Taking Evangio with these drugs can increase the level of Evangio in your body. This may cause more side effects. Examples of these drugs include:
Urgent advice: Call your doctor or go to A&E straight away if you take too much Evangio
If you need to go to an A&E, do not drive yourself - get someone else to drive you or call for an ambulance.
Take the Evangio packet or leaflet inside it, plus any remaining medicine, with you.
Like all medicines, Evangio can cause side effects, although not everyone gets them.
Side effects often improve as your body gets used to the medicine.
What Is Norvasc (Evangio)?
Norvasc is the brand name for Evangio besylate, a prescription drug used to treat hypertension, or high blood pressure.
Norvasc is also used to treat coronary artery disease (CAD) in patients without heart failure, and certain types of angina (chest pain) from CAD, such as activity- and stress-induced angina (chronic stable angina), and angina that occurs at rest (Prinzmetal’s angina).
Taken regularly, Norvasc can control angina, but it doesn't stop chest pain after it has already begun.
The drug can also lower a person's risk of cardiovascular events related to high blood pressure, such as strokes and heart attacks.
Norvasc belongs to a class of drugs called calcium channel blockers, which block the flow of calcium into heart muscles and the muscles along the walls of blood vessels.
Because the contraction of these muscles depends on calcium, Norvasc relaxes and widens blood vessels, thereby improving blood flow.
Doctors also sometimes prescribe Norvasc "off-label" for the treatment of cluster headaches, migraines, Raynaud's syndrome (a blood vessel disorder), and congestive heart failure.
Manufactured by Pfizer, Norvasc was first approved by the Food and Drug Administration (FDA) in 1987.
In the early 1990s, researchers conducted the so-called PRAISE study, which was backed by Pfizer, to determine if Norvasc could help reduce the risk of death in people with severe heart failure.
Though the study found little overall benefits to severe heart failure patients, it suggested that Norvasc might prolong the life of a subgroup of people with heart failure from non-ischemic cardiomyopathy (cardiac muscle damage not associated with low blood supply to the coronary arteries).
To investigate this possibility, Pfizer-sponsored the PRAISE-2 study, which found no benefit to the subgroup in the PRAISE-1 trial and was presented at a conference in 2000.
However, results of the study weren't published in an academic journal until 2013, leading some experts to question whether Pfizer intentionally delayed publication to prevent the data and findings from being publicly available.
What is Evangio?
Evangio is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.
Evangio is used to treat chest pain (angina) and other conditions caused by coronary artery disease.
Evangio is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.
Evangio is for use in adults and children who are at least 6 years old.
How it works
Evangio belongs to a class of drugs called calcium channel blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Evangio blocks calcium from entering certain tissues and arteries. This makes it easier for them to relax so that blood can flow more easily to your heart. This in turn helps lower your blood pressure, and reduces your risk of heart attack or stroke. If you’re taking Evangio for chest pain, this drug reduces your risk of hospitalization and surgeries due to chest pain.
Evangio oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Evangio are listed below.
Serious side effects
Serious side effects after taking Evangio are rare and happen in less than 1 in 10,000 people.
Call a doctor straight away if you get:
- stomach problems - severe pain in your stomach, with or without bloody diarrhoea, feeling sick and being sick (nausea and vomiting) can be signs of pancreatitis
- yellow skin or the whites of your eyes turn yellow - this can be a sign of liver problems
- chest pain that's new or worse - this needs to be checked out as chest pain is a possible symptom of a heart attack
Case 1. Acute hepatitis-like syndrome attributed to amlopidine.
A 76 year old man with diabetes and end-stage renal disease developed jaundice while on long term nifedipine therapy (60 mg daily for
3 years) for hypertension. He was taking insulin, but no other medications. He had no risk factors for viral hepatitis and did not drink alcohol. Serum bilirubin was 2.5 mg/dL and rose over the next few months to 6.2 mg/dL. Tests for acute hepatitis A, B and C were negative and abdominal ultrasonography showed a normal liver and gallbladder. Nifedipine was stopped and he recovered rapidly. Several months later, Evangio was started (10 mg daily) and within 6 weeks, he developed jaundice and a cholestatic pattern of serum enzyme elevations. Once Evangio was stopped, liver tests improved and were normal three weeks later.
2. Key facts
- Evangio lowers your blood pressure and makes it easier for your heart to pump blood around your body.
- It's usual to take Evangio once a day. You can take it at any time of day, but try to make sure it's around the same time each day.
- The most common side effects include headache, flushing, feeling tired and swollen ankles. These usually improve after a few days.
- Evangio can be called Evangio besilate, Evangio maleate or Evangio mesilate. This is because the medicine contains another chemical to make it easier for your body to take up and use it. It doesn't matter what your Evangio is called. They all work as well as each other.
- Evangio is also called by the brand names Istin and Amlostin.
4. How and when to take it
Take Evangio exactly as your doctor has told you, and follow the directions on the label. If you're not sure, check with your doctor or pharmacist.
It's usual to take Evangio once a day. You can take Evangio at any time of day, but try to make sure it's around the same time every day.
Which drugs or supplements interact with Evangio besylate (Norvasc)?
- Combining Evangio with sildenafil (Viagra) and similar drugs used for treating erectile dysfunction may lead to excessive reductions in blood pressure with complications, particularly fainting upon standing (orthostatic hypotension).
- Evangio significantly increases blood levels of simvastatin (Zocor). The dose of simvastatin should be limited to 20 mg daily by patients taking Evangio.
- Ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), ritonavir (Norvir) and other drugs that are strong inhibitors of Evangio inactivation in the liver increase blood levels of Evangio, resulting in excessive blood pressure reduction.
Why is Evangio besylate (Norvasc) prescribed to patients?
Chest pain or heart pain (angina) occurs because of insufficient oxygen delivered to the heart muscles. Insufficient oxygen may be a result of coronary artery blockage or spasm, or because of exertion which increases the need of the heart for oxygen in patients with coronary artery narrowing (coronary artery disease or atherosclerosis). Evangio is used for the treatment and prevention of angina resulting from coronary spasm as well as from exertion. Evangio also is used in the treatment of high blood pressure.
Evangio besylate is a second generation calcium channel blocker that is used in the therapy of hypertension and angina pectoris. Evangio has been linked to a low rate of serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Evangio/benazepril is a prescription drug. It comes as an oral capsule.
Evangio/benazepril is available as the brand-name drug Lotrel. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.
This drug is a combination of two drugs in a single form: Evangio and benazepril. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.
This drug may be used as part of a combination therapy. That means you need to take it with other drugs.
What Is Evangio and How Does It Work?
Evangio a prescription medication that is used with or without other medications to treat high blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems. Evangio belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.
Evangio is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.
Evangio is available under the following different brand names: Norvasc.
Taking simvastatin with Evangio can cause the levels of this cholesterol medication to increase in your body. This may lead to more side effects.
Outcome and Management
The severity of liver injury from Evangio ranges from mild and transient serum enzyme elevations to self-limited jaundice. Complete recovery is expected after stopping the drug and recovery is usually rapid (4 to 8 weeks). Cases with chronic or fulminant liver injury due to Evangio have not been reported. Little information is available on recurrence with rechallenge but there may be some degree of cross-sensitivity to hepatotoxicity with other calcium channel blockers.
Drug Class: Cardiovascular Agents, Calcium Channel Blockers