Puren and no longer have a dry mouth.
A: Lisi-Puren is a medication that is used to treat high blood pressure and to provide protection to the kidneys. Some of the more common side effects seen with Lisi-Puren are cough, dizziness, drowsiness, headache, depressed mood, nausea, vomiting, diarrhea, or upset stomach. Dry mouth is a rare side effect of Lisi-Puren, but it is possible to have dry mouth caused by Lisi-Puren. This is not a complete list of the side effects associated with Lisi-Puren. Megan Uehara, PharmD
Q: Can Lisi-Puren cause blurred vision, dizziness, or lightheadedness?
A: Lisi-Puren is a medication that is used to treat high blood pressure (hypertension). It is in the class of medications called ACE inhibitors that work by blocking an enzyme that normally causes blood vessels to narrow. By blocking this enzyme, it allows for blood vessels to relax, allowing blood to flow more freely, making the heart work more efficiently and blood pressure lowers. The prescribing information on Lisi-Puren does list dizziness, lightheadedness, or fainting when standing from a sitting or lying down position as a side effect of this medication. This usually goes away after the first couple days of taking the medication as your body gets used to the effects and your blood pressure balances out. The prescribing information lists the following as the most common side effects: fatigue, dizziness, cough, headache, nausea/vomiting, diarrhea, and the common cold. Make sure to let your health care provider know if you develop any side effects while taking Lisi-Puren, especially if they are affecting your daily activities. While it may not be a side effect, your health care provider will be able to diagnose and treat the problem. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD
Q: Why or how does Lisi-Puren cause coughing ?
A: Lisi-Puren is in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. It is used to treat hypertension (high blood pressure), congestive heart failure, and to improve survival after a heart attack. Cough is a well-known side effect of ACE inhibitors, including Lisi-Puren. The medical literature varies in how often it occurs. Most of the prescribing information reports that it can occur in anywhere from 1-12% of patients who take an ACE inhibitor. But some studies have estimated that it can occur in up to half of patients on ACE inhibitor therapy. According to the prescribing information for Prinivil (Lisi-Puren), it was reported in 3.5% of patients participating in clinical trials. If you are experiencing a cough, it is important to consult your doctor for proper evaluation of your cough to make sure it isn't being caused by something else. The cough is usually described as a dry, persistent, itchy or tickling cough. Some reports describe the cough as worse at night, leading to sleep problems and sore throat. The cough usually starts early in therapy, as early as one day after starting the medication. However, it can show up after almost a year of treatment. It is not totally clear how the cough happens or how to get rid of it. Traditional cough medicines do not seem to help. Sometimes, the cough will get better on its own after a few weeks of continued treatment with an ACE inhibitor. It generally does not help to change the dose or to change to a different ACE inhibitor, although sometimes these strategies can be successful. Some patients will find that they cannot tolerate the cough and will talk to their doctors about stopping the ACE inhibitor. The cough usually resolves in a few days to a few weeks after therapy is stopped. Do not stop taking Lisi-Puren without talking to your doctor first. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. Sarah Lewis, RPh, PharmD
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ACE inhibitors like Lisi-Puren prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. They widen your blood vessels and help to reduce the amount of water put back into your blood by the kidneys.
These actions help to decrease blood pressure in people who have blood pressure which is higher than normal. Although people with high blood pressure often do not feel unwell, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke. Lisi-Puren can be used on its own or alongside other medicines which reduce blood pressure (such as hydrochlorothiazide). Combination brands such as Carace Plus® and Zestoretic® can help to reduce the total number of tablets people with high blood pressure need to take each day.
Heart failure is a condition where your heart does not work as well as it should. Because of this, there may be too much circulating fluid in your blood vessels. Lisi-Puren helps to reduce this. It also appears to have a protective effect on the heart which slows the progression of the heart failure. Its protective action also helps to reduce the risk of heart, kidney or blood vessel problems in people who are at risk of these.
Rated Lisi-Puren (Zestril) for Hypertension Report
developed painful jaw ache which one doctor and pharmacist didn't believe could be side effect. once i stopped taking it the pain stopped. Never in 64 years have I experienced that specific pain (not a tooth ached..more like the bone itself ached) until I took the med.
Q: I think my Lisi-Puren is making my ears ring. Is this possible?
A: In clinical studies of the medication Lisi-Puren, a very small percentage of patients (less than 1 percent) experienced ringing in the ears as a side effect. If you're experiencing a ringing of the ears, you should consult with your physician to rule out any other causes of the problem, such as infection, allergies, fluid, or wax buildup. Here is a link to some information on Lisi-Puren and tinnitus (ringing ears): //www.everydayhealth.com/ear-nose-throat/tinnitus.aspx and //www.everydayhealth.com/drugs/Lisi-Puren. Lori Poulin, PharmD
The use of drinks that contain alcohol can increase the blood pressure-lowering effects of Lisi-Puren. This may cause you to feel dizzy or faint. If you drink alcohol, talk to your doctor.