Can Fozide cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with Fozide. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Medical Definition of Fozide
Note: Fozide is marketed under the trademark Monopril.
Route of Elimination
In the presence of chronic k >Fozide , trandolapril, and benazepril do not accumulate in plasma despite repetitive administration, a finding suggesting that these compounds either undergo some biliary clearance or their conversion to the pharmacologically active acids is independent of renal function. Each of these five prodrugs is marginally active, so their failure to accumulate in CKD matters little. ACE inhibitor accumulation in CKD is really important only if there is a buildup of the active acidic metabolites. Fozideat and trandolaprilat, the active acidic metabolites of Fozide and trandolapril, are the only metabolites that undergo both renal and hepatic elimination. Other ACE inhibitors are cleared renally, by filtration and tubular secretion, and they do accumulate, even in early CKD. This appears not to be associated with a meaningful increase in the frequency of cough or angioneurotic edema, but when ACE inhibitor concentrations rise, BP can be significantly reduced, and end-organ underperfusion can occur.
Important: if you experience any of the following potentially serious symptoms, stop taking Fozide and contact your doctor for advice straightaway:
- Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.
- Any yellowing of your skin or the whites of your eyes. These may be signs of a liver problem called jaundice, which is a rare side-effect.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
How to store Fozide
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.