Esidrex tablets


  • Active Ingredient: Hydrochlorothiazide
  • 25 mg, 12.5 mg
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What is Esidrex?

The active ingredient of Esidrex brand is hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Hydrochloro­thiazide USP is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet for oral administration contains 25 mg or 50 mg Hydrochlorothiazide USP. In addition, each tablet contains the following inactive ingredients: dibasic calcium phosphate, lactose monohydrate, pregelatinized starch, FD&C yellow No.6 lake, corn starch, colloidal silicon dioxide, and magnesium stearate.

Used for

Esidrex is used to treat diseases such as: Diabetes Insipidus, Edema, High Blood Pressure, Nephrocalcinosis, Osteoporosis.

Side Effect

Possible side effects of Esidrex include: black, tarry stools; tightness in the chest; blistering, peeling, or loosening of the skin; general feeling of tiredness or weakness; nausea or vomiting; constipation.

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Rated Esidrex (Microzide) for Edema Report

Made my face and scalp itch. Made my scalp burn and hair fell out in patches.

Sodium & water depletion

Esidrex and other thiazide diuretics cause weight loss principally by inhibiting the sodium-chloride (Na+/Cl-) symporter, a cotransporter in the kidneys which is responsible for facilitating reabsorption of sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. Inhibition of the sodium-chloride symporter by Esidrex prevents sodium reabsorption, induces natriuresis (sodium excretion), increases urinary flow, and promotes water loss.

As a result, bodily tissues end up losing a significant amount of water. After the sodium and water loss occurs, anyone who steps on a scale and weighs themselves will notice that they’ve lost weight. Some sources suggest that with diuretics like Esidrex, some individuals can lose between 10 lbs. and 20 lbs. of water weight in less than 1 week.

Among persons with preexisting edema as a result of a medical condition or medication side effect – the water weight loss that results from Esidrex use may be substantial. While Esidrex-mediated water depletion may yield rapid and substantial weight loss – it is important to remember that this is not body fat loss; bodily tissues are simply storing less water than before treatment.

Q: Does Esidrex affect sexual performance in men?

A: Esidrex belongs to a class of drugs called thiazide diuretics (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. It treats edema (fluid retention) in people with congestive heart failure, liver cirrhosis, or kidney disorders, or edema caused by taking steroids or estrogen. Esidrex is also used to treat hypertension (high blood pressure). Common side effects of Esidrex include diarrhea, mild stomach pain, constipation, and blurred vision. A search of the prescribing information for Esidrex did not specifically list impotence or erectile dysfunction as a side effect. However, the medical literature does contain reports of impotence in men taking Esidrex, especially when it is used in combination with other medications to treat hypertension. So, there may be some association between this medication and sexual problems in men. Consult your doctor about your symptoms and for specific recommendations. This is not a complete list of the side effects associated with Esidrex. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting or by calling 1-800-FDA-1088. Sarah Lewis, RPh

Q: When is it best to take Esidrex, in the morning or at night, for best results?

A: Esidrex (Microzide) is a thiazide diuretic (water pill) used to treat fluid retention and high blood pressure. The most common side effects of Esidrex are low blood pressure, low potassium levels and sensitivity to the sun. Esidrex will increase urination so it is recommended to take it in the morning to decrease the amount of time spent getting up at night to urinate. However, you should always check with your doctor or local pharmacist for more specific instructions. Esidrex may be taken with or without food. It is recommended to always wear sunscreen with at least SPF 15 to prevent sun damage to the skin. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD

Rated Esidrex (Microzide) for Hypertension Report

This is the third medicate that I am taking for high blood pressure. The first give me a couch and the second caused swelling. This one I have very bad cramps, legs, hands, arms, back, top of feet, toes you name and it will camp. This can last for a hour or two. Which is why I am up so late tonight. Will stop and not take anymore until I talk to Dr. Thanks for sharing.

Warnings for people with certain health conditions

For people with kidney problems: Use caution when taking Esidrex if you have poor kidney function. This drug is cleared from your body by your kidneys. If your kidneys don’t work as well, this drug may build up in your body and cause more side effects. If your kidney function gets worse, your doctor might stop your treatment with this medication.

For people with kidneys that don’t make enough urine: You can’t take Esidrex if your kidneys can’t make enough urine. This drug can cause electrolyte and fluid loss, which may make you produce even less urine.

For people with poor liver function: Use this drug with caution if you have poor liver function or progressive liver disease. Esidrex can cause electrolyte and fluid imbalance. This can make your liver function worse.

For people with lupus: This drug can cause your lupus to flare up.

Reduce Edema

Doctors also prescribe Esidrex to reduce excessive fluid accumulation in the body (edema) that has been caused by heart failure, liver damage, kidney failure, nephrotic syndrome (a kidney disorder that causes the body to excrete too much protein in your urine) and certain medications, especially corticosteroids.

While Esidrex may be used to treat edema in cirrhosis of the liver, there are more effective diuretics that are used in that case.

More common side effects

The more common side effects that can occur with Esidrex include:

  • blood pressure that’s lower than normal (especially when standing up after sitting or lying down)
  • dizziness
  • headache
  • weakness
  • erectile dysfunction (trouble getting or keeping an erection)
  • tingling in your hands, legs, and feet

These effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

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