Furosal tablets

Furosal

  • Active Ingredient: Furosemide
  • 100 mg, 40 mg
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What is Furosal?

The active ingredient of Furosal brand is furosemide. Furosemide is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This allows the salt to instead be passed in your urine. C12H11ClN2O5S M.W. 330.74 Furosemide Tablets USP are available for oral administration containing 20 mg, 40 mg or 80 mg of Furosemide USP. The tablets meet Dissolution Test 1. Each tablet contains the following inactive ingredients: colloidal silicon dioxide, corn starch, lactose monohydrate, microcrystalline cellulose, pregelatinized starch, purified water, sodium lauryl sulfate, sodium starch glycolate and stearic acid. Furosemide Oral Solution USP is also available for oral administration containing either 10 mg per mL or 40 mg per 5 mL. The oral solution contains the following inactive ingredients: D and C Yellow No. 10, FD and C Yellow No. 6, flavors, potassium carbonate 1½ hydrate, propylene glycol, purified water and sorbitol solution. The 10 mg/mL solution is orange flavored and contains prosweet liquid and saccharin sodium. The 40 mg/5 mL solution is pineapple-peach flavored and contains sweet tone.

Used for

Furosal is used to treat diseases such as: Ascites, Edema, Heart Failure, High Blood Pressure, Hypercalcemia, Nonobstructive Oliguria, Oliguria, Pulmonary Edema, Renal Failure, Renal Transplant.

Side Effect

Possible side effects of Furosal include: confusion; difficulty breathing; sores, ulcers, or white spots on the lips or in the mouth; greatly decreased frequency of urination or amount of urine; hearing loss; cloudy urine.

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Which drugs or supplements interact with Furosal?

Administration of Furosal with aminoglycoside antibiotics (for example, gentamicin) or ethacrynic acid (Edecrin, another diuretic) may cause hearing damage.

Furosal competes with aspirin for elimination in the urine by the kidneys. Concomitant use of Furosal and aspirin may, therefore, lead to high blood levels of aspirin and aspirin toxicity.

Furosal also may reduce excretion of lithium (Eskalith, Lithobid) by the kidneys, causing increased blood levels of lithium and possible side effects from lithium.

Sucralfate (Carafate) reduces the action of Furosal by binding Furosal in the intestine and preventing its absorption into the body. Ingestion of Furosal and sucralfate should be separated by two hours.

When combined with other antihypertensive drugs there is an increased risk of low blood pressure or reduced kidney function.

Nonsteroidal anti-inflammatory drugs (for example., ibuprofen, indomethacin ) may interfere with the blood pressure reducing effect of Furosal.

This medication also interacts with certain drugs like:

Tell your doctor or other health care professional about any vitamins or supplements you are taking.

Q: What is the best over-the-counter water pill compared to Lasix?

A: There are a number of herbal water pills (or diuretics) found in over-the-counter weight loss products that contain various natural products. The over-the-counter water pills contain ingredients that come from caffeine. Although these products claim to decrease fluid retention and help with weight loss, scientific studies are limited and these claims have not been proven. In contrast, the diuretic effect of Lasix (Furosal) has been proven in numerous studies and is approved by the U.S. Food and Drug Administration for this use. Products that are sold as dietary or nutritional supplements in the United States do not undergo the same detailed testing that prescription drug products do to show that they are safe and effective. Supplement products can be marketed without any reliable scientific evidence of health benefits as long as the companies selling them do not claim the supplements can prevent, treat, or cure any specific disease. For more information, please consult your health care provider. Michelle McDermott, PharmD

Urgent advice: Call your doctor or go to A&E straight away if you take too much Furosal and you:

  • feel unwell
  • are over 65 (even if you feel well)
  • have kidney, liver or heart failure (even if you feel well)

Find your nearest A&E department. If you go to hospital, take the Furosal packet, or the leaflet inside it, plus any remaining medicine with you.

Like all medicines, Furosal can cause side effects although not everyone gets them.

Side effects often get better as your body gets used to the medicine.

What happens if I miss a dose?

Furosal is sometimes used only once, so you may not be on a dosing schedule. If you are using the medication regularly, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What is the most important information I should know about Furosal?

You should not use this medicine if you are unable to urinate.

Do not take more than your recommended dose. High doses of Furosal may cause irreversible hearing loss.

6. How to cope with s >

What to do about:

  • peeing more than normal - this will last for about 6 hours after taking Furosal. It's nothing to worry about, but if it's inconvenient for you, change the time you take Furosal to one that suits you better (provided it's no later than 4pm). If peeing a lot is still a problem for you, talk to your doctor or pharmacist.
  • feeling thirsty - it's important not to get dehydrated, but how much you drink will depend on why you're taking Furosal. Check with your doctor how much liquid you can drink while you're taking this medicine.
  • dry mouth - chew sugar-free gum or suck sugar-free sweets.
  • headaches - make sure you rest and drink fluids - ask your doctor how much you can drink while taking this medicine. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
  • feeling confused or dizzy - if Furosal makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you don't faint, then sit until you feel better. Do not drive or use tools or machines while you're feeling dizzy or shaky.
  • muscle cramps or weak muscles - if you get unusual muscle pain or weakness which isn't from exercise or hard work, talk to your doctor. You may need a blood test to check what might be causing it.
  • feeling or being sick (nausea or vomiting) - take Furosal with or just after a meal or snack. Take small, regular sips of water or squash so you don't get dehydrated (ask your doctor how much fulid you can drink). It may help if you stick to simple meals and don't eat rich or spicy food. This side effect usually wears off after a few days. Talk to your doctor about taking an anti-sickness medicine if it carries on for longer.

IMPORTANT WARNING:

Furosal is a strong diuretic ('water pill') and may cause dehydration and electrolyte imbalance. It is important that you take it exactly as told by your doctor. If you experience any of the following symptoms, call your doctor immediately: decreased urination; dry mouth; thirst; nausea; vomiting; weakness; drowsiness; confusion; muscle pain or cramps; or rapid or pounding heartbeats.

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Diuretics are also a common treatment for high blood pressure (hypertension). Furosal is prescribed for high blood pressure when it cannot be sufficiently controlled by other diuretics.

Furosal can be used on its own as a diuretic, or it can be prescribed as a combination tablet alongside other diuretics such as triamterene, amiloride or spironolactone. It is sometimes prescribed as a combination tablet with a mineral salt called potassium.

DESCRIPTION

LASIX® is a diuretic which is an anthranilic acid derivative. LASIX tablets for oral administration contain Furosal as the active ingredient and the following inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF. Chemically, it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. LASIX is available as white tablets for oral administration in dosage strengths of 20, 40 and 80 mg. Furosal is a white to off-white odorless crystalline powder. It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids.

The CAS Registry Number is 54-31-9.

The structural formula is as follows:


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