Espironolactona tablets

Espironolactona

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Espironolactona?

The active ingredient of Espironolactona brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Espironolactona is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Espironolactona include: dimpling of the breast skin; indigestion; clay-colored stools; lump in the breast or under the arm; swelling of the breasts or breast soreness in both females and males.

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Pregnancy and Espironolactona

Espironolactona may pose risks to a developing fetus.

Some research suggests that Espironolactona has the potential to feminize male fetuses during early pregnancy and cause endocrine problems in late pregnancy by inhibiting the activity of male hormones (androgens).

In general, diuretics such as Espironolactona aren't recommended for pregnant women.

Unless the drug is absolutely necessary, it's not recommended for women who are breastfeeding because canrenone, a byproduct of Espironolactona, is excreted in breast milk.

Introduction

Espironolactona is an aldosterone receptor antagonist and potassium-sparing diuretic widely used in the therapy of edema, particularly in patients with cirrhosis in which hyperaldosteronism appears to play a major role. Espironolactona has been linked to rare cases of clinically apparent drug induced liver disease.

Espironolactona for Hair Loss and Hirsutism

Because of its anti-androgen activity, Espironolactona is also used off-label to treat female-pattern hair loss and hirsutism.

Women with certain endocrine disorders produce more androgens than normal, leading to hair loss on the top or front of the scalp, and increased hair on the face and other (generally hair-free) body areas.

Espironolactona helps by slowing down the production, and blocking the action, of androgens.

What is the dosage for Espironolactona?

  • Aldactone may be taken with or without food. The dosage range is 25-400 mg daily in single or divided doses.
  • The initial dose for treating edema in adults is 100 mg daily as a single dose or divided doses. The dose may be adjusted after 5 days based on response. The recommended dose range is 25 to 200 mg daily. The initial dose should be continued for at least 5 days before increasing the dose. If there is no adequate response after 5 days, a second diuretic may be added.
  • The dose for treating high blood pressure (hypertension) is 50 to 100 mg daily in single or divided doses.
  • The dose for treating hypokalemia is 25 to 100 mg daily.

Supplementation Options

Is Espironolactona the best treatment for your Polycystic Ovarian Syndrome symptoms pertaining to high levels of androgens (male hormones)? Before you decide whether to try this drug, you may want to know about herbal remedies for your symptoms. Supplementing with herbs may help you find relief, independently of or in addition to, pharmaceutical medications.

Below is a list of herbs commonly used to support healthy endocrine function.

Before taking Espironolactona,

  • tell your doctor and pharmacist if you are allergic to Espironolactona; any other medications; or any of the ingredients in Espironolactona tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking eplerenone (Inspra). Your doctor may tell you not to take Espironolactona if you are taking this medication.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin, kanamycin, neomycin (Neo-Rx, Neo-Fradin), streptomycin, and tobramycin (Tobi); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril, (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin II antagonists (angiotensin receptor blockers; ARBs) such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT, Tribenzor), telmisartan (Micardis, in Micardis HCT), and valsartan (Diovan, in Diovan HCT, Exforge); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDS) such as ibuprofen (Advil, Motrin), indomethacin (Indocin, Tivorbex), and naproxen (Aleve, Naprosyn); barbiturates such as phenobarbital; cholestyramine (Prevalite); cisplatin; digoxin (Lanoxin); diuretics ('water pills') including potassium-sparing diuretics such as amiloride (Midamor) and triamterene (Dyrenium, in Dyazide, in Maxzide); heparin or low-molecular-weight heparin enoxaparin (Lovenox); lithium (Lithobid); medications to treat high blood pressure; narcotic medications for pain; oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); potassium supplements; and trimethoprim (Primsol, in Bactrim).
  • tell your doctor if you have Addison's disease or other conditions that may cause high blood levels of potassium, or kidney disease. Your doctor may tell you not to take Espironolactona.
  • tell your doctor if you have liver disease.
  • tell your doctor if you are pregnant, or plan to become pregnant, or are breastfeeding. If you become pregnant while taking Espironolactona, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Espironolactona.
  • you should know that drinking alcohol with this medication may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. Talk to your doctor about drinking alcohol while you are taking Espironolactona.

Espironolactona is used to treat fluid retention (oedema) caused by liver disease, kidney problems or heart failure. Oedema occurs when fluid leaks out of your blood vessels, causing swelling in the tissues of your lungs, feet or ankles. This makes you feel breathless or your legs feel puffy. Espironolactona prevents a build-up of fluid in your body by increasing the amount of urine your kidneys produce. It is also used to treat some other conditions which cause fluid retention, such as a disorder called primary hyperaldosteronism.

Case 1. Espironolactona induced liver injury.

A 53 year old woman with primary hyperaldosteronism due to an adrenal adenoma was found to have serum enzyme elevations (ALT 430 U/L, AST 130 U/L, Alk P 225 U/L) without symptoms 1 month after starting Espironolactona (100 mg three times daily). Espironolactona was stopped and serum enzymes fell into the normal range within the next two months. One year later, Espironolactona was restarted (100 mg twice daily) and serum enzymes were again found to be abnormal one month later. She was not taking other medications and tests for hepatitis B and for autoantibodies were negative. There was no rash, fever or eosinophilia. A liver biopsy showed mild spotty hepatitis. Upon withdrawal of Espironolactona, serum enzymes fell to normal within 6 weeks.

Rated Espironolactona (Aldactone) for Acne Report

I’m not one to write reviews but I thought I’d give my two cents on this medication. Throughout my teenage years, I had clear skin. Once I hit 21, my skin grew a hatred for me. I had painful cystic acne all on my chin and jaw line. After trying literally everything except accutane, I decided to try this. I was skeptical at first but I figured I had nothing to lose. I started off with 25mg a day and saw no improvement so I switched to 50mg a day. That was 3 months ago. I now have the same clear skin I had in my teenage years, I just have some scarring left from old acne spots but those are now fading. You NEED to take this with food because it will make you very nauseous if you don’t. I have not gained or lost any weight. I do get headaches sometimes if I don’t drink enough water because this is a diuretic. With that said, you will pee A LOT. So remember to keep drinking fluids. My breasts have gotten slightly larger but that’s a huge perk for me. Overall, this medicine is well worth the side effects I’ve experienced and it saved my skin.

How it works

This drug belongs to a class of drugs called aldosterone antagonists (blockers), or potassium-sparing diuretics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by blocking aldosterone activity. Aldosterone is a chemical made by the body that can cause water retention. This makes certain heart, kidney, and liver conditions worse. By blocking aldosterone, your body won’t retain fluid. This process also stops potassium from being excreted by your body.

This drug may lower your blood pressure by blocking aldosterone’s effect on your blood vessels.

Espironolactona oral tablet may cause drowsiness. You shouldn’t drive, use machinery, or do similar tasks that require alertness until you know how this drug affects you.

This drug can also cause other side effects.


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