Hydrene capsules


  • Active Ingredient: Hydrochlorothiazide
  • 25 mg, 12.5 mg
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What is Hydrene?

The active ingredient of Hydrene brand is hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Hydrochloro­thiazide USP is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet for oral administration contains 25 mg or 50 mg Hydrochlorothiazide USP. In addition, each tablet contains the following inactive ingredients: dibasic calcium phosphate, lactose monohydrate, pregelatinized starch, FD&C yellow No.6 lake, corn starch, colloidal silicon dioxide, and magnesium stearate.

Used for

Hydrene is used to treat diseases such as: Diabetes Insipidus, Edema, High Blood Pressure, Nephrocalcinosis, Osteoporosis.

Side Effect

Possible side effects of Hydrene include: swelling of the face, fingers, legs, ankles, feet, or lower legs; redness or other discoloration of the skin; fever; sugar in the urine; difficulty having a bowel movement (stool); blue lips and fingernails.

How to Buy Hydrene tablets online?

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What is the dosage for Hydrene?

  • Hydrene may be taken with or without food.
  • The usual adult dose for hypertension is 12.5 to 50 mg once daily.
  • The usual adult dose for treating edema is 25-100 mg once daily or in divided doses.


Before taking Hydrene, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, kidney disease, liver disease, lupus, skin cancer.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Severe sweating, diarrhea, or vomiting can increase the risk for a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.

If you have diabetes, Hydrene may affect your blood sugar. Check your blood sugar regularly as directed by your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This drug may decrease your potassium levels. Ask your doctor about foods high in potassium (such as bananas, orange juice) or about using a salt substitute containing potassium. A potassium supplement may be prescribed by your doctor.

This medication may make you more sensitive to the sun. It may also increase your risk for skin cancer, especially if you take it for a long time. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned, have skin blisters/redness, or notice new or changed moles/skin lesions.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

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Rated Hydrene (Microzide) for Hypertension Report

I have many unwanted side effects, blurred vision, severe leg cramps, headaches every day, stomach pain, lightheaded, feel very overheated, flushed skin, constant urination, fast heartbeat, has lowered my BP, but these side effects are horrible

Variables that influence Hydrene weight loss

There are a variety of variables that may influence how much weight loss occurs on Hydrene. Variables that likely will impact the magnitude of Hydrene-induced weight loss include: (1) preexisting water retention; (2) Hydrene dose; (3) duration of treatment; (4) concomitant substance use; and (5) attributes of the specific Hydrene user. It is the combination of these variables that will account for differences in weight change among users.

What are the side effects of Hydrene?

Side effects of Hydrene include

More serious side effects include

Patients allergic to sulfa may also be allergic to Hydrene because of the similarity in the chemical structure of the medications.

Hydrene can aggravate kidney dysfunction and is used with caution in patients with kidney disease. Hydrene can lower blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to abnormalities in heart rhythm, especially in patients already taking digoxin (Lanoxin). During Hydrene treatment, supplementation with potassium is common to prevent low potassium levels.

Blood uric acid levels can increase during Hydrene treatment, and this elevation may cause an episode of acute gout in some individuals. Thiazide diuretics may increase blood sugar (glucose) levels and precipitate diabetes.

Q: I am taking 1/2 tablet of Hydrene, 25 mg. I feel that since starting on a diuretic that I'm not as alert as I used to be. Anything to this?

A: According to the manufacturer

Responses (1)

Lisinopril lowers blood pressure and has kidney protective properties which are good. Hydrene works in the kidneys to lower your blood pressure, your kidneys aren't that bad off to use something else. I say this because when your kidney function decreases to a certain point, Hydrene isn't able to get where it needs to be in order to work. Lipitor is for cholesterol and really doesn't have anything to do with the kidneys.

Thank you so much for your response to my question. I really understand now why I am taking these drugs for my kidneys!

What Is Hydrene?

Hydrene is a medication that is available as a generic and a brand name drug. The brand name is Microzide. Hydrene is part of a class of drugs known as diuretics, or "water pills." Diuretics cause you to make more urine, which helps your body eliminate extra salt and water. Hydrene is available as a tablet, capsule, or solution you take by the mouth.


Taking valsartan/Hydrene with lithium can increase the lithium levels in your body. This can cause lithium toxicity.


Thiazide diuretics may increase serum cholesterol and triglycerides, resulting in increased risk of cholesterol gallstone formation. Reports of bowel strictures associated with thiazide ingestion were reported in the 1960s although these patients were on a combination Hydrene-potassium product.

Frequency not reported: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia, acute cholecystitis

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