Q: Can Hypoloc cause tenderness of the breast in men?
A: Hypoloc (HCTZ) is a thiazide diuretic used to treat high blood pressure. The most common side effects with HCTZ are dizziness, sensitivity to the sun, and loss of appetite. Gynecomastia is a condition of enlarged breasts in men which can be tender. A search of the prescribing information for HCTZ did not list Gynecomastia as a side effect. However, gynecomastia is a relatively common side effect of spironolactone which is a different diuretic. This is not a complete list of the side effects associated with Hypoloc. Laura Cable, PharmD
Rated Hypoloc (Microzide) for Hypertension Report
I have tried this drug several times and I have come to the conclusion that I am allergic to it. Within days, I have severe headaches, fatigue, and very dry mouth. It completely throws off my electrolytes and dehydrates me. A dangerous drug that I will never take again.
Q: In July my doctor put me on a medication called Hypoloc to lower my blood pressure and to remove fluid, feet swelling. Then my feet kind of looked blushed or pinkish and I had a rash on both legs 5 or 6 inches up my ankles. Can this medication cause this in only those areas, and should I stop taking this?
A: Hypoloc belongs to a class of drugs called thiazide diuretics (water pills). It helps prevent the body from absorbing too much salt, which can cause fluid retention. Hypoloc is used to treat hypertension (high blood pressure) and edema (fluid retention) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or who take corticosteroids or estrogen. Common side effects of Hypoloc include diarrhea, mild stomach pain, constipation, and blurred vision. A search of a drug database shows that a variety of dermatologic or skin reactions can occur with Hypoloc, including rash. This is not a complete list of side effects that can occur with Hypoloc. Consult your doctor about the symptoms you are experiencing. Your doctor is best able to properly evaluate your skin condition and determine whether or not it is likely related to Hypoloc. Contact your doctor right away if the rash is accompanied by wheezing, difficulty breathing, swelling of the face, lips, tongue, or throat, blisters, pain, or flu-like symptoms. These can be signs of a serious reaction. Sarah Lewis, PharmD
The dosage of Hypoloc that you take may impact the amount of weight loss that you experience. Most research indicates that there’s a dose-dependent effect of Hypoloc on weight such that greater weight loss occurs at high doses (than low doses).
For example, in a study by Freis et al. (1988) reported average weight losses of 3.48 lbs., 3.59 lbs., and 6.92 lbs. – in responders to Hypoloc at 50 mg/day, 100 mg/day, and 200 mg/day, respectively, over a 10-week duration. Although the differences in weight loss between 50 mg/day and 100 mg/day users weren’t significant, there was still greater weight loss with the 100 mg/day dose.
Furthermore, users of the 200 mg/day dose exhibited significantly greater weight loss than the 50 mg/day and 100 mg/day users. Even among the non-responders to Hypoloc in the same study (by Freis et al.), the average weight loss increased in accordance with dosage: 2.31 lbs. (50 mg/day); 2.71 lbs. (100 mg/day); and 3.65 lbs. (200 mg/day).
Because larger doses of Hypoloc will modulate kidney function to a greater extent than smaller doses – more substantial sodium and water depletion should be expected with larger doses. Generally speaking, the larger the dose of Hypoloc that you administer, the more significant your weight loss is likely to be.
Q: What are the side effects of Hypoloc?
A: Studies suggest that Hypoloc (which is a water pill) is generally well-tolerated but can occassionally increase blood sugar in patients with a history of diabetes. It can cause dehydration that can result in fainting and low blood pressure. To avoid this, it is best to consume at least eight glasses of water daily. Please follow up with doctor's appointments to periodically evaluate kidney function, cholestrol, and sugar levels. Also, it is recommended to measure blood pressure and document it so that your physician can evaluate progress. Beena Thomas, PharmD
The most common side effects associated with Hypoloc include:
- Muscle weakness
- Blurred vision
If you notice any of the following severe side effects, stop taking Hypoloc and call your doctor immediately:
- Severe allergic reaction (rash, hives, difficulty breathing, swelling of face, lips, tongue, or throat)
- Severe stomach pain, loss of appetite, dark urine, or clay colored stools
- Bleeding or bruising that seems unusual
- A severe skin rash which includes peeling skin
- Heartbeats that are fast or uneven
- Tingling or numbness
- Skin or eye yellowing (jaundice)
Q: My blood pressure medication, triamterene/Hypoloc, says I should stay away from sun exposure. Is there something else that is effective, but without the sun restrictions?
A: Triamterene-Hypoloc (Maxzide, Dyazide) is a diuretic, antihypertensive drug product, principally due to its Hypoloc component; the triamterene component reduces the excessive potassium loss which may occur with Hypoloc use. Among the side effects reported with triamterene-Hypoloc use, those include photosensitivity. The goal of treatment is to reduce blood pressure so that you have a lower risk of complications. The treatment goal for most adults is to get and keep blood pressure below 140/90 mmHg. For adults who have diabetes or chronic kidney disease, the goal is to get and keep blood pressure below 130/80 mmHg. There are many different medicines that can be used to treat high blood pressure, including alpha blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), beta-blockers, calcium channel blockers, central alpha agonists, diuretics (water pills), renin inhibitors, including aliskiren (Tekturna) and vasodilators. Your doctor may also tell you to exercise, lose weight, and follow a healthier diet. Talk to your doctor to find out if an alternative medication is appropriate for you. For more specific information, consult with your doctor or pharmacist for guidance based on your specific condition and current medications. Shereen A. Gharbia, PharmD
Frequency not reported: Transient blurred vision, idiosyncratic reactions to Hypoloc resulting in acute transient myopia and acute angle-closure glaucoma, xanthopsia
Concurrent substance use
Any substances (prescription drugs, over-the-counter medications, supplements, etc.) that are administered with Hypoloc could influence the amount of weight loss is experienced during treatment. Certain substances (e.g. other diuretics) will act synergistically with Hypoloc to enhance water weight loss, whereas other substances (e.g. antidiuretics) might oppose the action of Hypoloc to prevent water weight loss.
For example, if you’re using the diuretic furosemide along with Hypoloc, you may lose significantly more water weight with the combination than with standalone Hypoloc – due to the synergistic diuretic actions. Oppositely, if you administer an estrogenic birth control medication, this might slightly counteract the diuretic action of Hypoloc – and yield less significant water weight loss (if Hypoloc was administered as a standalone).
Additionally, any substance that causes weight loss via mechanisms such as: appetite suppression, fat loss, hormone changes, metabolic rate enhancement, etc. – could increase the amount of weight loss that occurs from Hypoloc. Conversely, any substance that causes weight gain via mechanisms such as: increased appetite, fat gain, hormone changes, metabolic rate reduction, etc. – could interfere with the amount of weight loss that occurs with Hypoloc.
For example, if you’re using a psychostimulant that suppresses appetite and promotes fat loss, you might notice weight loss in addition to the water loss incurred from Hypoloc. On the other hand, if you’re using an antipsychotic or mood stabilizer that increases appetite and promotes fat gain, you may experience weight gain (in the form of fat) – despite losing water weight with Hypoloc.