Blood pressure drugs
Taking Diur with other blood pressure medications can make your blood pressure drop too low. Examples of these drugs include:
- angiotensin-converting enzyme (ACE) inhibitors, such as:
In general, lithium shouldn’t be taken with Diur. That’s because Diur slows the clearance of lithium from your body. This increases your risk of high levels of lithium in your body, which can cause dangerous side effects.
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Microzide (Diur) is a diuretic (water pill) prescribed for lowering blood pressure (hypertension) and accumulation of fluid (edema). Microzide is available as a generic drug. Common side effects of Microzide include:
Tell your doctor if you have serious side effects of Microzide including:
Microzide dose ranges from 12.5 to 100 mg/day depending on the condition that is being treated. Microzide may interact with other medicines that make you lightheaded (such as cold medicines, pain medications, muscle relaxers, and medicines for seizures, depression or anxiety), lithium, digoxin, cholestyramine, colestipol, steroids, other blood pressure medication, nonsteroidal anti-inflammatory drugs (NSAIDs) (such as aspirin, ibuprofen, naproxen, and others), or insulin or oral diabetes medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Microzide. Microzide is not expected to be harmful to a fetus. Microzide can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.
Our Microzide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Diur should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in a tight, light-resistant container.
Q: Does Diur affect sexual performance in men?
A: Diur belongs to a class of drugs called thiazide diuretics (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. It treats edema (fluid retention) in people with congestive heart failure, liver cirrhosis, or kidney disorders, or edema caused by taking steroids or estrogen. Diur is also used to treat hypertension (high blood pressure). Common side effects of Diur include diarrhea, mild stomach pain, constipation, and blurred vision. A search of the prescribing information for Diur did not specifically list impotence or erectile dysfunction as a side effect. However, the medical literature does contain reports of impotence in men taking Diur, especially when it is used in combination with other medications to treat hypertension. So, there may be some association between this medication and sexual problems in men. Consult your doctor about your symptoms and for specific recommendations. This is not a complete list of the side effects associated with Diur. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your healthcare providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088. Sarah Lewis, RPh
Rebound effect (Regained water weight after stopping)
Diur and other diuretics help decrease water weight and bloating, however, this effect is temporary – the medication must be administered regularly to maintain the water weight loss. When Diur treatment is discontinued, kidney function will normalize such that sodium and water are reabsorbed at standard quantities.
Normalization of sodium and water reabsorption means that all of water weight that was lost throughout treatment will be regained. Furthermore, some have suggested that long-term diuretic usage might trigger excessive rebound weight gain in the aftermath of diuretic discontinuation due to transient renal adaptations induced by treatment.
In other words, it is thought that sodium reabsorption and water retention may substantially increase (above homeostatic baseline) for an unspecified duration after Diur discontinuation – as a “rebound effect.” This substantial increase might cause a former Diur user to temporarily weigh more (in terms of water) than they did before treatment.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symbarbiturates ptoms can include the following:
- Low blood pressure. Symptoms can include:
- lightheadedness or dizziness, especially if you stand up after sitting or lying down
- changes in the amount you urinate
- swelling in your feet or ankles
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Valsartan/Diur oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with valsartan/Diur are listed below.
Taking valsartan/Diur with this drug can increase your risk of gout.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Why is this medication prescribed?
Diur is used alone or in combination with other medications to treat high blood pressure. Diur is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Diur is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Warnings for certain groups
For pregnant women: Diur is a category B pregnancy drug. That means two things:
- Research in animals hasn’t shown a risk to the fetus when the mother takes the drug.
- There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.
Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies don’t always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.
For women who are breastfeeding: Diur may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.
Diur is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug or don’t take it at all: Your swelling and high blood pressure might get worse. High blood pressure raises your risk of heart attack or stroke.
If you stop taking the drug suddenly, your swelling can increase and your blood pressure might increase rapidly. High blood pressure raises your risk of heart attack or stroke.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: If you take too much Diur, your blood pressure might drop too low. You might feel faint or dizzy.
If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause dangerous side effects.
How to tell if the drug is working: Your blood pressure should be lower or the swelling in your legs and feet should get better.
Your doctor will monitor your blood pressure at your checkups. You can also check your blood pressure at home. Keep a log with the date, time of day, and your blood pressure readings. Bring this log with you to your doctor appointments.
Keep these considerations in mind if your doctor prescribes Diur for you.
Vision problems warning
Diur can cause blurred vision and glaucoma. Symptoms include eye pain and trouble seeing. These problems often occur within hours to weeks after starting this medication.
Tell your doctor if you have any vision problems while taking this drug. If you have blurred vision, it may return to normal after you stop taking this medication. However, if left untreated, certain vision problems can lead to permanent vision loss.
Forms and strengths
- Form: oral tablet
- Strengths: 12.5 mg, 25 mg, and 50 mg
Which drugs or supplements interact with Diur?
- Diur reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of Diur. Blood sugar levels can be elevated by Diur, necessitating adjustment in the doses of medications that are used for treating diabetes.
- Combining Diur with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium (hypokalemia) can increase the toxicity of digoxin (Lanoxin).
- Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to Diur and reduce its absorption from the gastrointestinal tract by 43% to 85%.
Q: I am taking 1/2 tablet of Diur, 25 mg. I feel that since starting on a diuretic that I'm not as alert as I used to be. Anything to this?
A: According to the manufacturer
What is Hydrochlorothiaz >
Diur is the generic form of the brand-name drug Microzide.
It's a prescription diuretic ("water pill") that's used to treat high blood pressure and other conditions.
Diur is designed to help eliminate the excessive fluid accumulation and swelling that’s often caused by congestive heart failure, cirrhosis of the liver, chronic kidney failure, corticosteroid medications and nephrotic syndrome.
Diur is the second most commonly prescribed antihypertensive in the United States. Despite its popularity, researchers do not have a clear grasp as to how it works to lower blood pressure.
Most blood pressure lowering medications, including Diur, are prescribed together with other hypertensive products, along with dietary restrictions, exercise, and, in some cases, weight loss.
Diur may also be prescribed to treat calcium-containing kidney stones because it decreases the amount of calcium excreted by the kidneys in the urine, thus reducing the amount of calcium available to form stones.
Although Diur is approved to treat edema in cirrhosis of the liver, it’s rarely used for that purpose because other diuretics are considered more effective.
The Food and Drug Administration (FDA) approved Diur in 1959. It's manufactured by several companies, including Mylan, Vintage Pharmaceuticals, and Watson Labs.
In addition to Microzide, Diur is available as: