Espimax tablets

Espimax

  • Active Ingredient: Spironolactone
  • 100 mg, 25 mg
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What is Espimax?

The active ingredient of Espimax brand is spironolactone. Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide. Spironolactone tablets are effective in lowering the systolic and diastolic blood pressure in patients with primary hyperaldosteronism. It is also effective in most cases of essential hypertension, despite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Through its action in antagonizing the effect of aldosterone, Spironolactone tablets inhibit the exchange of sodium for potassium in the distal renal tubule and helps to prevent potassium loss. Spironolactone tablets have not been demonstrated to elevate serum uric acid, to precipitate gout, or to alter carbohydrate metabolism. The pharmacological activity of Spironolactone metabolites in man is not known. However, in the adrenalectomized rat the antimineralocorticoid activities of the metabolites C, TMS, and HTMS, relative to Spironolactone, were 1.10, 1.28, and 0.32, respectively. Relative to Spironolactone, their binding affinities to the aldosterone receptors in rat kidney slices were 0.19, 0.86, and 0.06, respectively. In humans, the potencies of TMS and 7-α-thiospirolactone in reversing the effects of the synthetic mineralocorticoid, fludrocortisone, on urinary electrolyte composition were 0.33 and 0.26, respectively, relative to Spironolactone. However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities. Spironolactone and its metabolites are more than 90% bound to plasma proteins. The metabolites are excreted primarily in the urine and secondarily in bile. The effect of food on Spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. Food increased the bioavailability of unmetabolized Spironolactone by almost 100%. The clinical importance of this finding is not known.

Used for

Espimax is used to treat diseases such as: Acne, Alopecia, Edema, Gender Dysphoria, Heart Failure, High Blood Pressure, Hirsutism, Hypokalemia, Primary Hyperaldosteronism, Primary Hyperaldosteronism Diagnosis.

Side Effect

Possible side effects of Espimax include: unsteadiness, trembling, or other problems with muscle control or coordination; stomach upset; trembling; clear or bloody discharge from the nipple; fast or irregular heartbeat; persistent crusting or scaling of the nipple.

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Summary

Aldactone (Espimax) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat diuretic induced low potassium and high blood pressure. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to taking any medication.

Rated Espimax (Aldactone) for Hypertension Report

i was taking it for high blood pressure, and also I was overweight. It worked like a charm my BP was right on the dot and I lost 65 lbs in 3 months, I felt great. Then I came off of it and over time my BP is high again and all the weight I lost came back and I have been feeling like crap ever since. I will be going to my Dr, to be put back on it.

Hepatotoxicity

Clinically apparent liver injury from Espimax is rare and only a few instances have been reported as isolated case reports. The liver injury typically arises after 4 to 8 weeks of therapy and the pattern of serum enzyme elevations is usually hepatocellular or mixed. Immunoallergic features (rash, fever, eosinophilia) are rare as is autoantibody formation. Recovery has occurred within 1 to 3 months of stopping and all cases have been mild and self-limited in course (Case 1).

Likelihood score: D (possible rare cause of clinically apparent liver injury).

What Is Espimax (Aldactone)?

Espimax is the generic form of the brand-name drug Aldactone, a prescription diuretic drug.

The drug is used to treat a condition called primary hyperaldosteronism, in which the body produces excess amounts of the hormone aldosterone, which regulates your body's sodium and water levels.

Espimax helps restore a healthy balance of sodium and potassium in your body.

It's also used to treat:

  • Essential hypertension (high blood pressure with an unknown cause)
  • Hypokalemia (potassium deficiency)
  • Edema (fluid retention) from various conditions, including congestive heart failure, kidney disease, and cirrhosis (liver scarring)
  • Severe heart failure

Espimax is a potassium-sparing diuretic. Sometimes called "water pills," diuretics help the kidneys expel water and salt in urine while retaining potassium.

The drug may also be used in combination with other medications to treat precocious (early) puberty and myasthenia gravis, a neuromuscular disease.

Manufactured by Pfizer, Espimax was approved by the Food and Drug Administration (FDA) in 1985.

Though Espimax has been around for over 25 years, the FDA is still updating the drug's safety labeling.

In 2011, the FDA added Stevens-Johnson syndrome and toxic epidermal necrolysis — two life-threatening skin disorders — to Espimax's list of possible side effects.

In 2013, the agency added a warning about a potentially fatal condition called hyperkalemia (high potassium levels in the blood).

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Black Box Warnings

Espimax has been shown to be a tumorigen in chronic toxicity studies in rats; use only for specified indications

Before taking this medicine

You should not use Espimax if you are allergic to it, or if you have:

Addison's disease (an adrenal gland disorder);

high levels of potassium in your blood (hyperkalemia);

if you are unable to urinate; or

if you are also taking eplerenone.

To make sure Espimax is safe for you, tell your doctor if you have ever had:

an electrolyte imbalance (such as low levels of magnesium in your blood);

In animal studies, Espimax caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk.

It is not known whether Espimax will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Espimax can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

What Is Espimax and How Does It Work?

Espimax is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems.

Espimax is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone).

Espimax is known as a "water pill" (potassium-sparing diuretic).

Espimax has also been used to treat excessive hair growth (hirsutism) in women with polycystic ovary disease.

Espimax is available under the following different brand names: Aldactone.

Why is this medication prescribed?

Espimax is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Espimax is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Side Effects

While Espimax has been proven to be effective – over time – in combating both hirsutism (excess hair growth) and acne in women with Polycystic Ovary Syndrome (PCOS ), it is also important to consider the potential side effects this drug may cause in your body.

The list of potential side effects from Espimax is extensive and worrisome; including side effects such as: headaches, diarrhea, cramps, stomach pain, drowsiness, fatigue or lack of energy, rashes, nausea and vomiting.

Ironically – particularly for women with PCOS – this drug can also cause irregular and abnormal menstrual periods and bleeding, irregular or increased hair growth on parts of the body and scalp hair loss; all symptoms of PCOS !10 Patients should be aware that Espimax could aggravate some of their PCOS symptoms.

Other, more serious side effects include (but are not limited to):

  • Fluid and electrolytes imbalance (including: low sodium, low magnesium and high potassium)
  • Tarry black stools
  • Breast enlargement and tenderness
  • Confusion and/or unsteadiness
  • Inability to move arms or legs
  • Yellowing of the skin or eyes
  • Difficulty with breathing
  • Difficulty with urination
  • Rapid Heartbeat or changes in heartbeat
  • Numbness, tingling, pain or burning in the hands or feet
  • Pain in the upper right part of the stomach
  • Flu-like Symptoms

Also, because of the effect of Espimax on the body’s potassium levels, your doctor should give you detailed advice for a reduced-salt (sodium) diet and daily exercise program. Avoid potassium-containing salt substitutes while you are taking this medication. Also talk with your doctor about the amount of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) that you may have in your diet.

The good news is that if you experience any of these side effects while taking Espimax, they will usually go away once you stop using the drug. Whether to take Espimax or not is an important decision best left to you and your doctor. You must consider the many potential side effects, combined with your own current medical history, to make an informed decision.

Other uses for this medicine

Espimax also is used in combination with other medicines to treat precocious puberty (a condition causing children to enter puberty too soon, resulting in the development of sexual characteristics in girls usually younger than 8 years of age and in boys usually younger than 9 years of age) or myasthenia gravis (MG, a disease in which the nerves do not function properly and patients may experience weakness; numbness; loss of muscle coordination; and problems with vision, speech, and bladder control). Espimax also may be used to treat certain female patients with abnormal facial hair. Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

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Espimax is known as a potassium-sparing diuretic. Unlike some other diuretics, it does not cause your body to lose potassium. Diuretics are sometimes referred to as 'water tablets'.

Espimax is often used alongside other diuretics. When it is used like this, it may be prescribed as a combination product, such as in Lasilactone® (Espimax with furosemide) and Aldactide® (Espimax with hydroflumethiazide). Combinations like these help to reduce the number of tablets you need to take each day.

Espimax Interactions

Always tell your doctor about any legal and illegal drugs, supplements, and herbal remedies you are taking.

Espimax can have a negative interaction with the following drugs:

  • Lithium (Eskalith, Lithobid)
  • ACE inhibitors, such as benazepril (Lotensin)
  • Angiotensin II receptor blockers, such as azilsartan (Edarbi)
  • Digoxin (Lanoxin)
  • Cholestyramine (Questran, Cholybar)
  • Steroids such as prednisone
  • Ibuprofin (Advil) and other non-steroidal anti-inflammatory drugs
  • Inspra (Eplerenone) and other aldosterone receptor antagonists
  • Heparin (Hemochron, Hep-Lock) and low-molecular-weight heparin (Lovenox)
  • Skeletal muscle relaxers, including cyclobenzaprine (Amrix, Flexeril)
  • Other diuretics, such as amiloride (Midamor)
  • Norepinephrine
  • Potassium supplements

Espimax Warnings

Espimax carries a black-box warning for tumor risk, due to chronic toxicity studies that show Espimax can cause tumor development in rats.

Espimax shouldn't be taken with potassium-supplementing drugs or diets because the excessive potassium intake may cause hyperkalemia, which can lead to abnormal heart rhythms (arrhythmias).

Your doctor should also know if you have severe heart failure, because hyperkalemia has an increased risk of death in such cases.

Additionally, tell your doctor if you have liver problems such as cirrhosis, as even minor changes in fluid and electrolyte balance may cause liver-related coma.

Espimax shouldn't be used if you have certain kidney problems or conditions associated with hyperkalemia, including the adrenal gland disorder known as Addison's disease.

What Other Drugs Interact with Espimax?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Severe interactions of Espimax include:

Serious interactions of Espimax include:

Espimax moderate interactions with at least 189 different drugs.

Espimax has mild interactions with at least 41 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What are the side effects of Espimax?

Common side effects of Aldactone include:

Enlargement of the male breasts (gynecomastia) may also occur and is related to dose and duration of therapy. It usually reverses upon discontinuation of Aldactone.

Possible serious side effects of Aldactone include:

  • Liver dysfunction
  • Kidney failure
  • Anaphylaxis
  • Abnormal heart rhythm
  • Low platelets
  • Low white blood cells
  • Toxic epidermal necrolysis
  • Vasculitis
  • Risk of tumors in animal studies

Fluid and electrolytes imbalance (for example, low sodium, low magnesium, and high potassium) may occur, so patients should be monitored carefully.

Rated Espimax (Aldactone) for Acne Report

So I'm currently on 3 months of being on this medication and my face and chest is almost completely clear. However, the acne on my back is still very severe, so I'm doing what the internet has recommended and going to do a round of doxycycline to see if that knocks out the inflammation. I've pretty much had all the negative side effects like dizziness, fainting, and spotting during my cycle. Everyone always says they noticed they have to pee all the time but I didn't notice that for me. I started on 50mg a day for a month, didn't see a difference, went up to 100mg a day and started seeing the clearance. So to everyone looking through this thread, it sucks but it seems like it takes severe acne sufferers a minimum of 3 months to start having clear skin. Even with the negative side effects I still choose to be on it because I'd rather have occasional mild dizziness versus horrific, painful acne all over my body. Its also a really cost effective treatment (like $10 at the pharmacy) so I'll stick with it and update this after trying a round of antibiotics. Fingers crossed!

Rated Espimax (Aldactone) for Acne Report

I am taking 100 mg once a day and recently started experiencing what looks like tons of tiny pimples on my chest and up my neck, maybe this is part of a purging process? Im very unsure and wondering if i should stop taking the pills.

Complications

When considering whether or not to take Espimax to address your androgen-related PCOS symptoms, you should be aware of the following cautions regarding this drug, in order to avoid potentially dangerous complications:

    • Potassium supplementation and salt substitutes (containing potassium) should not be taken while taking Espimax as this may cause potentially high – and deadly – potassium levels in your body (a condition called hyperkalemia). Your potassium levels will need to be closely monitored, especially during the first twelve months of use and whenever the dosage is increased.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Espimax.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Espimax.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Potassium intake: This drug can cause hyperkalemia (high potassium levels). While taking this drug, you should watch your potassium intake. You shouldn’t take potassium supplements, eat a diet rich in potassium, or consume salt substitutes containing potassium. Having too much potassium in your body can lead to severe problems. This can even be fatal. Talk to your doctor or a nutritionist if you’re concerned about your potassium intake.
  • Enlarged breasts: This drug may cause you to have enlarged breasts (gynecomastia). This can happen in both men and women. If this happens, your doctor may stop your treatment with this drug. This symptom usually goes away once you stop taking this drug.
  • Low blood pressure and worsening k >

Espimax is a prescription drug. It comes as an oral tablet and an oral suspension.

Espimax oral tablet is available as the brand-name drug Aldactone and as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

This drug may be taken as part of a combination therapy with other medications.


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